|(3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(苯并[d]异噻唑-3-基)哌嗪-1-基)甲基)环己基)甲基)六氢-1H-4,7-甲桥异吲哚-1,3(2H)-二酮盐酸盐|CsnPharm

CAS No.: 367514-88-3

Lurasidone HCl/盐酸鲁拉西酮 Catalog No. CSN12364

Synonyms: SM-13496 Hydrochloride;SM-13496;Lurasidone HCl. trade name Latuda

Lurasidone HCl is a multiple-target antagonist of dopamine D2 receptor, 5-HT2 receptor, 5-HT7 receptor, adrenergic α2A and α2C receptors, also works as a partial 5-HT1A receptor agonist. It used as an atypical antipsychotic medication for the treatment of several mental disorders.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 5-HT Receptor 7

IC50:0.495nM Dopamine Receptor D2

IC50:1.68nM Adrenergic Receptor α2C

IC50:10.8nM 5-HT Receptor 2A

IC50:2.03nM 5-HT Receptor 1A

IC50:6.75nM
描述Lurasidone (Hydrochloride) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM. In vitro receptor binding experiments reveal that Lurasidone (Hydrochloride) demonstrates affinity for dopamine D2 and 5-HT2A receptors higher than other tested antipsychotics. Furthermore, lurasidone had only weak extrapyramidal effects in rodent models. In animal models of anxiety disorders and depression, treatment with lurasidone was associated with significant improvement. Lurasidone showed a preferential effect on the frontal cortex (versus striatum) in increasing dopamine turnover. Anti-alpha(1)-noradrenergic, anticholinergic, and central nervous system (CNS) depressant actions of lurasidone were also very weak^[3]. Lurasidone is devoid of antihistaminic and anticholinergic activities. It is administered once daily within the range of 40-160 mg/day for schizophrenia and 20-120 mg/day for bipolar depression, and its pharmacokinetic profile requires administration with food. Lurasidone is principally metabolized by cytochrome P450 (CYP) 3A4 with minor metabolites and should not be coadministered with strong CYP3A4 inducers or inhibitors^[4]. In the ITT (but not the mITT) (modified intention-to-treat) population, treatment with lurasidone was associated with significant improvement in the PANSS (Positive and Negative Syndrome Scale) total score in patients with schizophrenia. Lurasidone was generally well tolerated with minimal impact on weight and metabolic parameters^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01833897	-	-	Completed	-	-
NCT01833897	Bipolar Disorder	Phase 4	Completed	-	United States, New York ... more >> New York State Psychiatric Institute New York, New York, United States, 10032 Collapse <<
NCT01498770	-	-	Completed	-	-

更多
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8899 mL
- 9.4493 mL
- 18.8987 mL
- 5 mM
- 0.3780 mL
- 1.8899 mL
- 3.7797 mL
- 10 mM
- 0.1890 mL
- 0.9449 mL
- 1.8899 mL

