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CAS No.: 1422365-93-2
Synonyms: HL156A
IM156 is a metformin derivative which has been reported to ameliorate various types of fibrosis and inhibit in vitro and in vivo tumors by inducing AMPK activation more potently than metformin. IM156 treatment impaired the function of virus-specific memory CD8+ T cells, indicating that excessive AMPK activation weakens memory T cell differentiation, thereby suppressing recall immune responses. IM156 activated AMPK in a dose-dependent manner, and produced shortening of the circadian period and enhanced degradation of the clock genes PER2 and CRY1.
实验方案
技术信息
CAS号 | 1422365-93-2 | 储存条件 |
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分子式 | C13H16F3N5O | 运输 | 蓝冰 | |||||||
分子量 | 315.29 | 别名 | HL156A | |||||||
溶解度 |
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动物实验配方 |
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