CAS No.: 244192-94-7
L748337 Catalog No. CSN20251
Synonyms: L-748,337
L-748337 is a competitive β3-adrenoceptor antagonist that displays selectivity over β1 and β2 receptors (Ki values are 4.0, 204 and 390 nM for β3-, β2- and β1-adrenoceptors respectively). Inhibits cAMP accumulation in response to isoproterenol (IC50 = 6 nM). Reduces iNOS expression, attenuates nitric oxide-induced cell proliferation and induces apoptosis in a melanoma cell line.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Alexandre EC, Kiguti LR, et al. Mirabegron relaxes urethral smooth muscle by a dual mechanism involving β3 -adrenoceptor activation and α1-adrenoceptor blockade. Br J Pharmacol. 2016 Feb;173(3):415-28.
- [2] van Wieringen JP, Michel-Reher MB, et al. The new radioligand [(3)H] -L 748,337 differentially labels human and rat β3-adrenoceptors. Eur J Pharmacol. 2013 Nov 15;720(1-3):124-30.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 244192-94-7 | 储存条件 |
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| 分子式 | C26H31N3O5S | 运输 | 蓝冰 | |
| 分子量 | 497.61 | 别名 | L-748,337 |
