CAS No.: 75706-12-6
Leflunomide/来氟米特 Catalog No. CSN16462
Synonyms: HWA486;RS-34821;SU101
Leflunomide is a dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 2.5 μM, it is a disease-modifying antirheumatic drug (DMARD) and inhibits de novo pyrimidine synthesis.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01557348 - - Completed - - NCT01557348 - - Completed - - NCT01500551 Juvenile Idiopathic Arthritis Phase 3 Recruiting March 31, 2021 - - 更多
- 参考文献
- [1] Davis JP, Cain GA, et al. The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry. 1996 Jan 30;35(4):1270-3.
- [2] Xu X, Williams JW, et al. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. J Biol Chem. 1995 May 26;270(21):12398-403.
- [3] Cannon GW, Kremer JM. Leflunomide. Rheum Dis Clin North Am. 2004 May;30(2):295-309, vi
- [4] Liang C, Li J, Lu C, Xie D, Liu J, Zhong C, Wu X, Dai R, Zhang H, Guan D, Guo B, He B, Li F, He X, Zhang W, Zhang BT, Zhang G, Lu A. HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis. Nat Commun. 2019 Oct 8;10(1):4579
- [5] Elshaer RE, Tawfik MK, Nosseir N, El-Ghaiesh SH, Toraih EA, Elsherbiny NM, Zaitone SA. Leflunomide-induced liver injury in mice: Involvement of TLR4 mediated activation of PI3K/mTOR/NFκB pathway. Life Sci. 2019 Oct 15;235:116824
- [6] Zhang M, Qi C, Zha Y, Chen J, Luo P, Wang L, Sun Z, Wan J, Xing C, Wang S, Jiang G, Sun M, Chen Q, Chen J, Li D, Guan T, Ni Z. Leflunomide versus cyclophosphamide in the induction treatment of proliferative lupus nephritis in Chinese patients: a randomized trial. Clin Rheumatol. 2019 Mar;38(3):859-867
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 75706-12-6 | 储存条件 |
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| 分子式 | C12H9F3N2O2 | 运输 | 蓝冰 | |||||||
| 分子量 | 270.21 | 别名 | HWA486;RS-34821;SU101;HW 486;Arava;Leflunomidum;来氟米特 | |||||||
| 溶解度 |
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动物实验配方 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT01557348 | - | - | Completed | - | - |
| NCT01557348 | - | - | Completed | - | - |
| NCT01500551 | Juvenile Idiopathic Arthritis | Phase 3 | Recruiting | March 31, 2021 | - |
| NCT02590562 | - | - | Completed | - | - |
| NCT01640548 | - | - | Completed | - | United Kingdom ... more >> Abergavenny, United Kingdom, NP7 7EG Basildon, United Kingdom, SS16 5NL Basingstoke, United Kingdom, RG24 9NA Belfast, United Kingdom, BT9 7JB Blackburn, United Kingdom, BB2 3HH Bournemouth, United Kingdom, BH7 7DW Cambridge, United Kingdom, CB2 2QQ Cannock, United Kingdom, WS11 5XY Dewsbury, United Kingdom, WF13 4HS Dudley, United Kingdom, DY1 2HQ Durham, United Kingdom, DH15TW Eastbourne, United Kingdom, BN21 2UD Edinburgh, United Kingdom, EH4 2XU Glasgow, United Kingdom, G12 0YN Greenock, United Kingdom, PA16 0XN Harlow, United Kingdom, CM20 1QX Inverness, United Kingdom, IV2 3UV Kirkcaldy, United Kingdom, KY2 5AH London, United Kingdom, SE18 4QH Portsmouth, United Kingdom, PO6 3LY Sheffield, United Kingdom, S10 2JF Truro, United Kingdom, TR1 3LJ Warrington, United Kingdom, WA5 1QG Westbury-on-Trym, Bristol, United Kingdom, BS10 5NB Wigan, United Kingdom, WN6 9EW Wolverhampton, United Kingdom, WV10 0QP Collapse << |
| NCT02590562 | - | - | Completed | - | China ... more >> Peking University First Hospital Beijing, China, 100034 Beijing Jishutan Hospital; Rheumatology & Immunology Beijing, China, 100035 Peking University People's Hospital Beijing, China, 100044 Peking University Third Hospital Beijing, China, 100083 China-Janpan Friendship Hospital of Jilin University Changchun, China, 130031 West China Hospital, Sichuan University Chengdu, China, 610041 Sichuan Provincial People's Hospital Chengdu, China, 610072 The First Affiliated Hospital, Sun Yat-sen University Guangzhou, China, 510080 The First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou, China, 510405 Nanfang Hospital, Southern Medical University Guangzhou, China, 510515 Guanghua Hospital of Integrated Traditional Chinese and Western Medicine ( Guanghua Hospital) Shanghai, China, 200052 The Second Hospital of Shanxi Medical University Taiyuan, China, 030001 Tianjin Medical University General Hospital Tianjin (天津), China, 300052 First Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an, China, 710061 Xinjiang Uygur Autonomous Region People Hospital Ürümqi, China, 830001 Collapse << |
