CAS No.: 87081-35-4
Leptomycin B/来普霉素B Catalog No. CSN20669
Synonyms: CI 940;LMB;Elactocin
Leptomycin B is an inhibitor of the nuclear export of proteins which acts by binding directly to and inhibiting CRM1/exportin-1. Leptomycin B inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53, showing antiviral, antibiotic, antifunal and antitumor in vitro and in vivo.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Sun Q, Carrasco YP, et al. Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1303-8.
- [2] Jang BC, Sung SH, et al. Leptomycin B, a metabolite of Streptomyces, inhibits the expression of inducible nitric oxide synthase in BV2 microglial cells. Int J Oncol. 2006 Dec;29(6):1509-15.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 87081-35-4 | 储存条件 |
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| 分子式 | C33H48O6 | 运输 | 蓝冰 | |
| 分子量 | 540.73 | 别名 | CI 940;LMB;Elactocin;NSC 364372;来普霉素B |
