CAS No.: 76547-98-3
Lisinopril/赖诺普利 Catalog No. CSN11313
Synonyms: MK-521;MK-522;Prinivil
Lisinopril is angiotensin-converting enzyme inhibitor that blocks the formation of angiotensin I with an IC50 value of 1.2 nM (ovine) and displays ID50 values of 2.3 and 6.5 µg/kg in rat and canine, respectively. It is used in treatment of hypertension, congestive heart failure, and heart attacks.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00567307 Cardiovascular Disease Phase 2 Completed - Sri Lanka ... more >> The National Hospital of Sri Lanka Colombo, Sri Lanka, Colombo10 Teaching (General) Hospital Kandy Kandy, Sri Lanka Teaching (General) Hospital Kegalle Kegalle, Sri Lanka Collapse << NCT00292162 Chronic Heart Failure ... more >> Atrial Fibrillation Collapse << Not Applicable Completed - United Kingdom ... more >> Glasgow Royal Infirmary Glasgow, Scotland, United Kingdom, G31 2ER Collapse << NCT03461003 Pediatric Hypertension Phase 4 Recruiting January 2020 United States, Texas ... more >> The University of Texas Health Science Center at Houston Recruiting Houston, Texas, United States, 77030 Contact: Joyce P Samuel, MD, MS 713-500-5670 joyce.p.samuel@uth.tmc.edu Collapse << - 更多
- 参考文献
- [1] Andujar-Sanchez, M., V. Jara-Perez, and A. Camara-Artigas, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett, 2007. 581(18): p. 3449-54.
- [2] Gomez HJ, Cirillo VJ, Moncloa F. The clinical pharmacology of lisinopril. J Cardiovasc Pharmacol. 1987;9 Suppl 3:S27-34.
- [3] Song JC. Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet. 2002;41(3):207-24. doi: 10.2165/00003088-200241030-00005.
- [4] Swaan PW. Molecular mechanism for the relative binding affinity to the intestinal peptide carrier. Comparison of three ACE-inhibitors: enalapril, enalaprilat, and lisinopril. Biochim Biophys Acta. 1995 May 24;1236(1):31-8. doi: 10.1016/0005-2736(95)00030-7.
- [5] Nemoto S. Differential effects of the angiotensin-converting enzyme inhibitor lisinopril versus the beta-adrenergic receptor blocker atenolol on hemodynamics and left ventricular contractile function in experimental mitral regurgitation. J Am Coll Cardiol. 2002 Jul 3;40(1):149-54. doi: 10.1016/s0735-1097(02)01926-5.
- [6] Mantle D. Effects of lisinopril and amlodipine on antioxidant status in experimental hypertension. Clin Chim Acta. 2000 Sep;299(1-2):1-10. doi: 10.1016/s0009-8981(00)00270-9.
- [7] Mohammadi-Karakani A, Ghazi-Khansari M, Sotoudeh M. Lisinopril ameliorates paraquat-induced lung fibrosis. Clin Chim Acta. 2006 May;367(1-2):170-4. doi: 10.1016/j.cca.2005.12.012. Epub 2006 Feb 3.
- [8] Selim Isbir C. The protective effect of lisinopril on membrane-bound enzymes in myocardial preservation. Cell Biochem Funct. 2000 Jun;18(2):85-91.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 76547-98-3 | 储存条件 |
|
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| 分子式 | C21H31N3O5 | 运输 | 蓝冰 | |
| 分子量 | 405.49 | 别名 | MK-521;MK-522;Prinivil;Zestril;Linopril;Lisipril;Lysinopril;Lysinopril MK-521;赖诺普利 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT00567307 | Cardiovascular Disease | Phase 2 | Completed | - | Sri Lanka ... more >> The National Hospital of Sri Lanka Colombo, Sri Lanka, Colombo10 Teaching (General) Hospital Kandy Kandy, Sri Lanka Teaching (General) Hospital Kegalle Kegalle, Sri Lanka Collapse << |
| NCT00292162 | Chronic Heart Failure ... more >> Atrial Fibrillation Collapse << | Not Applicable | Completed | - | United Kingdom ... more >> Glasgow Royal Infirmary Glasgow, Scotland, United Kingdom, G31 2ER Collapse << |
| NCT03461003 | Pediatric Hypertension | Phase 4 | Recruiting | January 2020 | United States, Texas ... more >> The University of Texas Health Science Center at Houston Recruiting Houston, Texas, United States, 77030 Contact: Joyce P Samuel, MD, MS 713-500-5670 joyce.p.samuel@uth.tmc.edu Collapse << |
| NCT00123903 | Heart Failure, Congestive and ... more >>Microalbuminuria Collapse << | Phase 3 | Terminated | - | - |
