|(3S,4S,4aR,6R,11BS,11CS)-2-甲基-11C-乙烯基-1,2,3,4,4a,5,6,11C-八氢-6,4-(环氧甲烷基)-3,11B-甲基苯丙胺[4,3-c]咔唑|CsnPharm

CAS No.: 1358-76-5

Koumine/钩吻素子 Catalog No. CSN14036

Synonyms: 钩吻素子

Koumine is an indole alkaloid isolated from Gelsemium elegans Benth., possessing analgesic, anti-inflammatory and neurosteroid modulating activities.

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400-920-2911

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生物活性

实验方案

技术信息

生物活性

描述Koumine, possess analgesic and anti-inflammatory properties, is an alkaloidal constituent derived from the medicinal plant Gelsemium elegans Benth. The analgesic effects of koumine on CCI-induced neuropathic pain may result from the inhibition of microglia activation and M1 polarization as well as the activation of astrocytes while sparing the anti-inflammatory responses to neuropathic pain^[3]. Repeated treatment with koumine significantly reduced and inhibited CCI-evoked (chronic constriction injury) astrocyte activation as well as the levels of pro-inflammatory cytokines. Intrathecal injection of an autophagy inhibitor (chloroquine) reversed the analgesic effect of koumine, as well as the inhibitory effect of koumine on astrocyte activation in the spinal cord^[4]. Both subcutaneous and intrathecal (i.t.) koumine treatment after incision significantly prevented mechanical allodynia and thermal hyperalgesia, inhibited microglial and astroglial activation, and suppressed expression of proinflammatory cytokines^[5]. Moreover, koumine might suppress the proliferation of HCC cells and promote apoptosis in HCC (hepatocellular carcinoma) cells dose-dependently^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2637 mL
- 16.3185 mL
- 32.6371 mL
- 5 mM
- 0.6527 mL
- 3.2637 mL
- 6.5274 mL
- 10 mM
- 0.3264 mL
- 1.6319 mL
- 3.2637 mL

技术信息

CAS号

1358-76-5

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H22N2O

运输

蓝冰

分子量

306.40

别名

钩吻素子

溶解度

DMSO	25.0 mg/mL (81.6 mM)

动物实验配方

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