| NCT01664117 | - | - | Completed | - | Spain ... more >> Vitoria, Alava, Spain, 01009 Elche, Alicante, Spain, 03203 Oviedo, Asturias, Spain, 33006 Zafra, Badajoz, Spain, 06300 Sabadell, Barcelona, Spain, 08208 Viladecans, Barcelona, Spain, 08840 Jerez de la Frontera, Cadiz, Spain, 11407 Vinaroz, Castellon, Spain, 12500 Cenes de la vega, Granada, Spain, 18190 Granda, Granada, Spain, 18190 San Sebastian, Guipuzcoa, Spain, 20080 Ibiza, Islas Baleares, Spain, 07800 Inca, Islas Baleares, Spain, 07300 Manacor (Islas Baleares), Islas Baleares, Spain, 07500 Jaén, Jaen, Spain, 23007 La Coruna, La Coruña, Spain, 15006 Alcala de Henares, Madrid, Spain, 28805 Benalmadena, Malaga, Spain, 29630 Vigo, Pontevedra, Spain, 36214 Gandia, Valencia, Spain, 46700 Alicante, Spain, 03010 Burgos, Spain, 06006 Caceres, Spain, 10310 Cordoba, Spain, 14001 Girona, Spain, 17007 Madrid, Spain, 28006 Madrid, Spain, 28007 Madrid, Spain, 28034 Madrid, Spain, 28222 Madrid, Spain, 28905 Malaga, Spain, 29005 Murcia, Spain, 30008 Palencia, Spain, 34005 Sevilla, Spain, 41013 Sevilla, Spain, 41018 Tenerife, Spain, 38010 Toledo, Spain, 45004 Valencia, Spain, 46015 Valladolid, Spain, 47005 Zamora, Spain, 49022 Zaragoza, Spain, 50009 Collapse << |
| NCT01640548 | - | - | Completed | - | - |
| NCT01664117 | - | - | Completed | - | - |
| NCT01474291 | - | - | Completed | - | - |
| NCT00975130 | Arthritis, Rheumatoid | Phase 3 | Completed | - | - |
| NCT00975130 | - | - | Completed | - | - |
| NCT00816465 | Non-Alcoholic Fatty Liver Dise... more >>ase Collapse << | Phase 1 | Completed | - | Israel ... more >> Hadassah Medical Center Jerusalem, Israel, 91120 Collapse << |
| NCT01211834 | Rheumatoid Arthritis | Phase 3 | Completed | - | Korea, Republic of ... more >> Seoul National Univ. Hospital Seoul, Korea, Republic of, 110-744 Collapse << |
| NCT00720798 | Rheumatoid Arthritis | Phase 3 | Completed | - | - |
| NCT01399281 | - | - | Recruiting | December 2021 | Italy ... more >> IRCCS G. Gaslini Recruiting Genoa, Italy, 16147 Principal Investigator: Nicola Ruperto, MD, MPH Collapse << |
| NCT02873936 | Rheumatoid Arthritis | Phase 3 | Completed | - | - |
| NCT00124982 | - | - | Completed | - | - |
| NCT01474291 | - | - | Completed | - | - |
| NCT01313208 | Rheumatoid Arthritis | Phase 4 | Completed | - | - |
| NCT00720798 | - | - | Completed | - | - |
| NCT03449758 | Rheumatoid Arthritis | Phase 4 | Recruiting | July 31, 2019 | France ... more >> Investigational Site Number 250007 Recruiting Argenteuil, France Investigational Site Number 250006 Recruiting Besancon, France, 25030 Investigational Site Number 250027 Recruiting Bobigny, France, 93000 Investigational Site Number 250016 Recruiting Bordeaux, France, 33076 Investigational Site Number 250014 Recruiting Caen, France, 14033 Investigational Site Number 250019 Recruiting Cannes, France, 06414 Investigational Site Number 250013 Recruiting Cholet, France, 49325 Investigational Site Number 250002 Recruiting Clermont Ferrand, France, 63003 Investigational Site Number 250009 Recruiting Echirolles, France, 38434 Investigational Site Number 250005 Recruiting La Roche Sur Yon, France, 85025 Investigational Site Number 250004 Recruiting Lille Cedex, France, 59037 Investigational Site Number 250012 Recruiting Limoges Cedex, France, 87000 Investigational Site Number 250021 Recruiting Lyon, France, 69495 Investigational Site Number 250018 Recruiting Montivilliers, France Investigational Site Number 250029 Recruiting MONTPELLIER Cedex 5, France, 34295 Investigational Site Number 250025 Recruiting NANTES Cedex 1, France, 44035 Investigational Site Number 250026 Recruiting Nice cedex 1, France, 06001 Investigational Site Number 250020 Recruiting Paris Cedex 10, France, 75475 Investigational Site Number 250011 Recruiting PARIS Cedex 13, France, 75013 Investigational Site Number 250010 Recruiting Paris, France, 75012 Investigational Site Number 250015 Recruiting Paris, France, 75014 Investigational Site Number 250028 Recruiting Paris, France, 75015 Investigational Site Number 250031 Recruiting Poitiers, France, 86021 Investigational Site Number 250023 Recruiting Pontoise, France, 95300 Investigational Site Number 250017 Recruiting RENNES Cedex, France, 35022 Investigational Site Number 250008 Recruiting Rouen, France, 76000 Investigational Site Number 250001 Recruiting St Etienne, France, 42055 Investigational Site Number 250022 Recruiting Toulouse, France, 31200 Investigational Site Number 250003 Recruiting Tours, France, 37000 Collapse << |
| NCT00531817 | - | - | Completed | - | - |
| NCT00124982 | Rheumatoid Arthritis | Phase 3 | Completed | - | - |
| NCT02779114 | Rheumatoid Arthritis | Phase 3 | Unknown | June 2018 | Germany ... more >> Asklepios Klinikum Bad Abbach Recruiting Bad Abbach, Germany Contact: Martin Fleck, Prof. Dr. med. Rheumapraxis Manger Recruiting Bamberg, Germany Contact: Karin Manger, Prof. Dr. med. Rheumapraxis Bayreuth Recruiting Bayreuth, Germany Contact: Wolfgang Ochs, Dr. med. Contact: Matthias Schmitt-Haendle, Dr. med. Schlosspark-Klinik Recruiting Berlin, Germany Contact: Rieke Alten, Dr. med. Schwerpunktpraxis für Rheumatologie Burghausen Recruiting Burghausen, Germany Contact: Martin Feuchtenberger, Dr. med. PGRN.de Praxisgemeinschaft Rheumatologie Nephrologie Recruiting Erlangen, Germany Contact: Joerg Wendler, Dr. med. Contact: Florian Schuch, Dr. med. Sub-Investigator: Stefan Kleinert, Dr. med. Universitätsklinikum