CAS No.: 749269-83-8
Itanapraced Catalog No. CSN16335
Synonyms: CHF5074;CSP-1103;CS 1103
CHF5074 is a γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00954252 Alzheimer's Disease Phase 1 Completed - United States, New Jersey ... more >> Iberica Clinical Research Center Eatontown, NJ 07724, New Jersey, United States, 07724 Collapse << NCT01421056 Alzheimer's Disease Phase 2 Completed - United States, New Jersey ... more >> Memory Enhancement Center of America, Inc. Eatontown, New Jersey, United States, 07724 Memory Center of New Jersey, Inc. Monroe Twp, New Jersey, United States, 08831 Memory Enhancement Center of NJ, Inc. Toms River, New Jersey, United States, 08755 United States, Texas Senior Adults Specialty Research Austin, Texas, United States, 78757 Italy Clinica Santa Maria, Div Neurologia Castellanza, Italy Osp. Niguarda Ca'Granda, Dip. Di Neuroscienze Milano, Italy Collapse << NCT01723670 Alzheimer's Disease Phase 2 Withdrawn March 2016 - - 更多
- 参考文献
- [1] Mango D, Barbato G, et al. Electrophysiological and metabolic effects of CHF5074 in the hippocampus: protection against in vitro ischemia. Pharmacol Res. 2014 Mar;81:83-90.
- [2] Imbimbo BP, Del Giudice E, et al. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl] -4-yl)-cyclopropanecarboxylic acid(CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity. J Pharmacol Exp Ther. 2007 Dec;323(3):822-30.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 749269-83-8 | 储存条件 |
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| 分子式 | C16H11Cl2FO2 | 运输 | 蓝冰 | |
| 分子量 | 325.16 | 别名 | CHF5074;CSP-1103;CS 1103 |
