|4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯|CsnPharm

CAS No.: 1210004-12-8

JZL 195 Catalog No. CSN17567

Synonyms: N/A

JZL195 functions as a dual inhibitor of FAAH and MAGL with IC50 of 13 nM and 19 nM respectively in brain of mouse.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 values of 2nM and 4nM, respectively. It exhibited broad activity in the tetrad test for CB1 agonism, causing analgesia, hypomotilty, and catalepsy. Male C57BL/6 mice administered JZL195 at doses ranging in 3–20mg/kg, i.p., for 4h showed dose-dependent reductions in brain FAAH, MAGL, and ABHD6 activities as judged by gel-based ABPP that correlated with near-complete inhibition of both AEA and 2-AG hydrolysis^[6]. JZL195 reduced inflammation induced allodynia, mechanical allodynia and thermal hyperalgesia, as well as produced catalepsy and sedation in a dose dependent manner. It displays greater efficacy than FAAH or MAGL specific inhibitors^[7].
动物研究
剂量
Mice: 5 mg/kg - 40 mg/kg^[3] (i.p.), 120 mg/kg^[4] (i.p.); 18 mg/kg, 30 mg/kg^[5] (s.c.)

给药途径
i.p., s.c.
参考文献

动物研究
剂量	Mice: 5 mg/kg - 40 mg/kg^[3] (i.p.), 120 mg/kg^[4] (i.p.); 18 mg/kg, 30 mg/kg^[5] (s.c.)
给药途径	i.p., s.c.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3070 mL
- 11.5352 mL
- 23.0704 mL
- 5 mM
- 0.4614 mL
- 2.3070 mL
- 4.6141 mL
- 10 mM
- 0.2307 mL
- 1.1535 mL
- 2.3070 mL

技术信息

CAS号

1210004-12-8

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H23N3O5

运输

蓝冰

分子量

433.46

别名

N/A

溶解度

DMSO	37.0 mg/mL (85.4 mM) warming
Water	insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

JZL 195 Catalog No. CSN17567

靶点选择性

请登录您的专属账户

确认信息