Heidelberg; Medizinische Klinik V Recruiting Heidelberg, Germany Contact: Hanns-Martin Lorenz, Prof. Dr. med. Gemeinschaftspraxis Dres. Demary und von Hinüber Recruiting Hildesheim, Germany Contact: Winfried Demary, Dr. med. Praxiszentrum St. Bonifatius Recruiting München, Germany Contact: Klaus Krüger, Prof. Dr. med. Praxis Professor Nüsslein Recruiting Nürnberg, Germany Contact: Hubert Nüsslein, Prof. Dr. med. Universitätsklinikum Tübingen; Zentrum für Interdisziplinäre Klinische Immunologie, Rheumatologie und Autoimmunerkrankungen - INDIRA Recruiting Tübingen, Germany Contact: Joerg Henes, Dr. med. Medizinische Klinik 2 und Poliklinik, Universitätsklinikum Würzburg Recruiting Würzburg, Germany Contact: Hans-Peter Tony, Prof.Dr.med. Contact: Marc Schmalzing, Dr. med. Collapse << |
| NCT01914770 | - | - | Completed | - | - |
| NCT02885610 | Systemic Lupus Erythematosus | Phase 2 | Recruiting | December 2019 | China, Beijing ... more >> Peking Union Medical College Hospital Recruiting Beijing, Beijing, China Contact: Fengchun Zhang Collapse << |
| NCT01313208 | - | - | Completed | - | - |
| NCT03058900 | Psoriatic Arthritis | Not Applicable | Recruiting | July 1, 2019 | Denmark ... more >> Dept. of Rheumatology at Odense University Hospital Recruiting Odense, Denmark, 5000 Contact: Torkell J. Ellingsen, Prof PhD torkell.ellingsen@rsyd.dk Contact: Maja S. Kragsnaes, PhD student maja.kragsnaes@dadlnet.dk Sub-Investigator: Maja S. Kragsnaes, PhD student Principal Investigator: Torkell J. Ellingsen, Prof PhD Diagnostic Centre at Silkeborg Regional Hospital Not yet recruiting Silkeborg, Denmark, 8600 Contact: Maja S. Kragsnaes, PhD student Collapse << |
| NCT02293590 | Rheumatoid Arthritis | Phase 2 | Completed | - | Switzerland ... more >> Kantonsspital St. Gallen St. Gallen, Saint Gallen, Switzerland, 9007 Collapse << |
| NCT00531817 | Rheumatoid Arthritis | Phase 3 | Completed | - | - |
| NCT00706797 | Rheumatoid Arthritis | Phase 4 | Terminated | - | - |
| NCT01646385 | - | - | Completed | - | - |
| NCT00706797 | - | - | Terminated | - | - |
| NCT03736044 | Rheumatoid Arthritis | Not Applicable | Completed | - | - |
| NCT01646385 | - | - | Completed | - | - |
| NCT03531073 | - | - | Recruiting | April 2023 | United Kingdom ... more >> Oxford University Hospitals NHS Trust Recruiting Oxford, Oxfordshire, United Kingdom, OX3 7LD Contact: Laura C Coates, MBChB 01865737838 laura.coates@ndorms.ox.ac.uk Contact: Marion Watson 01865737905 marion.watson@ndorms.ox.ac.uk Collapse << |
| NCT00551707 | Rheumatoid Arthritis | Phase 2 | Completed | - | - |
| NCT00056602 | - | - | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
| NCT00551707 | - | - | Completed | - | - |
| NCT03555227 | Breast Cancer Female | Not Applicable | Completed | - | United Kingdom ... more >> Craigavon Area Hospital Portadown, Northern Ireland, United Kingdom, BT63 5QQ Collapse << |
| NCT02373202 | Rheumatoid Arthritis | Phase 3 | Completed | - | Japan ... more >> Investigational Site Number 392010 Asahi-Shi, Japan Investigational Site Number 392001 Asahikawa-Shi, Japan Investigational Site Number 392070 Beppu-Shi, Japan Investigational Site Number 392036 Chiba-Shi, Japan Investigational Site Number 392083 Chuo-Ku, Japan Investigational Site Number 392004 Fukui-Shi, Japan Investigational Site Number 392039 Fukuoka-Shi, Japan Investigational Site Number 392030 Ichinomiya-Shi, Japan Investigational Site Number 392002 Iizuka-Shi, Japan Investigational Site Number 392019 Kagoshima-Shi, Japan Investigational Site Number 392066 Kamakura-Shi, Japan Investigational Site Number 392050 Kato-Shi, Japan Investigational Site Number 392037 Kawachi-Nagano-Shi, Japan Investigational Site Number 392099 Kawasaki-Shi, Japan Investigational Site Number 392013 Kitakyushu-Shi, Japan Investigational Site Number 392097 Kochi-Shi, Japan Investigational Site Number 392065 Kushiro-Shi, Japan Investigational Site Number 392026 Matsuyama-Shi, Japan Investigational Site Number 392034 Miyagi-Gun, Japan Investigational Site Number 392076 Nagoya-Shi, Japan Investigational Site Number 392080 Nagoya-Shi, Japan Investigational Site Number 392046 Narashino-Shi, Japan Investigational Site Number 392059 Oita-Shi, Japan Investigational Site Number 392062 Okayama-Shi, Japan Investigational Site Number 392027 Osaki-Shi, Japan Investigational Site Number 392049 Sagamihara-Shi, Japan Investigational Site Number 392014 Sapporo-Shi, Japan Investigational Site Number 392041 Sapporo-Shi, Japan Investigational Site Number 392073 Sapporo-Shi, Japan Investigational Site Number 392006 Sasebo-Shi, Japan Investigational Site Number 392021 Sendai-Shi, Japan Investigational Site Number 392022 Sendai-Shi, Japan Investigational Site Number 392033 Sendai-Shi, Japan Investigational Site Number 392071 Sendai-Shi, Japan Investigational Site Number 392029 Shizuoka-Shi, Japan Investigational Site Number 392023 Takaoka-Shi, Japan Investigational Site Number 392003 Tomakomai-Shi, Japan Investigational Site Number 392074 Urasoe-Shi, Japan Investigational Site Number 392079 Urayasu-Shi, Japan Investigational Site Number 392048 Yokohama-Shi, Japan Collapse << |
