|(2S,4R)-N-((1R,2R)-2-羟基-1-((2R,3R,4S,5R,6R)-3,4,5-三羟基-6-(甲硫基)四氢-2H-吡喃-2-基)丙基)-1-甲基-4-丙基吡咯烷-2-甲酰胺盐酸盐水合物|CsnPharm

CAS No.: 7179-49-9

Lincomycin HCl Monohydrate/盐酸林可霉素一水合物 Catalog No. CSN11304

Synonyms: Lincocin;Lincomix;Lincomycin HCl

Lincomycin HCl is a narrow-spectrum antibiotic, has similar effects to erythromycin, which has a good effect on Gram-positive coccus, mainly used to inhibit the synthesis of bacterial cell protein.

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描述Lincomycin HCl H2O is a lincosamide antibiotics used in clinical practice. It is bacteriostatic and inhibit protein synthesis in sensitive bacteria. It may even be bactericidal at the higher concentrations that can be reached in vivo^[2]. Lincomycin and its derivatives are antibiotics exhibiting biological activity against Gram-positive bacteria. The semi-synthetic chlorinated lincomycin derivative is used in clinical practice^[3]. Peak plasma level of lincomycin (71.8 ± 1.83 μg/mL) was observed at 1 min as expected by IV route. The elimination half-life and MRT of lincomycin were short (3.30 ± 0.08 and 4.32 ± 0.11 h, respectively). Lincomycin 10 mg/kg IV at 12-h interval would be sufficient to maintain T > MIC above 60 % for bacteria with minimum inhibitory concentrations (MIC) values ≤1.6 μg/mL. Lincomycin may be an appropriate antibacterial in buffalo species for gram-positive and anaerobic bacterial pathogens susceptible to lincomycin^[4]. The place of lincomycin in therapeutics seems to be principally in the treatment of chronic osteomyelitis and, in patients allergic to the penicillins, in the treatment of staphylococcal, respiratory and other infections for which penicillin is usually employed^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1691 mL
- 10.8457 mL
- 21.6913 mL
- 5 mM
- 0.4338 mL
- 2.1691 mL
- 4.3383 mL
- 10 mM
- 0.2169 mL
- 1.0846 mL
- 2.1691 mL

技术信息

CAS号

7179-49-9

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H37ClN2O7S

运输

蓝冰

分子量

461.01

别名

Lincocin;Lincomix;Lincomycin HCl;NSC- 70731;林可霉素

溶解度

DMSO	92.0 mg/mL (199.6 mM)

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Lincomycin HCl Monohydrate/盐酸林可霉素 一水合物 Catalog No. CSN11304

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Lincomycin HCl Monohydrate/盐酸林可霉素一水合物 Catalog No. CSN11304