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CAS No.: 103890-78-4

Lacidipine/拉西地平 Catalog No. CSN11261

Synonyms: GX-1048;GR-43659X;SN-305

Lacidipine is a L-type calcium channel blocker, used for treating high blood pressure.

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生物活性

描述Lacidipine, a novel third-generation dihydropyridine calcium channel blocker used for hypertension. Lacidipine protects HKCs (human kidney cell) against apoptosis induced by ATP (adenosine triphosphate) depletion and recovery by regulating the caspase-3 pathway^[3]. In addition to calcium channel-modulated vasodilation, lacidipine displays antioxidant activity greater than that of other dihydropyridine calcium antagonists. Lacidipine was effective in elderly patients (including those with isolated systolic hypertension), African Nigerian patients and patients with concurrent type 2 diabetes mellitus. Lower atherosclerotic progression and plaque formation with lacidipine compared with atenolol in patients completing the full 4 years of the study^[4]. Lacidipine showed a significant reduction in elevated systolic blood pressure together with a great protection of ALT (alanine amine transferase) and SOD enzymes from the destructive effects of irradiation and hypertension in irradiated, hypertensive and lacidipine-treated rats^[5]. Lacidipine-modified EPCs (Endothelial progenitor cells) via a partially CXCR4 (CXC chemokine receptor four) signaling contribute to enhanced endothelial repair capacity in hypertension^[2]. In addition, lacidipine attenuates depression-like symptoms in reserpine-treated mice^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01587742	-	-	Completed	-	-
NCT00460915	Hypertension	Phase 4	Completed	-	Korea, Republic of ... more >> Korea University Guro Hospital Seoul, Korea, Republic of, 152-703 Collapse <<
NCT02218684	Healthy	Phase 1	Completed	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1952 mL
- 10.9759 mL
- 21.9518 mL
- 5 mM
- 0.4390 mL
- 2.1952 mL
- 4.3904 mL
- 10 mM
- 0.2195 mL
- 1.0976 mL
- 2.1952 mL

技术信息

CAS号

103890-78-4

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C26H33NO6

运输

蓝冰

分子量

455.54

别名

GX-1048;GR-43659X;SN-305;Lacipil;Lacimen;Motens;拉西地平

溶解度

DMSO	60.0 mg/mL (131.7 mM)
Water	insoluble

动物实验配方

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