| NCT00443651 | - | - | Completed | - | - |
| NCT02839226 | Wounds Other ... more >>Ulcers Wounds and Skin Problems Collapse << | Phase 2 | Unknown | December 2017 | Israel ... more >> Sourasky Medical Center Recruiting Tel Aviv, Israel, 96105 Contact: Eyal Gur, MD Gur@tlvmc.gov.il Contact: Meirav Sela, MSc meiravs@tlvmc.gov.il Principal Investigator: Eyal Gur, MD Sub-Investigator: Eran Otremsky, MD Collapse << |
| NCT02373202 | - | - | Completed | - | - |
| NCT01256736 | Rheumatoid Arthritis | Phase 3 | Completed | - | Korea, Republic of ... more >> Seoul National Univ. Hospital Seoul, Korea, Republic of, 110-744 Collapse << |
| NCT02057250 | RA | Phase 3 | Completed | - | - |
| NCT01040195 | Seronegative Spondyloarthropat... more >>hies Collapse << | Phase 3 | Completed | - | India ... more >> Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow, UP, India, 226014 Collapse << |
| NCT02057250 | - | - | Completed | - | - |
| NCT01225393 | Rheumatoid Arthritis | Phase 2 | Completed | - | - |
| NCT03191539 | Arthritis; Psoriasis (Etiology... more >>) Collapse << | Phase 3 | Not yet recruiting | June 14, 2019 | - |
| NCT01768572 | Rheumatoid Arthritis | Phase 3 | Completed | - | - |
| NCT02602184 | Wounds and Injuries | Phase 2 | Unknown | June 2017 | United States, Illinois ... more >> Northwestern University Feinberg School of Medicine Recruiting Chicago, Illinois, United States, 60611 Contact: Robert Galiano, MD FACS 312-695-6022 rgaliano@nmh.org Contact: Jing Liu, MD 312-695-3908 jiliu@nmh.org Collapse << |
| NCT01768572 | - | - | Completed | - | - |
| NCT00443651 | Rheumatoid Arthritis | Phase 3 | Completed | - | - |
| NCT01941095 | - | - | Completed | - | - |
| NCT02878161 | Rheumatoid Arthritis | Phase 4 | Enrolling by invitation | December 2019 | - |
| NCT01941095 | Rheumatoid Arthritis | Phase 3 | Completed | - | Greece ... more >> District Gen. Hosp. of Athens Laiko; A Propedeutic Internal Medicine Clinic & Research Center Athens, Greece, 115 27 Laiko General Hospital; Dept. of Pathophysiology-Uni of Athens Athens, Greece, 115 27 Hippokratio Hospital; 2Nd Internal Medicine Athens, Greece, 11527 ATTIKO Hospital_4th University Internal Medicine Clinic Haidari, Greece, 124 62 Uni General Hospital of Heraklion; Medicine and Rheumatology Clinical Immunology and Allergy Dept Heraklion, Greece, 711 10 Uni Hospital of Ioannina; Rheumatology Ioannina, Greece, 455 00 University General Hospital of Larissa; Rheumatology Unit Larissa, Greece, 411 10 University Hospital of Patras; Rheumatology Patras, Greece, 265 04 EUROMEDICA Geniki Kliniki Thessalonikis; Rheumatology Department Thessaloniki, Greece, 544 65 General Hospital of Thessaloniki HIPPOKRATIO; Clinical Immunology Unit,2nd Dept of Internal Medicine Thessaloniki, Greece, 546 42 Collapse << |
| NCT01709578 | Rheumatoid Arthritis | Phase 3 | Completed | - | - |
| NCT00269165 | Aortic Valve Stenosis | Phase 3 | Terminated | - | - |
| NCT01834157 | - | - | Unknown | November 2017 | - |
| NCT00521924 | Rheumatoid Arthritis | Phase 3 | Terminated(Slow Enrollment) | - | - |
| NCT01709578 | - | - | Completed | - | - |
| NCT00521924 | - | - | Terminated(Slow Enrollment) | - | - |
| NCT02532777 | Henoch-Schoenlein Purpura Neph... more >>ritis Collapse << | Phase 2 | Recruiting | July 2020 | China, Jiangsu ... more >> Nanjing Children's Hospital Recruiting Nanjing, Jiangsu, China, 210000 Contact: Aihua Zhang, M.D. +8618951769017 bszah@163.com Collapse << |
| NCT01619176 | Rheumatoid Arthritis | Not Applicable | Completed | - | China, Shanghai ... more >> Shanghai GuangHua Hospital of integrated traditional and western medicine Shanghai, Shanghai, China, 200052 Collapse << |
| NCT03739853 | Psoriatic Arthritis | Phase 4 | Not yet recruiting | February 2022 | - |
| NCT00230035 | Systemic Lupus Erythematosus | Phase 2 | Withdrawn(Recommended by DSMB ... more >>due to lack of accrual) Collapse << | - | United States, California ... more >> UCSD, Thornton Hospital La Jolla, California, United States, 92037-0943 UCLA, Rehabilitation Center Los Angeles, California, United States, 90095-1670 United States, Illinois Northwestern University Chicago, Illinois, United States, 60611 United States, New York Feinstein Institute for Medical Research NS-LIJ Health System Manhassat, New York, United States, 11030 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27709 Collapse << |
| NCT00476996 | Rheumatoid Arthritis | Phase 3 | Completed | - | - |