| NCT01774656 | Heart Failure NYHA Class III ... more >> Heart Failure NYHA Class IV Collapse << | Phase 4 | Recruiting | December 2017 | United States, Kentucky ... more >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Terry Blanton, BSN, RN mtblan02@louisville.edu Principal Investigator: Emma Birks, MD, PhD United States, Nebraska University of Nebraska Medical Center Recruiting Omaha, Nebraska, United States, 68198 Contact: Stacy Flickbohm, RN 402-559-5127 stacy.fickbohm@unmc.edu Contact: Natalie Kamtz 402-559-3293 natalie.kamtz@unmc.edu Principal Investigator: Brian D Lowes, MD, PhD United States, New York Montefiore Medical Center Recruiting New York, New York, United States, 10467 Contact: Auris Brown aubrowne@montefiore.org Contact: Johanna Oviedo 718-920-8780 joviedo@montefiore.org Principal Investigator: Snehal Patel, MD United States, Ohio Cleveland Clinic Recruiting Cleveland, Ohio, United States, 44195 Contact: Barb Gus, RN BSN CCRC 216-445-6552 GUSB@ccf.org Principal Investigator: Maria Mountis, D.O. United States, Pennsylvania University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19140 Contact: Judith Marble Judith.Marble@uphs.upenn.edu Principal Investigator: J E Rame, MD United States, Utah University of Utah Recruiting Salt Lake City, Utah, United States, 84112 Contact: Ashley Elmer ashley.elmer@hsc.utah.edu Principal Investigator: Craig Selzman, MD Collapse << |
| NCT02774460 | Hypertension | Phase 4 | Not yet recruiting | November 2020 | Sweden ... more >> Uppsala University hospital, Internal medicine research, Oscar II Not yet recruiting Uppsala, Sweden, SE-752 37 Contact: Kerstin Marttala, Study nurse 004618-6113632 kerstin.marttala@akademiska.se Principal Investigator: Johan Sundstrom, Professor Collapse << |
| NCT01901549 | Acute Coronary Syndrome ... more >> Arterial Hypertension Collapse << | Phase 2 | Unknown | June 2016 | Russian Federation ... more >> State Research Institute of Circulation Pathology Recruiting Novosibirsk, Russian Federation, 630055 Contact: Evgeny Pokushalov, MD, PhD +79139254858 E.Pokushalov@gmail.com Principal Investigator: Evgeny Pokushalov, MD, PhD Sub-Investigator: Alexander Romanov, MD Sub-Investigator: Alexander Osiev, MD PhD Sub-Investigator: Igor Grazhdankin, MD Collapse << |
| NCT01575652 | Disorders Associated With Peri... more >>toneal Dialysis Collapse << | Phase 4 | Completed | - | - |
| NCT00567307 | - | - | Completed | - | - |
| NCT02232880 | Hypertension | Phase 2 | Terminated(failure to recruit) | - | United States, Tennessee ... more >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232-6602 Collapse << |
| NCT02232880 | - | - | Terminated(failure to recruit) | - | - |
| NCT00292162 | - | - | Completed | - | - |
| NCT00605072 | - | - | Completed | - | - |
| NCT00283686 | - | - | Completed | - | - |
| NCT00605072 | Cognitive Impairment ... more >> Hypertension Aging Collapse << | Phase 2 | Completed | - | United States, California ... more >> University of Southern California Los Angeles, California, United States, 90033 United States, Massachusetts Hebrew SeniorLife Boston, Massachusetts, United States, 02131 Collapse << |
| NCT00994253 | Hypertension ... more >>Diabetes Type 2 Collapse << | Phase 4 | Withdrawn(Due to safety concer... more >>ns re the concomitant use of aliskiren with an ACEi or ARB.) Collapse << | December 2012 | United States, Michigan ... more >> William Beaumont Hospital Royal Oak, Michigan, United States, 48073 Collapse << |
| NCT00283686 | Kidney, Polycystic | Phase 3 | Completed | - | United States, Colorado ... more >> University of Colorado Health Sciences Center Denver (Aurora), Colorado, United States, 800045 United States, Georgia Emory University School of Medicine Atlanta, Georgia, United States, 30322 United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States, 66160 United States, Massachusetts Tufts University-New England Medical Center Boston, Massachusetts, United States, 02111 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 Collapse << |
| NCT00171535 | Hypertension | Phase 3 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States, 07936 Collapse << |
| NCT00555217 | Kidney Disease ... more >> Nephropathy Type 2 Diabetes Collapse << | Phase 3 | Terminated(It was stopped prim... more >>arily because of safety concerns along with low conditional power to detect a treatment effect on the primary outcome.) Collapse << | - | - |
