CAS No.: 1151516-14-1
Lesinurad sodium Catalog No. CSN16305
Synonyms: RDEA-594 sodium;Lesinurad;RDEA-594
Lesinurad sodium is an inhibitor of URAT1 and OAT and it is also a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 µM, respectively.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 OAT1
Km:0.85µMOAT3
Km:2µM- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT02028689 Healthy Phase 1 Completed - United States, Michigan ... more >> Kalamazoo, Michigan, United States, 49007 Collapse << - 参考文献
- [1] Dalbeth N, Jones G, et al. Lesinurad, a Selective Uric Acid Reabsorption Inhibitor, in Combination With Febuxostat in Patients With Tophaceous Gout: Findings of a Phase III Clinical Trial. Arthritis Rheumatol. 2017 Jun 9.
- [2] Shen Z, Yeh LT, et al. In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters. Clin Drug Investig. 2016 Jun;36(6):443-52.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1151516-14-1 | 储存条件 |
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| 分子式 | C17H13BrN3NaO2S | 运输 | 蓝冰 | |||
| 分子量 | 426.26 | 别名 | RDEA-594 sodium;Lesinurad;RDEA-594;brand name: Zurampic | |||
| 溶解度 |
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动物实验配方 |
