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CAS No.: 859-18-7

Lincomycin HCl/盐酸林可霉素 Catalog No. CSN11303

Synonyms: U10149A;NSC 70731;Antibiotic 124a HCl

Lincomycin HCl is a lincosamide antibiotic that comes from the actinomycete Streptomyces lincolnensis, used to treat severe bacterial infections in people who cannot use penicillin antibiotics.

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描述Lincomycin hydrochloride capsules, a conventional antibiotic indicates effective treatment for relief from tonsillitis and sinusitis, as compared to new third generation antibiotic^[3]. Relative to clindamycin, lincomycin hydrochloride had longer onset of peak values and lower overall concentration in ocular tissues. Intravitreous injection of lincomycin hydrochloride produced therapeutic and steady levels of antibiotic in anterior chambers. Injection produced a concentration in aqueous humor twice that achievable topically^[4]. Lincomycin hydrochloride inhibits cell growth and microbial protein synthesis, by interacting strongly and specifically with the 50S ribosomal subunit, at mutually related sites^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01876628	Cellulitis	Phase 4	Unknown	January 2016	United Kingdom ... more >> University Hospitals Bristol NHS Foundation Trust Bristol, United Kingdom, BS2 8HW Collapse <<
NCT02099240	Osteomyelitis	Early Phase 1	Recruiting	September 2019	United States, Kentucky ... more >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu Sub-Investigator: Forest Arnold, DO Sub-Investigator: Timothy Wiemkwn, PhD Sub-Investigator: Robert Kelley, PhD Sub-Investigator: James Summersgill, PhD Sub-Investigator: Ruth Carrico, PhD Sub-Investigator: Julie Harting, PharmD Sub-Investigator: Paula Peyrani, MD Principal Investigator: David Seligson, MD Sub-Investigator: Craig Roberts, MD Principal Investigator: Julio Ramirez, MD Collapse <<
NCT01058824	Bacterial Infections	Phase 1	Completed	-	Brazil ... more >> Pfizer Investigational Site Campinas, Sao Paulo, Brazil, 13012-000 Pfizer Investigational Site Campinas, Sao Paulo, Brazil, 13012-431 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2573 mL
- 11.2867 mL
- 22.5735 mL
- 5 mM
- 0.4515 mL
- 2.2573 mL
- 4.5147 mL
- 10 mM
- 0.2257 mL
- 1.1287 mL
- 2.2573 mL

技术信息

CAS号

859-18-7

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H35ClN2O6S

运输

蓝冰

分子量

443.00

别名

U10149A;NSC 70731;Antibiotic 124a HCl;Lincomycin HCl;Mycivin;盐酸林可霉素

溶解度

DMSO	89.0 mg/mL (200.9 mM)
Water	88.0 mg/mL (198.6 mM)
Ethanol	Insoluble

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01876628	Cellulitis	Phase 4	Unknown	January 2016	United Kingdom ... more >> University Hospitals Bristol NHS Foundation Trust Bristol, United Kingdom, BS2 8HW Collapse <<
NCT02099240	Osteomyelitis	Early Phase 1	Recruiting	September 2019	United States, Kentucky ... more >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu Sub-Investigator: Forest Arnold, DO Sub-Investigator: Timothy Wiemkwn, PhD Sub-Investigator: Robert Kelley, PhD Sub-Investigator: James Summersgill, PhD Sub-Investigator: Ruth Carrico, PhD Sub-Investigator: Julie Harting, PharmD Sub-Investigator: Paula Peyrani, MD Principal Investigator: David Seligson, MD Sub-Investigator: Craig Roberts, MD Principal Investigator: Julio Ramirez, MD Collapse <<
NCT01058824	Bacterial Infections	Phase 1	Completed	-	Brazil ... more >> Pfizer Investigational Site Campinas, Sao Paulo, Brazil, 13012-000 Pfizer Investigational Site Campinas, Sao Paulo, Brazil, 13012-431 Collapse <<
NCT01876628	Cellulitis	Phase 4	Unknown	January 2016	United Kingdom ... more >> University Hospitals Bristol NHS Foundation Trust Bristol, United Kingdom, BS2 8HW Collapse <<
NCT02099240	Osteomyelitis	Early Phase 1	Recruiting	September 2019	United States, Kentucky ... more >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu Sub-Investigator: Forest Arnold, DO Sub-Investigator: Timothy Wiemkwn, PhD Sub-Investigator: Robert Kelley, PhD Sub-Investigator: James Summersgill, PhD Sub-Investigator: Ruth Carrico, PhD Sub-Investigator: Julie Harting, PharmD Sub-Investigator: Paula Peyrani, MD Principal Investigator: David Seligson, MD Sub-Investigator: Craig Roberts, MD Principal Investigator: Julio Ramirez, MD Collapse <<
NCT01058824	Bacterial Infections	Phase 1	Completed	-	Brazil ... more >> Pfizer Investigational Site Campinas, Sao Paulo, Brazil, 13012-000 Pfizer Investigational Site Campinas, Sao Paulo, Brazil, 13012-431 Collapse <<

Lincomycin HCl/盐酸林可霉素 Catalog No. CSN11303

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