| NCT02412761 | Essential Hypertension | Not Applicable | Completed | - | United States, Texas ... more >> University of Texas at Houston Medical School; Pediatric Nephrology and Hypertension Clinics Houston, Texas, United States, 77030 Collapse << |
| NCT01837069 | Osteoarthritis ... more >> Cardiovascular Disease Collapse << | Phase 4 | Suspended(Low recruitment / DS... more >>MB approval to halt recruitment) Collapse << | December 2018 | United States, New York ... more >> NYU Hospital for Joint Diseases New York, New York, United States, 10003 Collapse << |
| NCT00555217 | - | - | Terminated(It was stopped prim... more >>arily because of safety concerns along with low conditional power to detect a treatment effect on the primary outcome.) Collapse << | - | - |
| NCT01437371 | Heart Failure | Phase 3 | Completed | - | France ... more >> CHU Clermont-Ferrand Clermont-Ferrand, France, 63003 Collapse << |
| NCT02412761 | - | - | Completed | - | - |
| NCT00006294 | - | - | Completed | - | United States, Kentucky ... more >> University of Kentucky Lexington, Kentucky, United States, 40536 Collapse << |
| NCT01313702 | Cardiovascular Disease | Phase 3 | Unknown | July 2014 | Brazil ... more >> Instituto de Ensino e Pesquisa - IEP - HCor Not yet recruiting Sao Paulo, Brazil, 04005-000 Contact: Otavio Berwanger, PhD +55 11 30536611 ext 8203 oberwanger@hcor.com.br Principal Investigator: Otavio Berwanger, PhD Collapse << |
| NCT02847338 | Hypertension | Phase 4 | Recruiting | November 2021 | United Kingdom ... more >> Cambridge University Hospitals NHS Foundation Trust Recruiting Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ Contact: Ella James 01223 349762 Principal Investigator: Joseph Cheriyan Queen Elizabeth Hospital Recruiting Birmingham, United Kingdom, B15 2TH Principal Investigator: Una Martin Sandwell & West Birmingham Hospitals NHS Trust Recruiting Birmingham, United Kingdom, B18 7QH Contact: Ronnie HAYNES 0121 507 5113 ronnie.haynes@nhs.net Contact: Rebecca Brown 0121 507 6657 Rebecca.brown15@nhs.net Principal Investigator: Gregory Lip University Hospital Llandough Recruiting Cardiff, United Kingdom, CF64 2XX Contact: Maggie Munnery 029 20416278 MMunnery@cardiffmet.ac.uk Contact: Barry McDonnell 029 206827 bmcdonnell@cardiffmet.ac.uk Principal Investigator: James Coulson University of Glasgow Recruiting Glasgow, United Kingdom, G12 8TA Principal Investigator: Sandosh Padmanabhan Leicester General Hospital Not yet recruiting Leicester, United Kingdom, LE5 4PW Principal Investigator: Kamlesh Khunti William Harvey Research Institute, Barts and the London Medical School Recruiting London, United Kingdom, EC1M 6BQ Principal Investigator: David Collier St. Thomas Hospital Recruiting London, United Kingdom, SE1 7EH Principal Investigator: Phil Chowienczyk Sub-Investigator: Luca Faconti Imperial College Healthcare NHS Trust St. Marys Hospital Not yet recruiting London, United Kingdom, W2 1NY Principal Investigator: Simon Thom University College London Not yet recruiting London, United Kingdom, WC1E 7HB Principal Investigator: Alun Hughes Manchester Royal Infirmary Recruiting Manchester, United Kingdom, M13 9WL Principal Investigator: Tony Heagerty Newcastle Hospital NHS Foundation Trust Not yet recruiting Newcastle, United Kingdom, NE2 4HH Principal Investigator: Simon Thomas Collapse << |
| NCT00874432 | Cardiovascular Disease ... more >> Chronic Kidney Disease Collapse << | Not Applicable | Completed | - | United States, Wisconsin ... more >> University of Wisconsin-Madison Hospitals and Clinics Madison, Wisconsin, United States, 53792 Collapse << |
| NCT00151138 | Hypertension | Not Applicable | Completed | - | United States, Pennsylvania ... more >> Dept of Psychiatry, University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 Collapse << |
| NCT00814255 | - | - | Completed | - | - |
| NCT02603809 | Essential Hypertension | Phase 2 | Completed | - | - |
| NCT02641899 | Healthy | Phase 1 | Completed | - | United States, Kansas ... more >> Quintiles Overland Park, Kansas, United States, 66211 Collapse << |
