生物活性

• 描述HIV-1 integrase inhibitor, in the treatment of human immunodeficiency virus (HIV) infection.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00830804	HIV-1 Infections	Phase 2	Completed	-	United States, Alabama ... more >> AlabamaTherapeutics CRS Birmingham, Alabama, United States, 35294 United States, California Stanford CRS Palo Alto, California, United States, 94304 Ucsd, Avrc Crs San Diego, California, United States, 92103 Ucsf Aids Crs San Francisco, California, United States, 94110 United States, Colorado University of Colorado Hospital CRS Aurora, Colorado, United States, 80045 United States, District of Columbia Georgetown University CRS Washington, District of Columbia, United States, 20007 United States, Illinois Northwestern University CRS Chicago, Illinois, United States, 60611 United States, Massachusetts Beth Israel Deaconess Med Center Boston, Massachusetts, United States, 02115 Brigham and Women's Hosp. ACTG CRS Boston, Massachusetts, United States, 02115 United States, Missouri Washington U CRS Saint Louis, Missouri, United States, 63110 United States, New York AIDS Community Health Ctr. ACTG CRS Rochester, New York, United States, 14604 United States, North Carolina Unc Aids Crs Chapel Hill, North Carolina, United States, 27599 Duke Univ. Med. Ctr. Adult CRS Durham, North Carolina, United States, 27710 United States, Ohio Univ. of Cincinnati CRS Cincinnati, Ohio, United States, 45267-0405 Case CRS Cleveland, Ohio, United States, 44106 MetroHealth CRS Cleveland, Ohio, United States, 44109 The Ohio State Univ. AIDS CRS Columbus, Ohio, United States, 43210 United States, Pennsylvania Hosp. of the Univ. of Pennsylvania CRS Philadelphia, Pennsylvania, United States, 19104 University of Pittsburgh CTU Pittsburgh, Pennsylvania, United States, 15213 United States, Rhode Island The Miriam Hospital Providence, Rhode Island, United States, 02906 United States, Tennessee Vanderbilt Therapeutics CRS Nashville, Tennessee, United States, 37203 United States, Texas Houston AIDS Research Team Houston, Texas, United States, 77030 Collapse <<
  NCT00830804	-	-	Completed	-	-
  NCT02116660	HIV Infections	Phase 2	Completed	-	-

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• 参考文献

• [1] Hu G, Li X, et al. Discovery of inhibitors to block interactions of HIV-1 integrase with human LEDGF/p75 via structure-based virtual screening and bioassays. J Med Chem. 2012 Nov 26;55(22):10108-17.

  [2] Christ F, Voet A, et al. Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication. Nat Chem Biol. 2010 Jun;6(6):442-8.