|瘦素(22-56)|CsnPharm

CAS No.: 183598-56-3

Leptin (22-56), human/瘦素(22-56) Catalog No. CSN21705

Synonyms: LEPTIN(22-56),HUMAN;Leptin (22-56);human

Leptin (22-56) is a biological active fragment of leptin which is a hormone predominantly made by adipose cells and enterocytes that helps to regulate energy balance by inhibiting hunger,

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Leptin is an adipocyte hormone important in appetite, energy homeostasis, neuroendocrine and haematopoietic function ^[1]. Leptin or leptin fragment administration results in a potent inhibition of ACTH and glucocorticoid secretion. Ob-Ra and Ob-Rb subtypes of leptin receptors are expressed in rat adrenocortical cells, and they interact differently in vivo and in vitro with native leptin and leptin fragments. Leptin (22-56), human is a fragment of native leptin which can interact with isoform of Ob-R. Leptin (22-56), human inhibited corticosterone production from rat adrenocortical-cell cultures suggesting that this region of the leptin molecule may be responsible for the direct inhibitory effect on secretion and growth of leptin on cultured rat adreno¬cortical cells ^[2]. Baseline leptin (22-56) levels were higher in haemodialysis (HD) patients vs. controls(7.14 +/- 7.04 ng/ml vs. 1.86 +/- 1.84, P < 0.02). Leptin(22-56) had a significant negative correlation with the erythropoietin to haematocrit ratio (T = -0.42, P < 0.01) suggesting Leptin(22-56) may favour haematopoiesis ^[1].
参考文献

[1] Stamatiadis DN. Elevated leptin fragments in renal failure correlate with BMI and haematopoiesis and are normalized by haemodialysis. Clin Endocrinol (Oxf). 2004 Apr;60(4):434-41.
[2] Malendowicz LK. Effects of leptin and leptin fragments on corticosterone secretion and growth of cultured rat adrenocortical cells. Int J Mol Med. 2004 Nov;14(5):873-7.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.2531 mL
- 1.2657 mL
- 2.5313 mL
- 5 mM
- 0.0506 mL
- 0.2531 mL
- 0.5063 mL
- 10 mM
- 0.0253 mL
- 0.1266 mL
- 0.2531 mL

技术信息

CAS号	183598-56-3	储存条件	粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C171H298N50O56	运输	蓝冰
分子量	3950.50	别名	LEPTIN(22-56),HUMAN;Leptin (22-56);human

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Leptin (22-56), human/瘦素(22-56) Catalog No. CSN21705

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