| NCT00814255 | Focal Segmental Glomeruloscler... more >>osis Collapse << | Phase 2 | Completed | - | United States, Florida ... more >> University of Miami Miami, Florida, United States, 33136 United States, Georgia Emory University Atlanta, Georgia, United States, 30322 United States, Kansas University of Kansas Kansas City, Kansas, United States, 66160 United States, Massachusetts Boston Children's Hospital Boston, Massachusetts, United States, 02115 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48109 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55901 United States, Missouri Children's Mercy Hospital Kansas City, Missouri, United States, 64108 Cardinal Glennon Children's Medical Center Saint Louis, Missouri, United States, 63104 United States, New York Steven and Alexandra Cohen Children's Medical Center of New York New Hyde Park, New York, United States, 11040 NYU Langone Medical Center New York, New York, United States, 10016 Columbia University Medical Center New York, New York, United States, 10032 United States, North Carolina Carolinas Medical Center Charlotte, North Carolina, United States, 28207 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229 Ohio State University Columbus, Ohio, United States, 43205 United States, Oregon Doernbecher Children's Hospital Portland, Oregon, United States, 97239 United States, South Carolina Medical University of South Carolina Charleston, South Carolina, United States, 29425 United States, Texas Texas Tech University El Paso, Texas, United States, 79905 Canada, Alberta University of Alberta Edmonton, Alberta, Canada, T6G 2R7 Collapse << |
| NCT03195023 | Renal Insufficiency, Chronic ... more >> Proteinuria Collapse << | Phase 4 | Recruiting | June 2021 | Spain ... more >> Gregorio Maranon Hospital Recruiting Madrid, Spain, 28007 Contact: Maria Angeles Goicoechea, PhD, MD 0034609838684 marian.goicoechea@gmail.com Contact: Ana María García, MD 0034676611045 anamgarciaprieto@gmail.com Collapse << |
| NCT01535235 | HIV | Phase 4 | Completed | - | United States, California ... more >> San Francisco General Hospital San Francisco, California, United States, 94110 Collapse << |
| NCT01535235 | - | - | Completed | - | - |
| NCT00280215 | Hyperoxaluria | Phase 3 | Withdrawn(Inadequate number of... more >> patients, lack of funding) Collapse << | - | - |
| NCT03422705 | Pacemakers, Heart Failure | Phase 2 | Not yet recruiting | September 1, 2021 | - |
| NCT01885559 | Kidney, Polycystic | Phase 3 | Completed | - | United States, Colorado ... more >> University of Colorado Health Sciences Center Denver (Aurora), Colorado, United States, 800045 United States, Georgia Emory University School of Medicine Atlanta, Georgia, United States, 30322 United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States, 66160 United States, Massachusetts Tufts University-New England Medical Center Boston, Massachusetts, United States, 02111 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 Collapse << |
| NCT00219167 | Hypertension | Phase 3 | Completed | - | Switzerland ... more >> Novartis Pharmaceuticals Basel, Switzerland Collapse << |
| NCT02358642 | Pneumonia Neu... more >>rological Dysphagia Collapse << | Phase 4 | Terminated(The interim analysi... more >>s suggested that low dose lisinopril given to be tube fed older patients with neuroligical dysphagia had increased mortality.) Collapse << | - | Hong Kong ... more >> Prince of Wales Hospital Hong Kong, Hong Kong Collapse << |
| NCT00004266 | Diabetic Nephropathy | Phase 3 | Completed | - | United States, Minnesota ... more >> Hennepin County Medical Center Minneapolis, Minnesota, United States, 55415 Collapse << |
| NCT00982189 | HIV Infection ... more >> Cardiovascular Disease Risk Collapse << | Not Applicable | Completed | - | United States, Minnesota ... more >> Hennepin County Medical Center Minneapolis, Minnesota, United States, 55415 Collapse << |
| NCT01506505 | Cardiovascular Disease ... more >> Cerebrovascular Disease Peripheral Arterial Disease Collapse << | Not Applicable | Completed | - | Netherlands ... more >> UMC Utrecht Utrecht, Netherlands, 3508 GA Collapse << |
| NCT01885559 | - | - | Completed | - | - |
| NCT00118976 | Diabetes Mellitus, Type I ... more >> Diabetic Nephropathy Collapse << | Not Applicable | Completed | - | Denmark ... more >> Steno Diabetes Center Gentofte, Denmark, 2820 Collapse << |