| NCT01172639 | Rheumatoid Arthritis | Phase 4 | Completed | - | Belgium ... more >> ASZ Aalst, Belgium, 9300 OLV Ziekenhuis Aalst, Belgium, 9300 Imelda Ziekenhuis Bonheiden, Belgium, 2820 AZ St Lucas Brugge, Belgium, 8310 Reuma praktijk Genk, Belgium, 3600 Reumacentrum Genk, Belgium, 3600 UZ Gent, dept. of Rheumatology Gent, Belgium, 9000 Reuma instituut Hasselt Hasselt, Belgium, 3500 Reumapraktijk Hasselt, Belgium, 3500 Jan Yperman Ziekenhuis Ieper, Belgium, 8900 AZ groeninge Kortrijk, Belgium, 8500 HHart Ziekenhuis Leuven, Belgium, 3000 MCH Leuven, Belgium, 3000 Universitaire Ziekenhuizen Leuven Leuven, Belgium, 3000 AZ St maarten Mechelen, Belgium, 2800 ZNA Jan Palfijn Merksem, Belgium, 2170 Henri Serruys ziekenhuis Oostende, Belgium, 8400 Collapse << |
| NCT00422227 | Rheumatoid Arthritis | Phase 4 | Completed | - | Hong Kong ... more >> Hong Kong, Hong Kong India Bangalore, India, 560017 Bangalore, India, 560034 Hyderabaad, India, 500082 New Delhi, India, 110029 Korea, Republic of In Cheon, Korea, Korea, Republic of, 400-711 Seoul, Korea, Korea, Republic of, 110-744 Seoul, Korea, Korea, Republic of, 120-752 Seoul, Korea, Korea, Republic of, 133-792 Seoul, Korea, Korea, Republic of, 137-701 Seoul, Korea, Korea, Republic of, 138-736 Malaysia Ipoh, Perak, Malaysia, 30450 Kuala Lumpur, Malaysia, 68100 Pulau Pinang, Malaysia, 10450 Putrajaya, Malaysia, 62250 Seremban, Malaysia, 70300 Philippines Cebu, Philippines, 6000 Makati City, Philippines, 1200 Manila, Philippines, 1000 Manila, Philippines, 1004 Manila, Philippines, 1500 Quezon City, Philippines, 1102 Singapore Singapore, Singapore, 308433 Taiwan Kaohsiung City, Taiwan, 807 Taipei, Taiwan, 100 Taipei, Taiwan, 112 Thailand Bangkok, Thailand, 10400 Collapse << |
| NCT01172639 | - | - | Completed | - | - |
| NCT00422227 | - | - | Completed | - | - |
| NCT01033656 | Adult-Onset Still's Disease | Phase 2 | Completed | - | Sweden ... more >> Ann Kataja Knight Uppsala, Sweden, 75185 Collapse << |
| NCT02644499 | Rheumatoid Arthritis | Phase 4 | Completed | - | India ... more >> Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER) Pondicherry, Pondicherry UT, India, 605006 Collapse << |
| NCT03649061 | Arthritis, Rheumatoid | Phase 4 | Recruiting | December 2022 | Belgium ... more >> Imelda Ziekenhuis Bonheiden Not yet recruiting Bonheiden, Antwerpen, Belgium, 2820 Contact: Els Van Essche, MD Sub-Investigator: Kathleen Declerck, MD Sub-Investigator: Stijn Michiels, MD UZA Not yet recruiting Edegem, Antwerpen, Belgium, 2650 Contact: Luc De Clerck, MD, PhD AZ Herentals Not yet recruiting Herentals, Antwerpen, Belgium, 2200 Contact: Luk Corluy, MD ZNA Jan Palfijn Not yet recruiting Merksem, Antwerpen, Belgium, 2170 Contact: Kurt de Vlam, MD, PhD Sub-Investigator: Rik Joos, MD, PhD Sub-Investigator: Elke Geens, MD GHdC Saint Joseph Not yet recruiting Gilly, Henegouwen, Belgium, 6060 Contact: Marc Vanden Berghe, MD Reuma centrum Genk Not yet recruiting Genk, Limburg, Belgium, 3600 Contact: Philip Remans, MD, PhD Reuma Clinic Genk Not yet recruiting Genk, Limburg, Belgium, 3600 Contact: Johan Vanhoof, MD Sub-Investigator: Marleen Coppens, MD Sub-Investigator: Pascale Volders, MD Sub-Investigator: Anne Sileghem, MD Sub-Investigator: Piet Geusens, MD, PhD Reuma Instituut Hasselt Not yet recruiting Hasselt, Limburg, Belgium, 3500 Contact: Jan Lenaerts, MD Sub-Investigator: Isabelle De Wergifosse, MD Sub-Investigator: Christine Langenaken, MD OLV Ziekenhuis Aalst Not yet recruiting Aalst, Oost Vlaanderen, Belgium, 9300 Contact: Tom Zwaenepoel, MD Sub-Investigator: Isabelle Ravelingien, MD Sub-Investigator: Bert Vander Cruysse, MD, PhD Sub-Investigator: Murielle Stubbe, MD Sub-Investigator: Marijke Van Hoydonck, MD Regionaal Ziekenhuis Heilig Hart Leuven Not yet recruiting Leuven, Vlaams Brabant, Belgium, 3000 Contact: Veerle Taelman, MD UZ Leuven Recruiting Leuven, Vlaams Brabant, Belgium, 3000 Contact: Patrick Verschueren, MD, PhD +32 16 34 25 41 patrick.verschueren@uzleuven.be Sub-Investigator: Rene Westhovens, MD, PhD AZ St Lucas Brugge Not yet recruiting Brugge, West Vlaanderen, Belgium, 8310 Contact: Caroline Verbist, MD Sub-Investigator: Bea Mayaert, MD Sub-Investigator: Mieke Devinck, MD CHU Saint Pierre Not yet recruiting Brussel, Belgium, 1000 Contact: Silvana Di Romana, MD Cliniques Universitaire Saint Luc (UCL) Not yet recruiting Brussel, Belgium, 1000 Contact: Patrick Durez, MD, PhD Sub-Investigator: Bernard Lauwerys, MD, PhD CHU Liège Not yet recruiting Liège, Belgium, 4000 Contact: Michel Malaise, MD, PhD Collapse << |
| NCT02930343 | Rheumatoid Arthritis | Phase 4 | Recruiting | August 2018 | India ... more >> Department of Clinical Immunology , Jawaharlal Institute of Post graduate Medical Educationa and Research Recruiting Pondicherry, India, 605006 Contact: Dr. Vir Singh Negi, DM 0413-2297358 vsnegi22@yahoo.co.in Contact: Dr. Pooja Belani, MD 8940482248 drpoojabelani@gmail.com Collapse << |
