生物活性

• 描述Loteprednol etabonate is a corticosteroid which is the product of 'soft drug' design (synthesis of a compound that undergoes predictable metabolism to inactive metabolites after its therapeutic effects have been expressed at or near the site of application). Loteprednol etabonate can reduce ocular inflammation caused by cataract surgery, seasonal allergic conjunctivitis or contact lens wear. The benign tolerability profile of loteprednol etabonate, in particular its low propensity to cause elevated IOP (when used in the short term) is an attractive characteristic^[3]. LE (Loteprednol Etabonate) relieves ocular surface and lacrimal gland inflammation associated with dry eye and is used in combination with ciclosporin A as a treatment of dry eye^[4]. In vivo animal studies, loteprednol effectively inhibited allergically induced vascular leakage in the nasal cavity of actively sensitized Brown Norway rats and rhinorrhea in actively sensitized domestic pigs following nasal challenge. In several models of allergic asthma, it was clearly demonstrated that loteprednol was able to suppress the allergically induced late phase eosinophilia in mice, rats and guinea pigs.^[5].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00905762	Healthy	Phase 1	Completed	-	United States, New York ... more >> Bausch & Lomb Incorporated Rochester, New York, United States, 14609 Collapse <<
  NCT02163824	Ocular Infections, Irritations... more >> and Inflammations Collapse <<	Phase 3	Completed	-	United States, California ... more >> Sall Research Medical Center Artesia, California, United States, 90701 North Valley Eye Medical Group Mission Hills, California, United States, 91345 Martel Eye Medical Group Rancho Cordova, California, United States, 95670 Wolstan & Goldberg Eye Associates Torrance, California, United States, 90505 United States, Georgia Clayton Eye Center Morrow, Georgia, United States, 30260 United States, Indiana Price Vision Group Indianapolis, Indiana, United States, 46260 John-Kenyon American Eye Institute New Albany, Indiana, United States, 47150 United States, Kentucky Taustine Eye Center Louisville, Kentucky, United States, 40217 United States, Missouri Tauber Eye Center Kansas City, Missouri, United States, 64111 Tekwani Vision Center Saint Louis, Missouri, United States, 63128 Ophthalmology Associates Saint Louis, Missouri, United States, 63131 Ophthalmology Consultants Saint Louis, Missouri, United States, 63131 United States, Nevada Las Vegas Physicians Research Group Henderson, Nevada, United States, 89052 United States, New York Raymond Fong, MDPC New York, New York, United States, 10013 Rochester Ophthalmological Group, PC Rochester, New York, United States, 14618 United States, North Carolina Cornerstone Eye Care High Point, North Carolina, United States, 27262 United States, Ohio Cincinnati Eye Institute Cincinnati, Ohio, United States, 45242 The Eye Center of Columbus Columbus, Ohio, United States, 43215 United States, South Carolina Westside Research, LLC Spartanburg, South Carolina, United States, 29306 United States, Texas The Eye Clinic of Texas, Affiliate of Houston Eye Associates League City, Texas, United States, 77573 R&R Eye Research, LLC San Antonio, Texas, United States, 78229 Kozlovsky Delay & Winter Eye Consultants, LLC San Antonio, Texas, United States, 78230 United States, Virginia Virginia Eye Consultants Norfolk, Virginia, United States, 23502 Collapse <<
  NCT02813265	Dry Eye Syndromes ... more >> Keratoconjunctivitis Sicca Collapse <<	Phase 3	Completed	-	-

• 更多
• 参考文献

• [1] Buris LF, Bodor N, Buris L. Loteprednol etabonate, a new soft steroid is effective in a rabbit acute experimental model for arthritis. Pharmazie. 1999 Jan;54(1):58-61.

  [2] Druzgala P, Hochhaus G, Bodor N. Soft drugs--10. Blanching activity and receptor binding affinity of a new type of glucocorticoid: loteprednol etabonate. J Steroid Biochem Mol Biol. 1991 Feb;38(2):149-54.

  [3] Noble S, Goa KL. Loteprednol etabonate: clinical potential in the management of ocular inflammation. BioDrugs. 1998 Oct;10(4):329-39.

  [4] Pavesio CE, Decory HH. Treatment of ocular inflammatory conditions with loteprednol etabonate. Br J Ophthalmol. 2008 Apr;92(4):455-9

  [5] Szelenyi I, Hochhaus G, Heer S, Kusters S, Marx D, Poppe H, Engel J. Loteprednol etabonate: a soft steroid for the treatment of allergic diseases of the airways. Drugs Today (Barc). 2000 May;36(5):313-20.

• 更多

• Collapse