| NCT03201939 | HIV/AIDS Albu... more >>minuria Kidney Diseases Genetic Predisposition Collapse << | Phase 2 | Recruiting | August 31, 2022 | Nigeria ... more >> Aminu Kano Teaching Hospital Recruiting Kano, Nigeria Contact: Baba M Musa, MBBS, MPH +234-803-347-2311 babamaiyaki2000@yahoo.co.uk Contact: Faisal S. Danikshiya, MBBS 234-806-129-7871 fdankishiya@yahoo.com Collapse << |
| NCT00982189 | - | - | Completed | - | - |
| NCT00837590 | Pre-diabetes ... more >>Obesity Collapse << | Not Applicable | Completed | - | United States, Indiana ... more >> Indiana Clinical Research Center Indianapolis, Indiana, United States, 46202 Collapse << |
| NCT00657241 | Hypertension | Phase 3 | Completed | - | United States, New York ... more >> Erie County Medical Center Buffalo, New York, United States, 14215 Collapse << |
| NCT01518166 | Diabetes Heal... more >>thy Collapse << | Phase 1 | Completed | - | Sweden ... more >> Novo Nordisk Investigational Site Uppsala, Sweden, 75323 Collapse << |
| NCT00108082 | Hypertrophy, Left Ventricular | Phase 3 | Completed | - | - |
| NCT02441842 | Perioperative Hypertension | Phase 4 | Completed | - | - |
| NCT02682459 | Extracapillary Glomerulonephri... more >>tis Collapse << | Phase 2 | Recruiting | December 2019 | Italy ... more >> Centro di Ricerche Cliniche per le Malattie Rare Aldo e Cele Daccò Recruiting Ranica, Bergamo, Italy, 24020 Sub-Investigator: Barbara Ruggiero, MD ASST Papa Giovanni XXIII Recruiting Bergamo, Italy, 24147 Principal Investigator: Giuseppe Remuzzi, MD Sub-Investigator: Ettore Sabadini, MD Sub-Investigator: Piero Ruggenenti, MD Collapse << |
| NCT00108082 | - | - | Completed | - | - |
| NCT00582114 | Hemodialysis ... more >>Hypertension Left Ventricular Hypertrophy Collapse << | Phase 3 | Terminated(Stopped by data saf... more >>ety monitoring board) Collapse << | - | United States, Indiana ... more >> Indiana University Indianapolis, Indiana, United States, 46202 Collapse << |
| NCT00537043 | Hypertension | Phase 1 | Completed | - | United States, New Jersey ... more >> GSK Investigational Site Hackensack, New Jersey, United States, 07601 United States, Texas GSK Investigational Site Austin, Texas, United States, 78704 Collapse << |
| NCT00582114 | - | - | Terminated(Stopped by data saf... more >>ety monitoring board) Collapse << | - | - |
| NCT01234922 | - | - | Terminated(slow accrual) | - | - |
| NCT02336607 | Hypertension | Not Applicable | Completed | - | - |
| NCT01234922 | Hypertension ... more >>Unspecified Adult Solid Tumor, Protocol Specific Collapse << | Phase 2 | Terminated(slow accrual) | - | United States, North Carolina ... more >> Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 Collapse << |
| NCT00311870 | Diabetic Nephropathy | Phase 4 | Completed | - | Denmark ... more >> Steno Diabetes Center Gentofte, Denmark, DK-2820 Collapse << |
| NCT00219050 | Hypertension | Phase 3 | Completed | - | Germany ... more >> Investigative Site Berlin, Germany Hungary Investigative Site Budapest, Hungary Spain Investigative Site Madrid, Spain Switzerland Novartis Pharmaceuticals Basel, Switzerland Collapse << |
| NCT00773084 | Diastolic Heart Failure | Not Applicable | Withdrawn(Difficulty in recrui... more >>ting patients and then the PI left the institution) Collapse << | August 2009 | United States, Texas ... more >> Texas Tech University Health Sciences Center Lubbock, Texas, United States, 79430 Collapse << |
| NCT00430040 | Diabetes Mellitus, Type 2 ... more >> Hypertension Collapse << | Phase 4 | Unknown | May 2013 | United States, New York ... more >> Diabetes - Endocrinology Center of Western New York Buffalo, New York, United States, 14221 Collapse << |
| NCT02336607 | - | - | Completed | - | - |
| NCT01181284 | - | - | Completed | - | United States, Minnesota ... more >> Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse << |
| NCT01691781 | - | - | Completed | - | - |
| NCT01009944 | Hypertension | Not Applicable | Active, not recruiting | March 2018 | United States, Massachusetts ... more >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Collapse << |
| NCT00556920 | Hypertension | Phase 1 | Completed | - | United States, New York ... more >> GSK Investigational Site Buffalo, New York, United States, 14202 Collapse << |