技术信息

CAS号

367514-88-3

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C28H37ClN4O2S

运输

蓝冰

分子量

529.14

别名

SM-13496 Hydrochloride;SM-13496;Lurasidone HCl. trade name Latuda;盐酸鲁拉西酮

溶解度

DMSO	1.0 mg/mL (1.9 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01833897	-	-	Completed	-	-
NCT01833897	Bipolar Disorder	Phase 4	Completed	-	United States, New York ... more >> New York State Psychiatric Institute New York, New York, United States, 10032 Collapse <<
NCT01498770	-	-	Completed	-	-
NCT00806234	Psychotic Disorders	Phase 4	Completed	-	United States, Maryland ... more >> University of Maryland Baltimore, Maryland, United States, 21201 Johns Hopkins Hospital Baltimore, Maryland, United States, 21205 United States, New York The Zucker Hillside Hospital Glen Oaks, New York, United States, 11004 United States, North Carolina University of North Carolina, Division of Child and Adolescent Psychiatry Chapel Hill, North Carolina, United States, 27599 Collapse <<
NCT02893371	-	-	Enrolling by invitation	June 2019	United States, New Mexico ... more >> Christophe G Lambert Albuquerque, New Mexico, United States, 87131 Collapse <<
NCT03557931	Schizophrenia	Phase 2	Recruiting	December 2019	United States, Arkansas ... more >> Woodland Research Northwest, LLC Recruiting Rogers, Arkansas, United States, 72758 United States, California CNS Research Science, Inc. Recruiting Cerritos, California, United States, 90703 Collaborative Neuroscience Network, LLC Recruiting Garden Grove, California, United States, 92845 Synergy East Recruiting Lemon Grove, California, United States, 91945 Pacific Research Partners, LLC Recruiting Oakland, California, United States, 94607 California Neuropsychopharmacology Clinical Research Institute-LA, LLC Recruiting Pico Rivera, California, United States, 90660 Artemis Institute for Clinical Research Recruiting San Diego, California, United States, 92103 Sharp Mesa Vista Hospital Recruiting San Diego, California, United States, 92123 Collaborative Neuroscience Network, LLC Recruiting Torrance, California, United States, 90502 United States, Georgia Radiant Research, Inc. Recruiting Atlanta, Georgia, United States, 30328 Atlanta Center for Medical Research Recruiting Atlanta, Georgia, United States, 30331 United States, Illinois Alam Medical Research Inc. Recruiting Chicago, Illinois, United States, 60612 Uptown Research Institute Recruiting Chicago, Illinois, United States, 60640 United States, Michigan Michigan Clinical Research Institute PC Recruiting Ann Arbor, Michigan, United States, 48105 Cherry Street Services, Inc. Recruiting Grand Rapids, Michigan, United States, 49503 United States, New Jersey Hassman Research Institute Recruiting Berlin, New Jersey, United States, 08009 United States, New Mexico Albuquerque Neuroscience Inc. Recruiting Albuquerque, New Mexico, United States, 87109 United States, New York SPRI Clinical Trials, LLC Recruiting Brooklyn, New York, United States, 11235 CNS Research Science, Inc. Recruiting Jamaica, New York, United States, 11432 Manhattan Psychiatric Center's 125th Street Clinic Recruiting New York, New York, United States, 10035 United States, Ohio Midwest Clinical Research Center Recruiting Dayton, Ohio, United States, 45417 United States, Texas InSite Clinical Research, LLC Recruiting DeSoto, Texas, United States, 75115 Pillar Clinical Research, LLC Recruiting Garland, Texas, United States, 75042 Pillar Clinical Research, LLC Recruiting Richardson, Texas, United States, 75080 Collapse <<
NCT00806234	-	-	Completed	-	-
NCT00044044	Schizophrenia	Phase 2	Completed	-	-
NCT02199743	Schizophrenia ... more >> Schizoaffective Disorder Collapse <<	Phase 4	Completed	-	United States, Texas ... more >> UT Southwestern Medical Center Dallas, Texas, United States, 75390 Collapse <<
NCT00044044	-	-	Completed	-	-
NCT00868452	Bipolar Depression	Phase 3	Completed	-	-
NCT02974010	Bipolar Depression ... more >> Suicidal Ideas Suicidal Ideation Suicide, Attempted Collapse <<	Phase 2	Completed	-	United States, Alabama ... more >> Research Site, Birmingham Birmingham, Alabama, United States, 35294 United States, Florida Research Site, Fort Lauderdale Fort Lauderdale, Florida, United States, 33024 United States, North Carolina Research Site, Charlotte Charlotte, North Carolina, United States, 28211 United States, Texas Research Site, Houston Houston, Texas, United States, 77030 Collapse <<
NCT00868452	-	-	Completed	-	-
