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CAS No.: 1408064-71-0

JNK-IN-7 Catalog No. CSN17806

Synonyms: JNK inhibitor;JNK Inhibitor VII;c-Jun N-terminal Kinase Inhibitor VII

JNK-IN-7 is a potent inhibitor for JNK all isoforms with IC50 values of 1.5, 2 and 0.7 nM for JNK1, JNK2 and JNK3, respectively.

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400-920-2911

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 JNK3

IC50:0.75 JNK1

IC50:1.54 JNK2

IC50:1.99
描述JNKs (c-jun NH2-terminal kinases) are serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the JNK signaling pathway. There are three distinct alternatively spliced genes (Jnk1, Jnk2, and Jnk3) that produce approximately ten different proteins. The predominant isoforms JNK1 and JNK2 are ubiquitously expressed, but JNK3 is expressed primarily in the nervous system. JNK-IN-7 is a JNK inhibitor with IC₅₀ values of 1.54 nM, 1.99 nM, 0.75 nM to JNK1, JNK2, JNK3, respectively^[3]. It also inhibits phosphorylation of c-Jun, which is a direct substrate of JNK kinase in Hela and A375 cells, with EC₅₀s of 130nM and 244nM, respectively^[3]. At the concentration of 1μM, 48h incubation of JNK-IN-7 could rescue the down-regulation of DMT-1 expression resulted by TNF^[4]. At the concentrations of 1mM or 10mM, JNK-IN-7 inhibited the IL-1-stimulated activation of Pellino 1 in IL-1R cells^[5].
作用机制JNK-IN-7 is a covalent inhibitor of JNKs^[3].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0261 mL
- 10.1305 mL
- 20.2610 mL
- 5 mM
- 0.4052 mL
- 2.0261 mL
- 4.0522 mL
- 10 mM
- 0.2026 mL
- 1.0130 mL
- 2.0261 mL

技术信息

CAS号

1408064-71-0

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C28H27N7O2

运输

蓝冰

分子量

493.56

别名

JNK inhibitor;JNK Inhibitor VII;c-Jun N-terminal Kinase Inhibitor VII

溶解度

DMSO	30.0 mg/mL (60.8 mM) warming
Water	Insoluble

动物实验配方

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靶点	Description	IC50
JNK3		IC50:0.75
JNK1		IC50:1.54
JNK2		IC50:1.99

JNK-IN-7 Catalog No. CSN17806

靶点选择性

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