| NCT01691781 | Hyperparathyroidism | Not Applicable | Completed | - | United States, Massachusetts ... more >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Collapse << |
| NCT02369926 | Multiple Sclerosis, Relapsing-... more >>Remitting Collapse << | Phase 2 | Recruiting | - | United States, New York ... more >> Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029 Contact: Tarah Gustafson tarah.gustafson@mssm.edu Principal Investigator: Fred Lublin, MD Collapse << |
| NCT00241124 | Hypertension | Phase 4 | Completed | - | Germany ... more >> Investigative Centers, Germany Collapse << |
| NCT01324388 | Diabetes Mellitus, Type 2 | Phase 1 | Completed | - | United States, Hawaii ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Honolulu, Hawaii, United States, 96813 United States, Indiana For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Evansville, Indiana, United States, 47710 United States, Texas For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Dallas, Texas, United States, 75247 Collapse << |
| NCT00337298 | Type 1 Diabetes ... more >> Diabetic Retinopathy Eye Diseases Diabetes Complications Collapse << | Not Applicable | Completed | - | Denmark ... more >> Aarhus university hospital Aarhus, Denmark, 8000 Collapse << |
| NCT00171574 | Hypertension ... more >>Diabetic Nephropathy Collapse << | Phase 4 | Completed | - | Switzerland ... more >> Novartis Pharmaceuticals Basel, Switzerland Collapse << |
| NCT01324388 | - | - | Completed | - | - |
| NCT00549510 | Hypertension | Phase 1 | Completed | - | United States, Texas ... more >> GSK Investigational Site Austin, Texas, United States, 78744 Collapse << |
| NCT00557128 | Hypertension | Phase 1 | Completed | - | United States, Texas ... more >> GSK Investigational Site Austin, Texas, United States, 78744 Collapse << |
| NCT00553969 | - | - | Completed | - | - |
| NCT00553969 | Pre-hypertension | Phase 1 Phase 2 | Completed | - | United States, Minnesota ... more >> University of Minnesota, Variety Club Research Center 102 Minneapolis, Minnesota, United States, 55455 Collapse << |
| NCT02623036 | Hypertension, Resistant to Con... more >>ventional Therapy Collapse << | Phase 1 | Recruiting | April 2018 | United States, Georgia ... more >> Memorial Family Medicine Center Recruiting Savannah, Georgia, United States, 31404 Contact: John Bucheit, Pharm.D. 312-350-8404 bucheit_jd@mercer.edu Principal Investigator: John Bucheit, Pharm.D. Sub-Investigator: Cindy Gleit, M.D. Sub-Investigator: Kathryn Momary, Pharm.D. Sub-Investigator: Angela Kaylor, R.N. Sub-Investigator: Daniel Gordon, M.D. Collapse << |
| NCT01398267 | Diabetes Mellitus Type 2 | Phase 1 | Completed | - | United States, California ... more >> Chula Vista, California, United States, 91911 United States, Nebraska Omaha, Nebraska, United States, 68154 United States, Texas Dallas, Texas, United States, 75247 San Antonio, Texas, United States, 78209 Collapse << |
| NCT01101269 | Type 2 Diabetes | Not Applicable | Terminated(Slow Recruitment) | - | United States, Virginia ... more >> University of Virginia Health System Charlottesville, Virginia, United States, 22908 Collapse << |
| NCT00734630 | Hypertension | Phase 4 | Completed | - | - |
| NCT01218100 | - | - | Completed | - | - |
| NCT00171600 | Hypertension ... more >>Early Diabetic Nephropathy Collapse << | Phase 4 | Terminated | - | Switzerland ... more >> Novartis Pharmaceuticals Basel, Switzerland Collapse << |
| NCT01218100 | Stage 2 Diastolic Hypertension | Phase 4 | Completed | - | - |
| NCT00883506 | Hypertension | Phase 1 | Completed | - | - |
| NCT00171067 | Hypertension | Phase 3 | Completed | - | Germany ... more >> Investigative Centers, Germany Switzerland Novartis Pharmaceuticals Basel, Switzerland Collapse << |
| NCT00734630 | - | - | Completed | - | - |