NCT03304457	Schizophrenia	Phase 4	Completed	-	India ... more >> AIIMS Bhubaneshwar, Odisha, India, 751019 Collapse <<
NCT00044005	Schizophrenia	Phase 2	Completed	-	United States, Alabama ... more >> Birmingham Psychiatry Pharmaceutical Birmingham, Alabama, United States, 35209 United States, California Institute for Psychopharmacology Research Cerritos, California, United States, 90703 CNS Network Garden Grove, California, United States, 92845 California Clinical Trials Medical Group Glendale, California, United States, 91206 Optimum Health Services La Mesa, California, United States, 91942 University of California, Irvine Orange, California, United States, 92868 California Neuropsychopharmacology Clinical Research Institute San Diego, California, United States, 92126 United States, District of Columbia Psychiatric Institute of Washington Washington, District of Columbia, United States, 20016 United States, Florida Comprehensive Neuroscience. Inc. Melbourne, Florida, United States, 32935 Segal Institute for Clinical Research North Miami, Florida, United States, 33161 University of South Florida Tampa, Florida, United States, 33613 Coordinated Research of Florida, Inc Winter Park, Florida, United States, 32789 United States, Hawaii Hawaii Research Center Honolulu, Hawaii, United States, 96826 United States, Illinois Alexian Brothers Behavioral Health Hospital Hoffman Estates, Illinois, United States, 60194 American Medical Research Oakbrook, Illinois, United States, 60523 United States, Nevada Lake Mead Hospital North Las Vegas, Nevada, United States, 89030 United States, New Jersey Comprehensive Clinical Research, CNS Clementon, New Jersey, United States, 08021 ClinSearch, Inc. Kenilworth, New Jersey, United States, 07033 United States, Pennsylvania Quantum Clinical Services Group Philadelphia, Pennsylvania, United States, 19139 Albert Einstein Medical Center Philadelphia, Pennsylvania, United States, 19141 United States, Texas Community Clinical Research Austin, Texas, United States, 78756 FutureSearch Trials Austin, Texas, United States, 78756 Claghorn Lesem Research Clinic, Inc. Bellaire, Texas, United States, 77401 St. Paul Medical Center Dallas, Texas, United States, 75235 United States, Virginia CNS, Inc. Falls Church, Virginia, United States, 22041 United States, Wisconsin Medstream, Inc. Milwaukee, Wisconsin, United States, 53210 Collapse <<
NCT00044005	-	-	Completed	-	-
NCT00088621	Schizophrenia	Phase 2	Completed	-	United States, Alabama ... more >> Birmingham Psychiatry Pharmaceutical Birmingham, Alabama, United States, 35209 United States, Arkansas Summit Research Group Little Rock, Arkansas, United States, 72211 United States, California Comprehensive NeuroScience Cerritos, California, United States, 90703 Collaborative Neuro Science Network, Inc. Garden Grove, California, United States, 92845 Optimum Health Services La Mesa, California, United States, 91942 California Clinical Trials San Diego, California, United States, 92123 CA Neutopsychopharmacology Clinical Research Institute (CNRI) San Diego, California, United States, 92126 Pacific Clinical Research Upland, California, United States, 91786 United States, District of Columbia Comprehensive NeuroScience, Inc Washington, District of Columbia, United States, 20016 United States, Florida Segal Institute for Clinical Research Fort Lauderdale, Florida, United States, 33301 Segal Institute for Clinical Research North Miami, Florida, United States, 33161 University of South Florida, Department of Psychiatry and Behavioral Medicine Tampa, Florida, United States, 33613 United States, Illinois Comprehensive Neuroscience, Inc. Hoffman Estates, Illinois, United States, 60194 United States, Nevada Las Vegas, Nevada, United States, 89102 United States, New Jersey CNS Research Institute Clementon, New Jersey, United States, 08021 United States, Pennsylvania Quantum Clinical Services Group Philadelphia, Pennsylvania, United States, 19139 United States, Texas Community Clinical Research Austin, Texas, United States, 78729 Future Search Trials Austin, Texas, United States, 78756 Claghorn Lesem Research Clinic, Inc. Bellaire, Texas, United States, 77401 InSite Clinical Research DeSoto, Texas, United States, 75115 United States, Virginia CBH Health, L.L.C - Dominion Hospital Falls Church, Virginia, United States, 22044 Collapse <<