| NCT01774877 | Rheumatoid Arthritis | Not Applicable | Completed | - | China, Anhui ... more >> The first affiliated hospital of bengbu medical college Bengbu, Anhui, China, 233004 The first affiliated hospital of anhui medical university Hefei, Anhui, China, 230031 Yijishan Hospital of Wannan Medical College Wuhu, Anhui, China, 241001 Collapse << |
| NCT01600521 | Rheumatoid Arthritis | Not Applicable | Completed | - | China ... more >> Beijing Friendship Hospital, Affiliated to Capital Medical University Beijing, China, 100050 Institute of Chinese Medical Sciences, University of Macau Taipa, China Collapse << |
| NCT00003293 | Brain and Central Nervous Syst... more >>em Tumors Collapse << | Phase 3 | Completed | - | - |
| NCT00001573 | Glioma Sarcom... more >>a Collapse << | Phase 1 | Completed | - | United States, Maryland ... more >> National Cancer Institute (NCI) Bethesda, Maryland, United States, 20892 Collapse << |
| NCT00451971 | Arthritis, Rheumatoid | Phase 4 | Completed | - | Australia ... more >> Sanofi-Aventis Sydney, Australia Collapse << |
| NCT00684372 | Terminal Renal Failure ... more >> BK Virus Infection Collapse << | Not Applicable | Unknown | May 2009 | Sweden ... more >> Karolinska University Hospital Stockholm, Sweden, 14186 Collapse << |
| NCT00004071 | Prostate Cancer | Phase 2 Phase 3 | Completed | - | United States, Florida ... more >> Comprehensive Cancer Care Specialists of Boca Raton Boca Raton, Florida, United States, 33428 Florida Cancer Specialists Fort Myers, Florida, United States, 33901 United States, New York St. Vincents Comprehensive Cancer Center New York, New York, United States, 10011 Collapse << |
| NCT01617590 | Rheumatoid Arthritis | Not Applicable | Unknown | May 2014 | China, Shanxi ... more >> rheumatism department,Second hospital of Shanxi medical university Recruiting TaiYuan, Shanxi, China, 030001 Contact: li xiao feng 086-0351-3074231 lixiaofeng_sxey@163.com Collapse << |
| NCT01244958 | Rheumatoid Arthritis | Phase 3 | Completed | - | Germany ... more >> Schwerpunktpraxis Bad Kösen, Sachsen-Anhalt, Germany, 06628 Kerckhoff-Klinik GmbH Abtlg. Rheumatologie und Klin. Immunologie Bad Nauheim, Germany Rheumazentrum Baden-Baden Baden-Baden, Germany Praxis Remstedt Berlin, Germany Rheumaklinik Berlin-Buch Immanuel Krankenhaus Berlin, Germany Schlosspark-Klinik Berlin, Germany Universitätsmedizin Berlin-Campus Charité Berlin, Germany Krankenhaus Friedrichstadt Dresden, Germany Rheumatologische Schwerpunktpraxis Erlangen, Germany Department of Medicine II / Rheumatology Johann Wolfgang Goethe-Universität Frankfurt, Germany, 60528 Rheumatologie Endokrinologikum Frankfurt Frankfurt, Germany Universität Freiburg Innere Medizin - Abtlg. Rheumatologie Freiburg, Germany Gemeinschaftspraxis für Innere Medizin Gießen, Germany Praxis, Innere Medizin und Rheumatologie Goslar, Germany Klinik u. Poliklinik f. Innere Medizin A, Nephrologie u. Rheumatolog Uniklinik Greifswald Greifswald, Germany Universitätsmedizin Göttingen Georg-August-Universität Abtlg. Nephrologie u. Rheumatologie Göttingen, Germany Uniklinik Halle - Poliklinik für Innere Medizin I Halle, Germany Medizinische Hochschule Hannover Klinik f. Immunologie u. Rheumatologie Hannover, Germany Rheumapraxis Heidelberg Heidelberg, Germany Praxis, Innere Medizin und Rheumatologie Hildesheim, Germany Internistisch - Rheumatologische Praxis Hofheim, Germany Klinik für Innere Medizin I Universitätsklinikum des Saarlandes Homburg, Germany Rheumapraxis Karlsruhe Karlsruhe, Germany Krankenhaus Porz am Rhein Köln, Germany Universitätsklinikum Köln Med I Köln, Germany Universität Leipzig Leipzig, Germany Praxis Kaufmann Ludwigsfelde, Germany Medizinsche Klinik A, Rheumatologie, Nephrologie Klinikum der Stadt Ludwigshafen, Ludwigshafen, Germany Katholisches Klinikum Mainz, St. Vincenz und Elisabeth Hospital Mainz, Germany Praxis Prof. Dr. Kellner München, Germany Praxiszentrum St. Bonifatius München, Germany Rheumatologische Schwerpunktpraxis Neuss, Germany Klinikum Offenbach GmbH Offenbach, Germany Praxis. Gauler und Fliedner Osnabrück, Germany Praxis Gräßler Pirna, Germany Rheumatologie Praxis Planegg, Germany Evangelisches Fachkrankenhaus Ratingen, Germany Uni Klinik Regensburg Regensburg, Germany Krankenhaus der Barmherzigen Brüder Trier Trier, Germany Abt. II Medizinische Universitätsklinik und Poliklinik Tübingen, Germany Universitätsklinikum Ulm Klinik f. Innere Medizin III Ulm, Germany Innere Medizin und Rheumatologie Villingen-Schwenningen, Germany Rheumatologische Praxis Dr. Wörth Wiesbaden, Germany Rheumatologische Schwerpunktpraxis Wuppertal, Germany Med. Klinik und Poliklinik III, Schwerpunkt Rheumatologie Würzburg, Germany Collapse << |