| NCT00508365 | Hypertension | Phase 1 | Completed | - | United States, Alabama ... more >> GSK Investigational Site Anniston, Alabama, United States, 36207 United States, Arizona GSK Investigational Site Glendale, Arizona, United States, 85308 United States, California GSK Investigational Site Anaheim, California, United States, 92801 GSK Investigational Site Beverly Hills, California, United States, 90211 GSK Investigational Site Long Beach, California, United States, 90806 United States, Florida GSK Investigational Site Coral Gables, Florida, United States, 33134 GSK Investigational Site Miami, Florida, United States, 33169 GSK Investigational Site Sarasota, Florida, United States, 34239 GSK Investigational Site West Palm Beach, Florida, United States, 33409 United States, Idaho GSK Investigational Site Boise, Idaho, United States, 83704 United States, Indiana GSK Investigational Site Indianapolis, Indiana, United States, 46260 United States, Nevada GSK Investigational Site Las Vegas, Nevada, United States, 89119 United States, New Jersey GSK Investigational Site Hackensack, New Jersey, United States, 07601 United States, North Dakota GSK Investigational Site Fargo, North Dakota, United States, 58103 United States, Ohio GSK Investigational Site Cleveland, Ohio, United States, 44122 United States, Oklahoma GSK Investigational Site Oklahoma City, Oklahoma, United States, 73132 United States, Oregon GSK Investigational Site Portland, Oregon, United States, 97239 United States, Texas GSK Investigational Site Austin, Texas, United States, 78704 GSK Investigational Site Houston, Texas, United States, 77081 GSK Investigational Site San Antonio, Texas, United States, 78229 Collapse << |
| NCT00883064 | Hypertension | Phase 1 | Completed | - | - |
| NCT00552708 | Hypertension | Phase 1 | Completed | - | United States, Washington ... more >> GSK Investigational Site Tacoma, Washington, United States, 98418 Collapse << |
| NCT02070510 | Diabetes Heal... more >>thy Collapse << | Phase 1 | Completed | - | Germany ... more >> Berlin, Germany, 14050 Collapse << |
| NCT01126697 | Duchenne Muscular Dystrophy ... more >> Becker Muscular Dystrophy Limb Girdle Muscular Dystrophy Collapse << | Phase 2 Phase 3 | Completed | - | United States, District of Col... more >>umbia Children's National Medical Center Washington, District of Columbia, United States, 20010 United States, Illinois Lurie Children's Hospital Chicago, Illinois, United States United States, North Carolina Carolinas Medical Center Charlotte, North Carolina, United States United States, Pennsylvania University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 United States, Tennessee University of Tennessee Memphis, Tennessee, United States Canada, Alberta Alberta Children's Hospital Calgary, Alberta, Canada Japan National Center of Neurology and Psychiatry Tokyo, Japan Collapse << |
| NCT01009918 | Breast Cancer ... more >> Cardiac Toxicity Collapse << | Phase 2 | Active, not recruiting | November 2018 | - |
| NCT01982695 | - | - | Completed | - | - |
| NCT00459056 | Abdominal Obesity ... more >> Hypertension Collapse << | Phase 3 | Completed | - | United States, Minnesota ... more >> St. Paul Heart Clinic St. Paul, Minnesota, United States, 55102 Collapse << |
| NCT01258764 | Hypertension, Grade 1 ... more >> Hypertension Treatment N of 1 Study Design Hypertension Collapse << | Not Applicable | Completed | - | United States, California ... more >> Scripps Clinic La Jolla, California, United States, 92037 Collapse << |
| NCT01982695 | Duchenne Muscular Dystrophy (D... more >>MD) Cardiomyopathy Collapse << | Not Applicable | Completed | - | United States, California ... more >> University of California Davis Davis, California, United States United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States United States, Massachusetts Boston Children's Hospital Boston, Massachusetts, United States United States, Minnesota University of Minnesota St. Paul, Minnesota, United States United States, Missouri St. Louis Children's Hospital St. Louise, Missouri, United States United States, Ohio Nationwide Children's Hospital Columbus, Ohio, United States Collapse << |
| NCT00624065 | Hypertension | Phase 3 | Completed | - | - |
| NCT00459056 | - | - | Completed | - | - |
| NCT01984164 | Hypertension ... more >>Mild Cognitive Impairment Collapse << | Phase 3 | Active, not recruiting | December 15, 2018 | United States, Georgia ... more >> Emory Univeristy Atlanta, Georgia, United States, 30329 Collapse << |
| NCT00624065 | - | - | Completed | - | - |
| NCT01827878 | Fed | Phase 1 | Completed | - | India ... more >> Accutest Research Lab (I) Pvt. Ltd. Ahmedabad, Gujarat, India, 380059 Collapse << |