NCT00088634	Schizophrenia	Phase 2	Completed	-	United States, Alabama ... more >> Birmingham Psychiatry Pharmaceutical Birmingham, Alabama, United States, 35209 United States, Arkansas Summit Research Group Little Rock, Arkansas, United States, 72211 United States, California Comprehensive NeuroScience Cerritos, California, United States, 90703 Collaborative Neuro Science Network, Inc. Garden Grove, California, United States, 92845 Optimum Health Services La Mesa, California, United States, 91942 California Clinical Trials San Diego, California, United States, 92123 CNRI, LLC San Diego San Diego, California, United States, 92126 Pacific Clinical Research Upland, California, United States, 91786 United States, District of Columbia Comprehensive NeuroScience, Inc Washington, District of Columbia, United States, 20016 United States, Florida Segal Institute for Clinical Research North Miami, Florida, United States, 33161 The Segal Institute North Miami, Florida, United States, 33161 University of South Florida, Department of Psychiatry and Behavioral Medicine Tampa, Florida, United States, 33613 United States, Georgia Atlanta Center for Medical Research Atlanta, Georgia, United States, 30308 United States, Illinois Comprehensive Neuroscience, Inc. Hoffman Estates, Illinois, United States, 60194 United States, Nevada Robert Lynn Horne, MD, Suite 4 Las Vegas, Nevada, United States, 89102 United States, New Jersey CNS Research Institute Clementon, New Jersey, United States, 08021 United States, Pennsylvania Quantum Clinical Services Group Philadelphia, Pennsylvania, United States, 19139 United States, Texas Community Clinical Research Austin, Texas, United States, 78729 Future Search Trials Austin, Texas, United States, 78756 Claghorn-Lesem Research Clinic Bellaire, Texas, United States, 77401 InSite Clinical Research DeSoto, Texas, United States, 75115 United States, Virginia CBH Health, L.L.C - Dominion Hospital Falls Church, Virginia, United States, 22044 Collapse <<
NCT00088634	-	-	Completed	-	-
NCT01173874	Schizophrenia	Phase 3	Completed	-	United States, California ... more >> San Fernando Mental Health Center Granada Hills, California, United States, 91344 University of California - Irvine Orange, California, United States, 92868 United States, Connecticut Yale University New Haven, Connecticut, United States, 06519 United States, Florida University of Miami Department of Psychiatry Miami, Florida, United States, 33136 United States, Georgia Medical College of Georgia Augusta, Georgia, United States, 30912 United States, Illinois Northwestern University Chicago, Illinois, United States, 60611 Rush University Psychiatric Clinical Research Center Chicago, Illinois, United States, 60612 United States, Indiana Indiana University Indianapolis, Indiana, United States, 46222 United States, Massachusetts Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02115 United States, Minnesota University of Minnesota Minneapolis, Minnesota, United States, 55454 United States, Missouri University of Missouri Columbia, Missouri, United States, 65212 United States, New York Columbia University New York, New York, United States, 10032 Psychopharmacology Research Unit- Nathan KIine Institute for Psychiatric Research New York, New York, United States, 10035 United States, North Carolina Duke University Medical Center Butner, North Carolina, United States, 27509 United States, Texas University of Texas Southwestern Medical Center at Dallas Dallas, Texas, United States, 75390 University of Texas Health Science Center, San Antonio San Antonio, Texas, United States, 78229 Collapse <<
NCT02282085	Schizophrenia	Phase 4	Unknown	-	United States, Texas ... more >> UT Southwestern Medical Center Recruiting Dallas, Texas, United States, 75390 Principal Investigator: Matt Byerly, MD Collapse <<
NCT01173874	-	-	Completed	-	-
NCT00868699	Bipolar Depression	Phase 3	Completed	-	-
NCT00088621	-	-	Completed	-	-
NCT02002832	-	-	Unknown	September 2015	China, Beijing ... more >> Bejing Anding Hospital Recruiting Beijing, Beijing, China, 100088 Contact: pending pending pending caizhuoji@126.com Principal Investigator: Gang Wang Collapse <<
NCT00868959	Bipolar Depression	Phase 3	Completed	-	-
NCT00868699	-	-	Completed	-	-
NCT00868959	-	-	Completed	-	-
NCT01082146	Pharmacokinetics ... more >> Metabolism Collapse <<	Phase 1	Completed	-	United States, Wisconsin ... more >> Covance Global Clinical Research Unit Inc. Madison, Wisconsin, United States, 53704 Collapse <<
NCT01284517	Bipolar Depression	Phase 3	Completed	-	-