| NCT01749787 | Arthritis, Rheumatoid | Phase 1 | Completed | - | United States, California ... more >> Protalex Investigative Site Los Angeles, California, United States, 90036 United States, Florida Protalex Investigational Site Sarasota, Florida, United States, 34239 United States, Idaho Protalex Investigational Site Coeur d'Alene, Idaho, United States, 83814 United States, Indiana Protalex Investigational Site Anderson, Indiana, United States, 46011 United States, New Mexico Protalex Investigational Site Albuquerque, New Mexico, United States, 87102 United States, North Carolina Protalex Investigational Site Salisbury, North Carolina, United States, 28144 United States, Pennsylvania Protalex Investigational Site Duncansville, Pennsylvania, United States, 16635 United States, Texas Protalex Investigational Site Allen, Texas, United States, 75013 Collapse << |
| NCT00268567 | Nephritis, Lupus | Phase 2 Phase 3 | Completed | - | China ... more >> Renal Division, Peking University First Hospital Beijing, China, 100034 Department of Nephrology, Kidney Center and key Lab of PLA, Chinese General Hospital of PLA Beijing, China Division of Nephrology, Nanfang Hospital, Southern Medical University Guangzhou, China Renal Division, the First Affiliated Hospital, Sun Yat-sen University Guangzhou, China Department of Rheumatology, the Second Affiliated Hospital, Harbin Medical University Harbin, China Department of Nephrology, Shanghai Changzheng Hospital Shanghai, China Renal Division, Huashan Hospital, Fudan University Shanghai, China Renal Division, Renji Hospital, Shanghai Jiaotong University Shanghai, China Collapse << |
| NCT02275299 | Rheumatoid Arthritis | Phase 4 | Unknown | February 2016 | China, Beijing ... more >> Peking Union Medical College Hospital Recruiting Beijing, Beijing, China, 100032 Contact: Fengchun Zhang, doctor +86（10）6915 6114 zhangfccra@yahoo.com.cn Collapse << |
| NCT01620268 | Viruria Virem... more >>ia Collapse << | Phase 2 | Terminated(Lack of recruitment... more >>) Collapse << | - | United States, Alabama ... more >> University of Alabama, Birmingham Birmingham, Alabama, United States, 35294 United States, Florida Tampa General Hospital Tampa, Florida, United States, 33606 United States, Illinois Rush Univeristy Chicago, Illinois, United States, 60612 University of Illinois, Chicago Chicago, Illinois, United States, 60612 The University of Chicago Transplant Center Chicago, Illinois, United States, 60637 United States, Indiana IU Health Indianapolis, Indiana, United States, 46202 United States, Kentucky University of Lousiville Louisville, Kentucky, United States, 40202 United States, Massachusetts Beth Israel Deaconess Hospital Boston, Massachusetts, United States, 02215 United States, Tennessee Methodist University Hospital Memphis, Tennessee, United States, 38104 Collapse << |
| NCT00001863 | Uveitis | Phase 2 | Completed | - | United States, Maryland ... more >> National Eye Institute (NEI) Bethesda, Maryland, United States, 20892 Collapse << |
| NCT00101374 | HIV Infections | Phase 1 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
| NCT00946686 | Rheumatoid Arthritis ... more >> Psoriatic Arthritis Collapse << | Phase 1 | Completed | - | - |
| NCT00003775 | Brain and Central Nervous Syst... more >>em Tumors Collapse << | Phase 2 | Completed | - | - |
| NCT00280644 | Arthritis, Rheumatoid | Phase 4 | Completed | - | Turkey ... more >> Sanofi-Aventis Istanbul, Turkey Collapse << |
| NCT00652665 | To Determine the Bioequivalenc... more >>e Study Under Fasting Collapse << | Phase 1 | Completed | - | - |
| NCT01727193 | Myasthenia Gravis | Phase 3 | Recruiting | January 2020 | China, Guangdong ... more >> the first affiliated hospital,SUN YAT-SEN UNIVERSITY Recruiting GuangZhou, Guangdong, China, 510000 Contact: Liu Wei bin, dean 086-020-887755766 ext 8281 ranliuz@163.com Principal Investigator: Liu Wei bin, dean Collapse << |
| NCT00596206 | Arthritis, Rheumatoid | Phase 3 | Completed | - | Czech Republic ... more >> Sanofi-Aventis Administrative Office Praha, Czech Republic Italy Sanofi-Aventis Administrative Office Milan, Italy Korea, Republic of Sanofi-Aventis Administrative Office Seoul, Korea, Republic of Portugal Sanofi-Aventis Administrative Office Porto Salvo, Portugal Romania Sanofi-Aventis Administrative Office Bucuresti, Romania Collapse << |
| NCT00802243 | Bullous Pemphigoid | Phase 2 | Unknown | - | France ... more >> Limoges University Hospital Recruiting Limoges, France, 87042 Contact: Christophe BEDANE, MD 0555056430 christophe.bedane@chu-limoges.fr Sub-Investigator: Agnès SPARSA, MD Sub-Investigator: Jean Marie BONNETBLANC, MD Sub-Investigator: Julie CENDRAS, MD Bordeaux University Hospital Not yet recruiting Pessac, France, 33604 Contact: Marie Sylvie DOUTRE, MD 0557656432 Principal Investigator: Marie Sylvie DOUTRE, MD Toulouse University Hospital Not yet recruiting Toulouse, France, 31059 Contact: Carle PAUL, MD 0561777675 Principal Investigator: Carle PAUL, MD Collapse << |
| NCT00579878 | Rheumatoid Arthritis | Phase 3 | Completed | - | United States, Nebraska ... more >> University of Nebraska Medical Center Omaha, Nebraska, United States, 69198-3025 Collapse << |
