|(R)-1-((2S,4aR,4bS,6S,8R,8aS)-6-羟基-8-(羟甲基)-2,4b,8-三甲基-2,3,4,4a,4b,5,6,7,8,8a,9,10-十二氢菲-2-基)乙烷-1,2-二醇|CsnPharm

CAS No.: 52659-56-0

Kirenol/奇任醇 Catalog No. CSN16605

Synonyms: 奇任醇;奇壬醇

Kirenol is a naturall occuring diterpenoid found in S. orientalis, which possess anti-oxidant, anti-inflammatory, anti-allergic, anti-adipogenic, and anti-arthritic activities.

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技术信息

生物活性

描述Kirenol is isolated from ethanolic extract of Siegesbeckia orientalis with anti-inflammatory and analgesic activity. The anti-inflammatory effect of kirenol 0.4 - 0.5% (w/w) was similar to the effect of piroxicam gel 4h after carrageenan injection^[3]. Kirenol treatment significantly decreased high glucose-induced cardiofibroblasts proliferation and increased the cardiomyocytes viability, prevented the loss of mitochondrial membrane potential and further attenuated cardiomyocytes apoptosis, accompanied by a reduction in apoptosis-related protein expression. Kirenol gavage could affect the expression of pro-inflammatory cytokines in a dose-dependent manner but not lower lipid profiles, and only decrease fasting plasma glucose, fasting plasma insulin and mean HbA1c levels in high-dose kirenol-treated group at some time-points^[4]. Kirenol inhibited the migration, invasion, and proinflammatory of IL-6 secretion of RA-associated synovial fibroblasts (FLS) at a concentration of 100 - 200 μg/ml in vitro. Proinflammatory cytokines production and synovium hyperplasia and cartilage erosion were also inhibited in a collagen-induced arthritis (CIA) mouse model upon kirenol treatment^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9544 mL
- 14.7719 mL
- 29.5437 mL
- 5 mM
- 0.5909 mL
- 2.9544 mL
- 5.9087 mL
- 10 mM
- 0.2954 mL
- 1.4772 mL
- 2.9544 mL

技术信息

CAS号

52659-56-0

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H34O4

运输

蓝冰

分子量

338.48

别名

奇任醇;奇壬醇

溶解度

DMSO	68.0 mg/mL (200.9 mM)

动物实验配方

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