NCT01566162	Schizophrenia	Phase 3	Completed	-	-
NCT01358357	-	-	Completed	-	-
NCT01566162	-	-	Completed	-	-
NCT01435928	Schizophrenia	Phase 3	Completed	-	-
NCT01485640	Schizophrenia ... more >> Bipolar Disorder Collapse <<	Phase 3	Completed	-	-
NCT01569659	Schizophrenia	Phase 4	Completed	-	United States, Illinois ... more >> Northwestern University Department of Psychiatry and Behavioral Sciences Chicago, Illinois, United States, 60611 Collapse <<
NCT01284517	-	-	Completed	-	-
NCT01575561	Bipolar I Disorder	Phase 3	Completed	-	-
NCT01620060	Schizophrenia ... more >> Autism Collapse <<	Phase 1	Completed	-	United States, Arkansas ... more >> Woodland International Research Group, Inc. Little Rock, Arkansas, United States, 72223 Woodland Northwest Research, LLC Springdale, Arkansas, United States, 72704 United States, California World Wide Research Centers Inc. Murrietta, California, United States, 92562 United States, Florida Segal Institute for Clinical Research Ft. Lauderdale, Florida, United States, 33301 Miami Children's Hospital South Miami, Florida, United States, 33143 United States, Georgia Atlanta Center for Medical Research Atlanta, Georgia, United States, 30308 United States, Ohio University of Cincinnati, Dept. of Psychiatry & Behavioral Neuroscience Cincinnati, Ohio, United States, 45219 University Hospitals Case Medical Center Cleveland, Ohio, United States, 44106 United States, Pennsylvania CRI Worldwide, LLC Philadelphia, Pennsylvania, United States, 19139 United States, Utah Aspen Clinical Research Orem, Utah, United States, 84058 Collapse <<
NCT01435928	-	-	Completed	-	-
NCT01620060	-	-	Completed	-	-
NCT01485640	-	-	Completed	-	-
NCT01358357	Bipolar I Disorder	Phase 3	Completed	-	-
NCT01979679	Schizophrenia	Phase 3	Completed	-	United States, California ... more >> UCI Medical Center Orange, California, United States, 92868 Collapse <<
NCT01932541	Mania Bipolar... more >> I Bipolar II Bipolar Spectrum Disorder Bipolar Disorder Collapse <<	Phase 4	Withdrawn(On hold due to compe... more >>ting departmental studies) Collapse <<	-	United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02144 Collapse <<
NCT01911429	-	-	Completed	-	-
NCT01914393	Schizophrenia ... more >> Autism Bipolar Depression Collapse <<	Phase 3	Completed	-	-
NCT01821378	Schizophrenia	Phase 3	Completed	-	-
NCT01911442	Autism	Phase 3	Completed	-	-
NCT01911429	Schizophrenia	Phase 3	Completed	-	-
NCT02046369	Bipolar I Depression	Phase 3	Completed	-	-
NCT01911442	-	-	Completed	-	-
NCT02174523	Schizophrenia	Phase 1	Completed	-	China, Shanghai ... more >> Xuhui Center Hospital Shanghai, Shanghai, China, 200031 Collapse <<
NCT02046369	-	-	Completed	-	-
NCT02239094	-	-	Completed	-	-
NCT02174510	Schizophrenia	Phase 1	Completed	-	China, Shanghai ... more >> Xuhui Center Hospital Shanghai, Shanghai, China, 200031 Collapse <<
NCT02147379	Bipolar I Disorder	Phase 3	Completed	-	Canada, British Columbia ... more >> University of British Columbia, Department of Psychiatry Vancouver, British Columbia, Canada, V6T 2A1 Collapse <<
NCT01821378	-	-	Completed	-	-
NCT03627195	Schizophrenia	Phase 1	Recruiting	October 15, 2019	United States, California ... more >> Dr. David Walling Recruiting Long Beach, California, United States, 90806 Contact: David Walling, MD 866-787-4257 Collapse <<
NCT02731612	Bipolar Disorder	Phase 3	Recruiting	December 2019	United States, Massachusetts ... more >> The Brigham and Women's Hospital, Department of Psychiatry Recruiting Boston, Massachusetts, United States, 02115 Contact: Megan Shanahan, MHS 617-732-5790 mshanahan2@bwh.harvard.edu Principal Investigator: Katherine Burdick, Ph.D United States, Ohio University Hospitals Cleveland Medical Center Recruiting Cleveland, Ohio, United States, 44106 Contact: Nicole Moomaw, BA 216-844-2863 Nicole.Moomaw@UHhospitals.org Contact: Carla M Conroy, MPH 216.844.2871 Carla.Conroy@UHhospitals.org Principal Investigator: Joseph R Calabrese, MD Canada, British Columbia UBC Mood Disorders Center Recruiting Vancouver, British Columbia, Canada, V6T 1Z3 Contact: Jayasree Basivireddy, PhD 604-822-3769 jayasree.basivireddy@ubc.ca Contact: Nazlin Walji, BSc. 604-822-7294 nazlin.walji@ubc.ca Principal Investigator: Lakshmi N Yatham Japan Department of Psychiatry, University of Occupational and Environmental Health Not yet recruiting Kitakyushu, Fukuoka, Japan, 807-8555 Contact: Reiji Yoshimura, MD, Ph.D 81-93-603-1611 yoshi621@med.uoeh-u.ac.jp