| NCT01380431 | To Determine Bioequivalence Un... more >>der Fed Conditions Collapse << | Phase 1 | Completed | - | United States, Maryland ... more >> PharmaKinetics Laboratories, Inc. Baltimore, Maryland, United States, 21201 Collapse << |
| NCT02232308 | Gastroparesis | Phase 1 | Completed | - | United States, Minnesota ... more >> Mayo Clinic in Rochester Rochester, Minnesota, United States, 55905 Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse << |
| NCT01831700 | Fasting | Phase 1 | Completed | - | India ... more >> Accutest Research Lab (I) Pvt. Ltd. Ahmedabad, Gujarat, India, 380059 Collapse << |
| NCT01735318 | Fasting | Phase 1 | Completed | - | India ... more >> Accutest Research Lab (I) Pvt. Ltd. Navi-Mumbai, Maharashtra, India Collapse << |
| NCT01076140 | Hypertension | Not Applicable | Withdrawn(No participants enro... more >>lled) Collapse << | August 2011 | United States, Mississippi ... more >> University of Mississippi Medical Center Jackson, Mississippi, United States, 39216 Collapse << |
| NCT01735344 | Fed | Phase 1 | Completed | - | India ... more >> Accutest Research Lab (I) Pvt. Ltd. Navi-Mumbai, Gujarat, India Collapse << |
| NCT01066572 | Stroke | Phase 1 | Completed | - | United Kingdom ... more >> Wansbeck General Hospital Ashington, Northumberland, United Kingdom, NE63 9JJ Royal Victoria Infirmary, Queen Victoria Road Newcastle upon Tyne, Tyne and Wear, United Kingdom, NE1 4LP North East Ambulance Service NHS Trust Newcastle upon Tyne, Tyne and Wear, United Kingdom, NE15 8NY North Tyneside General Hospital North Shields, Tyne and Wear, United Kingdom, NE29 8NH Collapse << |
| NCT01375244 | Healthy | Phase 1 | Completed | - | United States, Maryland ... more >> PharmaKinetics Laboratories, Inc. Baltimore, Maryland, United States, 21201 Collapse << |
| NCT03392740 | Cardiomyopathy Due to Drug ... more >> Heart Failure, Systolic Collapse << | Phase 4 | Not yet recruiting | March 15, 2020 | United States, Michigan ... more >> Genesys Regional Medical Center Not yet recruiting Grand Blanc, Michigan, United States, 48439 Contact: Andrew A Hinojos 602-399-1174 andrew.hinojos@ascension.org Contact: Thomas Miller thomas.miller@ascension.org Collapse << |
| NCT01491919 | Hypertension | Phase 1 | Completed | - | United States, Alabama ... more >> University of Alabama Birmingham, Alabama, United States, 35233 United States, Arkansas Arkansas Children's Hospital Little Rock, Arkansas, United States, 72202 United States, Georgia Emory University and Children's Healthcare of Atlanta Atlanta, Georgia, United States, 30322 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48109 United States, Missouri Children's Mercy Hospitals & Clinics Kansas City, Missouri, United States, 64108 United States, New York New York University Langone Medical Center New York, New York, United States, 10016 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229 Collapse << |
| NCT00347360 | Hypertension | Phase 3 | Completed | - | - |
| NCT00347360 | - | - | Completed | - | - |
| NCT01491919 | - | - | Completed | - | - |
| NCT02184858 | Primary Hypertension ... more >> Secondary Hypertension Collapse << | Phase 4 | Completed | - | Belgium ... more >> Department of Pediatrics and Medical Genetics Ghent, Belgium, 9000 Collapse << |
| NCT01409837 | Oligospermia | Phase 2 | Completed | - | Nigeria ... more >> University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria, 01129 Collapse << |
| NCT01835418 | Hypertension | Not Applicable | Unknown | - | - |
| NCT01880528 | Dyspnea Non-s... more >>mall Cell Lung Cancer Small Cell Lung Cancer Collapse << | Not Applicable | Active, not recruiting | November 1, 2018 | United States, Arizona ... more >> Mayo Clinic in Arizona Scottsdale, Arizona, United States, 85259 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Nebraska University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 Collapse << |
| NCT01936012 | Healthy | Not Applicable | Completed | - | Indonesia ... more >> PT Equilab International Jakarta, Indonesia, 12430 Collapse << |
| NCT03599466 | Healthy | Phase 1 | Not yet recruiting | April 2019 | - |
| NCT01409837 | - | - | Completed | - | - |
| 靶点 | Description | IC50 |
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