生物活性

• 描述G1T38 is a potent, selective, and orally bioavailable CDK4/6 inhibitor with unique pharmacokinetic and pharmacodynamic properties, which result in high efficacy against CDK4/6 dependent tumors while minimizing the undesirable on-target bone marrow activity.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03455829	Carcinoma, Non-Small-Cell Lung... more >> Lung Cancer Non-small Cell Lung Cancer Collapse <<	Phase 1 Phase 2	Recruiting	April 2023	United States, California ... more >> Beverly Hills Cancer Center Recruiting Beverly Hills, California, United States, 90211 Principal Investigator: David Berz, MD          St Joseph Heritage Healthcare Recruiting Santa Rosa, California, United States, 95403 Contact: Ian Anderson, MD Collapse <<
  NCT02983071	Carcinoma, Ductal, Breast ... more >> Breast Cancer Breast Neoplasm Collapse <<	Phase 1 Phase 2	Recruiting	December 2020	Bulgaria ... more >> MHAT for Womens Health - Nadezhda OOD Recruiting Sofia, Bulgaria, 1330 Principal Investigator: Boris Krastev, MD          Comac Medical Recruiting Sofia, Bulgaria, 1618 Principal Investigator: Marchela Koleva, MD          Special Hospital For Active Treatment In Oncology Recruiting Sofia, Bulgaria, 1756 Principal Investigator: Galina Kurteva, MD          Georgia ARENSIA Exploratory Medicine LLC Recruiting Tbilisi, Georgia, 0112 Principal Investigator: Marina Maglakelidze, MD          Moldova, Republic of The Institute of Oncology Recruiting Chisinau, Moldova, Republic of, 2025 Principal Investigator: Iurie Bulat, MD          United Kingdom Cambridge University Recruiting Cambridge, United Kingdom, CB2 0QQ Principal Investigator: Richard Baird, MD          University College London Hospital (UCLH) Recruiting London, United Kingdom, NW1 2BU Principal Investigator: Rebecca Roylance, MD          Sarah Cannon Research Institute Recruiting London, United Kingdom, W1G 6AD Principal Investigator: Hendrik-Tobias Arkenau, MD          The Christie NHS Foundation Recruiting Manchester, United Kingdom, M20 4BX Principal Investigator: Andrew Wardley, MD Collapse <<
  NCT02821624	Healthy Volunteers	Phase 1	Completed	-	Netherlands ... more >> PRA Early Development Clinic Groningen, Netherlands Collapse <<