|(+)-(Z)-2-((呋喃-2-基甲基)亚磺酰基)-N-(4-((4-(哌啶-1-基甲基)吡啶-2-基)氧基)丁-2-烯-1-基)乙酰胺|CsnPharm

CAS No.: 118288-08-7

Lafutidine/拉呋替丁 Catalog No. CSN11264

Synonyms: FRG-8813;trade name: Protecadin;Stogar

Lafutidine is an antagonist of histamine H(2)-receptor that inhibits gastric acid secretion.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Lafutidine, a histamine H2 receptor antagonist with mucosal protective properties via sensory afferent neurons, is used for the treatment of upper gastrointestinal diseases. Daily administration of lafutidine reduced the severity of intestinal mucositis, diarrhea and body weight loss in a dose-dependent manner. Lafutidine attenuates 5-FU-induced intestinal mucositis, most likely by increasing mucus production via activation of sensory afferent neurons^[3]. Lafutidine exhibited potent and long-lasting H2 antagonism and prolonged antisecretion. Lafutidine showed antiulcer activities against acute ulcer models, prevented gastric ulcer relapse of acetic ulcer, and accelerated the healing of indomethacin-induced antral ulcers in rats^[4]. Intracisternal injection of RX 77368 (1.5 ng) or intraportal lafutidine (10 mg/kg) by itself did not affect hepatic blood flow, but co-injection of intracisternal RX 77368 (1.5 ng) and intraportal lafutidine (5 mg/kg) increased it with peak response at 30 min postinjection. The effect of lafutidine on hepatic blood flow in rats given RX 77368 was dose-related over the range 1 - 5 mg/kg^[5]. Lafutidine, however, was superior to famotidine in terms of symptom relief of reflux esophagitis^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02703896	Pulmonary Aspiration of Gastri... more >>c Contents Collapse <<	Phase 4	Completed	-	-
NCT02555852	-	-	Completed	-	Canada, Quebec ... more >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 Collapse <<
NCT00229424	Gastroesophageal Reflux	Phase 3	Completed	-	Japan ... more >> Tohoku University Hospital 1-1, Seiryo-cho, Aoba-ku, Sendai, Miyagi, Japan, 980-8574 Collapse <<

更多
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3172 mL
- 11.5862 mL
- 23.1724 mL
- 5 mM
- 0.4634 mL
- 2.3172 mL
- 4.6345 mL
- 10 mM
- 0.2317 mL
- 1.1586 mL
- 2.3172 mL

技术信息

CAS号

118288-08-7

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H29N3O4S

运输

蓝冰

分子量

431.55

别名

FRG-8813;trade name: Protecadin;Stogar;拉呋替丁

溶解度

DMSO	85.0 mg/mL (197.0 mM)
Water	Insoluble
Ethanol	12.0 mg/mL (27.8 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Lafutidine/拉呋替丁 Catalog No. CSN11264

靶点选择性

请登录您的专属账户

确认信息