Principal Investigator: Reiji Yoshimura, MD, Ph.D Department of Neuropsychiatry, Kansai Medical University Not yet recruiting Moriguchi-shi, Osaka, Japan, 570-8506 Contact: Masaki Kato, MD, Ph.D 81-6-6992-1001 masaaki-ogasa@ds-pharma.co.jp Principal Investigator: Masaki Kato, MD, Ph.D Department of Psychiatry, Hokkaido University Graduate School of Medicine Not yet recruiting Kita-ku, Sapporo, Japan, 060-8638 Contact: Ichiro Kusumi, MD., Ph.D 81-11-706-5160 Principal Investigator: Ichiro Kusumi, MD, Ph.D National Center of Neurology and Psychiatry Not yet recruiting Kodaira, Tokyo, Japan, 187-8551 Contact: Kazuyuki Nakagome, MD, Ph.D 81-42-341-2711 ext 6200 nakagome@guitar.ocn.ne.jp Principal Investigator: Kazuyuki Nakagome, MD, Ph.D Department of Psychiatry, Fujita Health University School of Medicine Not yet recruiting Aichi, Toyoake, Japan, 470-1192 Contact: Nakao Iwata, MD, Ph.D 81-562-93-2000 Principal Investigator: Nakao Iwata, MD, Ph.D Spain Hospital Clinic de Barcelona, Bipolar Disorder Programme Not yet recruiting Barcelona, Spain, 08036 Contact: Marina Garriga, MD 932275400 ext 3130 MAGARRIGA@clinic.cat Principal Investigator: Eduard Vieta, MD United Kingdom Institute of Psychiatry, Psychology and Neuroscience,King's College London Not yet recruiting London, England, United Kingdom, SE5 8AF Contact: Viktoriya Nikolova, BSc MRes 07795401682 viktoriya.nikolova@kcl.ac.uk Principal Investigator: Allan Young, MB.ChB, Mphil, PhD, Collapse <<
NCT01423253	-	-	Completed	-	-
NCT02239094	Bipolar Depression	Not Applicable	Completed	-	United States, New York ... more >> New York State Psychiatric Institute New York, New York, United States, 10032 Collapse <<
NCT01423240	Major Depressive Disorder	Phase 3	Withdrawn	December 2012	-
NCT01421134	Major Depressive Disorder With... more >> Mixed Features Collapse <<	Phase 3	Completed	-	-
NCT01986101	Bipolar Depression	Phase 3	Completed	-	Japan ... more >> Japan 76 sites Tokyo, Japan Lithuania Lithuania 3 sites Kaunas, Lithuania Malaysia Malaysia 5 sites Kuala Lumpur, Malaysia Philippines Philippines 4 sites Manila, Philippines Russian Federation Russia 19 sites Moscow, Russian Federation Slovakia Slovakia 5 sites Zilina, Slovakia Taiwan Taiwan 7 sites Taipei, Taiwan Ukraine Ukraine 9 sites Kiev, Ukraine Collapse <<
NCT01421134	-	-	Completed	-	-
NCT01986114	Bipolar I Disorder	Phase 3	Completed	-	Japan ... more >> Japan 68 sites Tokyo, Japan Lithuania Lithuania 3 sites Kaunas, Lithuania Malaysia Malaysia 5 sites Kuala Lumpur, Malaysia Philippines Philippines 5 sites Manila, Philippines Russian Federation Russia 19 sites Moscow, Russian Federation Slovakia Slovakia 5 sites Zilina, Slovakia Taiwan Taiwan 8 sites Taipei, Taiwan Ukraine Ukraine 9 sites Kiev, Ukraine Collapse <<
NCT03395392	Bipolar Depression ... more >> Suicidal Ideation Collapse <<	Phase 2 Phase 3	Not yet recruiting	March 31, 2019	-
NCT01423253	Major Depressive Disorder	Phase 3	Completed	-	United States, Alabama ... more >> Birmingham Psychiatry Pharmaceutical Studies, Inc Birmingham, Alabama, United States, 35226 United States, California Synergy Clinical Research Center Escondido, California, United States, 92025 Collaborative Neuro Science Network, Inc. Garden Grove, California, United States, 92845 Stanford -VA Palo Alto Health Care System Palo Alto, California, United States, 94304 Artemis Institute for Clinical Research San Diego, California, United States, 92123 United States, Florida Florida Clinical Research Center, LLC Sarasota, Florida, United States, 34201 United States, Massachusetts Massachusetts General Hospital - Center for Anxiety and Traumatic Stress Disorders Boston, Massachusetts, United States, 02114 United States, Missouri St. Charles Psychiatric Associates/Midwest Research Group St. Charles, Missouri, United States, 63301 United States, New York Village Clinical Research Inc. New York, New York, United States, 10003 Finger Lakes Clinical Research Rochester, New York, United States, 14618 Behavioral Medical Research of Staten Island Staten Island, New York, United States, 10305 United States, North Carolina Psychiatry and Behavioral Sciences, Duke Durham, North Carolina, United States, 27705 United States, Ohio Midwest Clinical Research Center Dayton, Ohio, United States, 45408 United States, Pennsylvania CRI Worldwide - Kirkbride Philadelphia, Pennsylvania, United States, 19139 United States, Texas FutureSearch Trials of Dallas, LP Dallas, Texas, United States, 75231 Dept. of Psychiatry, UT Southwestern Medical Center Dallas, Texas, United States, 75390-8849 Grayline Clinical Drug Trials Wichita Falls, Texas, United States, 76309 Collapse <<
