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CAS No.: 30508-27-1

Licoricidin/甘草西定 Catalog No. CSN14313

Synonyms: 甘草西定

Licoricidin, a natural product isolated and purified from the roots of Glycyrrhiza uralensis., inhibits lung metastasis of 4T1 mammary carcinoma cells, which may be mediated via inhibition of cancer cell migration, tumor angiogenesis, and lymphangiogenesis., and also blocks UVA-induced photoaging via ROS scavenging,this activity converges to limit the activity of MMP-1, suggests that licoricidin may be considered as an active ingredient in topically applied anti-ageing formulations.

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描述Licoricidin, a natural product isolated and purified from the roots of Glycyrrhiza uralensis., inhibits lung metastasis of 4T1 mammary carcinoma cells, which may be mediated via inhibition of cancer cell migration, tumor angiogenesis, and lymphangiogenesis., and also blocks UVA-induced photoaging via ROS scavenging,this activity converges to limit the activity of MMP-1, suggests that licoricidin may be considered as an active ingredient in topically applied anti-ageing formulations. Licoricidin is also effective in inhibiting the growth of all three bacterial species (Porphyromonas gingivalis, Prevotella intermedia and Solobacterium moorei), with minimal inhibitory concentrations in the range of 2-80 ug /mL. They have a potential for reducing bacterial volatile sulfur compounds (VSCs) production and therefore for controlling halitosis, and has potential for the development of host-modulating strategies for the treatment of cytokine and/or MMP-mediated disorders such as periodontitis.
参考文献

[1] Park SY, Kwon SJ, et al. Licoricidin, an Active Compound in the Hexane/Ethanol Extract of Glycyrrhiza uralensis, Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells. Int J Mol Sci. 2016 Jun 14;17(6). pii: E934.
[2] Park SY, Lim SS, et al. Hexane-ethanol extract of Glycyrrhiza uralensis containing licoricidin inhibits the metastatic capacity of DU145 human prostate cancer cells. Br J Nutr. 2010 Nov;104(9):1272-82.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3555 mL
- 11.7777 mL
- 23.5555 mL
- 5 mM
- 0.4711 mL
- 2.3555 mL
- 4.7111 mL
- 10 mM
- 0.2356 mL
- 1.1778 mL
- 2.3555 mL

技术信息

CAS号	30508-27-1	储存条件	粉末液体 -20°C:3-6 月 -80°C:12月
分子式	C26H32O5	运输	蓝冰
分子量	424.53	别名	甘草西定

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