| NCT00834405 | Healthy | Phase 1 | Completed | - | United States, Missouri ... more >> Gateway Medical Research, Inc. St. Charles, Missouri, United States, 63301 United States, Texas Bioassay Laboratory, Inc. Houston, Texas, United States, 77099 Collapse << |
| NCT02981979 | Takayasu Arteritis | Not Applicable | Recruiting | June 2020 | China, Beijing ... more >> Beijing Anzhen Hospital Recruiting Beijing, Beijing, China Contact: Tian Wang China, Jiangxi The first affiliated hospital of Nanchang University Recruiting Nanchang, Jiangxi, China Contact: Rui Wu, Doctor China, Shaanxi Xijing Hospital Recruiting Xi'an, Shaanxi, China Contact: Zhenbiao Wu China, Shanghai Zhongshan hospital, Fudan University Recruiting Shanghai, Shanghai, China, 200032 Contact: Lindi Jiang, Doctor 086-13564223680 jiang.lindi@zs-hospital.edu.cn Contact: Bingjie Wu, Doctor wu.bingjie@zs-hospital.sh.cn Renji Hospital Recruiting Shanghai, Shanghai, China Contact: Liangjing Lv China, Shanxi Shanxi Da Hospital Recruiting Taiyuan, Shanxi, China Contact: Liyun Zhang China, Xinjiang Xinjiang Uygur Autonomous Region People's Hospital Recruiting Urumqi, Xinjiang, China Contact: Lijun Wu Collapse << |
| NCT00834405 | - | - | Completed | - | - |
| NCT00834418 | - | - | Completed | - | - |
| NCT01659242 | Rheumatoid Arthritis | Phase 4 | Terminated | - | Singapore ... more >> Singapore General Hospital Singapore, Singapore, 169608 Collapse << |
| NCT01172002 | Nephritis Lup... more >>us Collapse << | Not Applicable | Unknown | - | China, Shanghai ... more >> RenJi Hospital Recruiting ShangHai, Shanghai, China, 200001 Collapse << |
| NCT00637819 | Systemic Lupus Eythematosus (S... more >>LE) Collapse << | Phase 2 | Completed | - | Hong Kong ... more >> Sanofi-Aventis Hong Kong, Hong Kong Collapse << |
| NCT00653003 | To Determine Bioequivalence Un... more >>der Fed Conditions Collapse << | Phase 1 | Completed | - | - |
| NCT01342016 | Lupus Nephritis | Phase 3 | Terminated(Due to safety conce... more >>rn of active control drug) Collapse << | - | China ... more >> Beijing, China Fujian, China Hubei, China Hunan, China Jiangsu, China Jilin, China Liaoning, China Shandong, China Shanghai, China Shanxi, China Sichuan, China Zhejiang, China Collapse << |
| NCT03599986 | - | - | Recruiting | September 15, 2018 | Egypt ... more >> Adel Mahmoud Elsayed private clinic Recruiting Cairo, Egypt, 1152 Collapse << |
| NCT01611675 | Melanoma | Phase 1 | Terminated(Adverse Events) | - | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Collapse << |
| NCT03715699 | Autoimmune Disease | Not Applicable | Recruiting | December 31, 2020 | China, Beijing ... more >> Yunyun Fei Recruiting Beijing, Beijing, China, 100032 Contact: Yunyun Fei +8613681125226 feiyunyun2013@hotmail.com Collapse << |
| NCT00834418 | Healthy | Phase 1 | Completed | - | United States, North Dakota ... more >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Collapse << |
| NCT03576794 | Polymyalgia Rheumatica | Phase 3 | Not yet recruiting | November 1, 2022 | Netherlands ... more >> ZGT Almelo Not yet recruiting Almelo, Netherlands, 7609 PP Contact: Edgar Colin, MDPhD Contact: Celina Alves, MDPhD University Medical Center Groningen Not yet recruiting Groningen, Netherlands, 9713 GZ Contact: Elisabeth Brouwer, dr +3150 3613432 e.brouwer@umcg.nl Contact: Maria Sandovici, dr +3150 3613432 m.sandovici01@umcg.nl Collapse << |
| NCT02509052 | Recurrent Plasma Cell Myeloma ... more >> Refractory Plasma Cell Myeloma Collapse << | Phase 1 Phase 2 | Active, not recruiting | June 2019 | United States, California ... more >> City of Hope Medical Center Duarte, California, United States, 91010 Collapse << |
| NCT00563849 | Rheumatoid Arthritis | Phase 4 | Completed | - | Korea, Republic of ... more >> Sanofi-Aventis Pusan, Korea, Republic of Collapse << |
| NCT03709446 | Breast Neoplasms ... more >> Breast Diseases Metastatic Triple Negative Breast Cancer Collapse << | Phase 1 Phase 2 | Not yet recruiting | October 20, 2021 | United States, New York ... more >> Icahn School of Medicine at Mount Sinai Not yet recruiting New York, New York, United States, 10029 Contact: Charles Shapiro, MD 212-241-3131 charles.shapiro@mssm.edu Contact: Joni Gomes, BSN 212-824-7076 joni.gomes@mssm.edu Collapse << |
| NCT02703194 | Immunoglobulin G4 Related Scle... more >>rosing Disease Collapse << | Phase 4 | Recruiting | March 2019 | China ... more >> Chinese PLA General Hospital Recruiting Beijing, China, 100000 Contact: Feng Huang 8610-55499114 frankfhuang@126.com Collapse << |
| NCT02024334 | Juvenile Idiopathic Arthritis | Phase 4 | Unknown | December 2014 | Iran, Islamic Republic of ... more >> Recruiting Mashhad, Khorasan Razavi, Iran, Islamic Republic of Contact: Zahra Rezaeiyazdi, MD 00989153115860 Sub-Investigator: malihe bokaiyan, MD Collapse << |