NCT03396068	Bipolar Depression ... more >> Suicidal Ideation Collapse <<	Phase 2 Phase 3	Not yet recruiting	March 31, 2020	United States, Alabama ... more >> Research Site Active, not recruiting Birmingham, Alabama, United States, 35294 United States, Florida Research Site Active, not recruiting Fort Lauderdale, Florida, United States, 33024 United States, North Carolina Research Site Active, not recruiting Charlotte, North Carolina, United States, 28211 Collapse <<
NCT01731119	-	-	Completed	-	-
NCT01082289	Schizophrenia	Phase 1	Completed	-	United States, California ... more >> California Clinical Trials Culver City, California, United States, 90232 Collapse <<
NCT01575561	-	-	Completed	-	-
NCT00789698	Chronic Schizophrenia	Phase 3	Completed	-	-
NCT01731119	Schizophrenia ... more >> Schizoaffective Disorder Schizophreniform Disorder Psychosis NOS Autistic Disorder Asperger Syndrome Child Development Disorders, Pervasive Bipolar I Disorder Bipolar II Disorder Mood Disorder NOS Severe Major Depression With Psychotic Features Single Episode Major Depression Without Psychotic Symptoms Severe Mood Disorder With Psychotic Features Collapse <<	Phase 2	Completed	-	United States, North Carolina ... more >> University of North Carolina Chapel Hill, North Carolina, United States, 27517 Collapse <<
NCT00790192	Schizophrenia	Phase 3	Completed	-	-
NCT00790192	-	-	Completed	-	-
NCT00789698	-	-	Completed	-	-
NCT01143077	-	-	Completed	-	-
NCT01143077	Schizophrenia ... more >> Schizoaffective Disorder Collapse <<	Phase 3	Completed	-	-
NCT01082250	Schizophrenia	Phase 1	Completed	-	United States, California ... more >> California Clinical Trials (CCT) Glendale, California, United States, 91206 Collapse <<
NCT01143090	-	-	Completed	-	-
NCT01614899	Schizophrenia	Phase 3	Completed	-	Japan ... more >> 69 Sites Tokyo, Etc, Japan Korea, Republic of 22 Sites Seoul, Etc, Korea, Republic of Malaysia 10 Sites Kuala Lumpur, Etc, Malaysia Taiwan 14 Sites Taipei, Etc, Taiwan Collapse <<
NCT01614912	Schizophrenia	Phase 3	Completed	-	Japan ... more >> 69 Sites Tokyo, Etc, Japan Korea, Republic of 22 Sites Seoul, Etc, Korea, Republic of Malaysia 10 Sites Kuala Lumpur, Etc, Malaysia Taiwan 14Sites Taipei, Etc, Taiwan Collapse <<
NCT01143090	Schizophrenia ... more >> Schizoaffective Disorder Collapse <<	Phase 3	Completed	-	-
NCT03393026	Schizophrenia	Phase 4	Recruiting	August 2019	Taiwan ... more >> Taipei City Hospital, Songde Branch Recruiting Taipei, Taiwan Contact: Shih-Ku Lin, M.D. (02)2726-3141 Tri-Service General Hospital Recruiting Taipei, Taiwan Contact: Chin-Bin Yeh, M.D., Ph.D. 886-2-87923311 Collapse <<
NCT00549666	Pharmacokinetics	Phase 1	Completed	-	United States, California ... more >> Covance Global Clinical Pharmacology, Inc. San Diego, California, United States, 92123 Collapse <<
NCT00641745	-	-	Completed	-	-
NCT01614899	-	-	Completed	-	-
NCT00615433	Schizophrenia	Phase 3	Completed	-	-
NCT00641745	Schizophrenia ... more >> Schizoaffective Disorder Collapse <<	Phase 3	Completed	-	-
NCT01082276	Male, Healthy Normal Subjects	Phase 1	Completed	-	United States, Maryland ... more >> PAREXEL Clinical Pharmacology Research Unit Baltimore, Maryland, United States, 21225 Collapse <<
NCT03402152	Bipolar Depression ... more >> Suicidal Ideation Collapse <<	Phase 2 Phase 3	Recruiting	February 28, 2020	United States, New York ... more >> New York State Psychiatric Institute Recruiting New York, New York, United States, 10032 Contact: Joshua T Kantrowitz, MD 646-774-6738 Joshua.Kantrowitz@nyspi.columbia.edu Collapse <<
NCT00711269	Schizophrenia	Phase 3	Completed	-	Japan ... more >> Japan: 67 sites Tokyo, Etc., Japan Korea, Republic of Korea: 14 sites Seoul, Etc., Korea, Republic of Taiwan Taiwan: 11 sites Taipei, Etc., Taiwan Collapse <<
NCT01614912	-	-	Completed	-	-
NCT00615433	-	-	Completed	-	-
NCT01082263	Schizophrenia Patients	Phase 1	Completed	-	United States, California ... more >> CCT/Parexel Culver City, California, United States, 90232 Collapse <<
NCT00711269	-	-	Completed	-	-
NCT01074073	Schizophrenia	Phase 1	Completed	-	United States, California ... more >> CCT/Parexel Culver City, California, United States, 90232 Collapse <<
NCT00549718	Schizophrenia	Phase 3	Completed	-	-
