生物活性

• 描述Lofexidine hydrochloride is an α2A-adrenergic receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02363998	Opioid Withdrawal	Phase 3	Completed	-	United States, Arkansas ... more >> Little Rock, Arkansas, United States, 72211 Springdale, Arkansas, United States, 72764 United States, California San Diego, California, United States, 92103 United States, Florida Fort Lauderdale, Florida, United States, 33308 Hollywood, Florida, United States, 33021 Orlando, Florida, United States, 32801 United States, Georgia Atlanta, Georgia, United States, 30331 United States, Illinois Winfield, Illinois, United States, 60190 United States, Louisiana Lake Charles, Louisiana, United States, 70629 United States, Maryland Rockville, Maryland, United States, 20853 United States, Mississippi Flowood, Mississippi, United States, 39232 United States, Missouri Saint Louis, Missouri, United States, 63141 United States, New York New York, New York, United States, 10019 United States, Ohio Dayton, Ohio, United States, 45417 United States, Oregon Portland, Oregon, United States, 97214 United States, Pennsylvania Pittsburgh, Pennsylvania, United States, 15213 United States, South Carolina North Charleston, South Carolina, United States, 29405 United States, Utah Orem, Utah, United States, 84058 Collapse <<
  NCT01020019	Cannabis Dependence ... more >> Marijuana Dependence Collapse <<	Phase 2 Phase 3	Completed	-	United States, New York ... more >> New York State Psychiatric Institute New York, New York, United States, 10032 Collapse <<
  NCT01020019	-	-	Completed	-	-

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• 参考文献

• [1] Al-Ghananeem AM. Pharmacokinetics of lofexidine hydrochloride in healthy volunteers. J Pharm Sci. 2009 Jan;98(1):319-26.

  [2] Stones RW, Bradbury L, et al. Randomized placebo controlled trial of lofexidine hydrochloride for chronic pelvic pain in women. Hum Reprod. 2001 Aug;16(8):1719-21.