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CAS No.: 6730-83-2

Kaurenoic acid/异贝壳杉烯酸 Catalog No. CSN14103

Synonyms: Kaurenoic Acid;CCRIS 1514;Kauren-19-oic acid

Kaurenoic Acid is a natural product isolated and purified from the herbs of Croton antisyphiliticus with anti-inflammatory property, the mechanisms may through inhibition of iNOS and COX-2 expression. Kaurenoic acid is an inducer of apoptosis, which is part of the innate mechanism of cell defense against neoplasia. Kaurenoic acid from A. continentalis may be a useful agent for inhibiting the cariogenic properties of S. mutans.

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生物活性

描述Kaurenoic acid (KA) is a diterpene from Sphagneticola trilobata, inhibits Inflammatory Pain by the inhibition of cytokine production and activation of the NO–cyclic GMP–PKG–ATP-sensitive potassium channel signaling pathway^[3]. Kaurenoic acid dose-dependently inhibited NO production, PGE2 release, COX-2 and iNOS expression at micromolar concentrations in LPS-induced RAW264.7 macrophages with IC50 values of 51.73 (±2.42) μM and 106.09 (±0.27) μM in NO production and PGE(2) release, respectively^[4]. KA induced the phosphorylation of Smad2 and Smad3, key activator molecules in TGF-β signaling. Similarly, i.t. KA induced the phosphorylation of Smad2 and increased the expression of α-SMA in mouse lungs^[5]. KA increased, in a dose-dependent manner, the survival rate after acetaminophen overdose. KA reduced acetaminophen-induced hepatic necrosis and ALT and AST levels. KA decreased acetaminophen-induced neutrophil and macrophage recruitment, oxidative stress and the production of IL-33, TNF-α and IL-1β, alongside with normalisation of IL-10 levels in the liver^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.3063 mL
- 16.5316 mL
- 33.0632 mL
- 5 mM
- 0.6613 mL
- 3.3063 mL
- 6.6126 mL
- 10 mM
- 0.3306 mL
- 1.6532 mL
- 3.3063 mL

技术信息

CAS号

6730-83-2

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H30O2

运输

蓝冰

分子量

302.45

别名

Kaurenoic Acid;CCRIS 1514;Kauren-19-oic acid;异贝壳杉烯酸;贝壳杉烯酸

溶解度

DMSO	60.0 mg/mL (198.4 mM)

动物实验配方

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