NCT03465787	Schizophrenia	Phase 3	Recruiting	April 2019	Korea, Republic of ... more >> Borame Medical Center Recruiting Seoul, Seoul, Dongjak-gu, Korea, Republic of, 07061 Contact: Jung Hee Yeon 82-2-870-2461 hyjung@snu.ac.kr Principal Investigator: Jung Hee Yeon, M.D. Collapse <<
NCT00549718	-	-	Completed	-	-
NCT01074632	Schizophrenia, Schizoaffective... more >> Disorder, or Schizophreniform Disorder Collapse <<	Phase 1	Completed	-	United States, California ... more >> California Clinical Trials Glendale, California, United States, 91206 United States, Kansas Clinical Research Institute Wichita, Kansas, United States, 67207 Collapse <<
NCT00806234	Psychotic Disorders	Phase 4	Completed	-	United States, Maryland ... more >> University of Maryland Baltimore, Maryland, United States, 21201 Johns Hopkins Hospital Baltimore, Maryland, United States, 21205 United States, New York The Zucker Hillside Hospital Glen Oaks, New York, United States, 11004 United States, North Carolina University of North Carolina, Division of Child and Adolescent Psychiatry Chapel Hill, North Carolina, United States, 27599 Collapse <<
NCT00806234	-	-	Completed	-	-
NCT01498770	-	-	Completed	-	-
NCT02282085	Schizophrenia	Phase 4	Unknown	-	United States, Texas ... more >> UT Southwestern Medical Center Recruiting Dallas, Texas, United States, 75390 Principal Investigator: Matt Byerly, MD Collapse <<
NCT03557931	Schizophrenia	Phase 2	Recruiting	December 2019	United States, Arkansas ... more >> Woodland Research Northwest, LLC Recruiting Rogers, Arkansas, United States, 72758 United States, California CNS Research Science, Inc. Recruiting Cerritos, California, United States, 90703 Collaborative Neuroscience Network, LLC Recruiting Garden Grove, California, United States, 92845 Synergy East Recruiting Lemon Grove, California, United States, 91945 Pacific Research Partners, LLC Recruiting Oakland, California, United States, 94607 California Neuropsychopharmacology Clinical Research Institute-LA, LLC Recruiting Pico Rivera, California, United States, 90660 Artemis Institute for Clinical Research Recruiting San Diego, California, United States, 92103 Sharp Mesa Vista Hospital Recruiting San Diego, California, United States, 92123 Collaborative Neuroscience Network, LLC Recruiting Torrance, California, United States, 90502 United States, Georgia Radiant Research, Inc. Recruiting Atlanta, Georgia, United States, 30328 Atlanta Center for Medical Research Recruiting Atlanta, Georgia, United States, 30331 United States, Illinois Alam Medical Research Inc. Recruiting Chicago, Illinois, United States, 60612 Uptown Research Institute Recruiting Chicago, Illinois, United States, 60640 United States, Michigan Michigan Clinical Research Institute PC Recruiting Ann Arbor, Michigan, United States, 48105 Cherry Street Services, Inc. Recruiting Grand Rapids, Michigan, United States, 49503 United States, New Jersey Hassman Research Institute Recruiting Berlin, New Jersey, United States, 08009 United States, New Mexico Albuquerque Neuroscience Inc. Recruiting Albuquerque, New Mexico, United States, 87109 United States, New York SPRI Clinical Trials, LLC Recruiting Brooklyn, New York, United States, 11235 CNS Research Science, Inc. Recruiting Jamaica, New York, United States, 11432 Manhattan Psychiatric Center's 125th Street Clinic Recruiting New York, New York, United States, 10035 United States, Ohio Midwest Clinical Research Center Recruiting Dayton, Ohio, United States, 45417 United States, Texas InSite Clinical Research, LLC Recruiting DeSoto, Texas, United States, 75115 Pillar Clinical Research, LLC Recruiting Garland, Texas, United States, 75042 Pillar Clinical Research, LLC Recruiting Richardson, Texas, United States, 75080 Collapse <<
NCT00044044	Schizophrenia	Phase 2	Completed	-	-
NCT02199743	Schizophrenia ... more >> Schizoaffective Disorder Collapse <<	Phase 4	Completed	-	United States, Texas ... more >> UT Southwestern Medical Center Dallas, Texas, United States, 75390 Collapse <<
NCT02893371	-	-	Enrolling by invitation	June 2019	United States, New Mexico ... more >> Christophe G Lambert Albuquerque, New Mexico, United States, 87131 Collapse <<
NCT00044044	-	-	Completed	-	-
NCT00868452	Bipolar Depression	Phase 3	Completed	-	-
NCT02974010	Bipolar Depression ... more >> Suicidal Ideas Suicidal Ideation Suicide, Attempted Collapse <<	Phase 2	Completed	-	United States, Alabama ... more >> Research Site, Birmingham Birmingham, Alabama, United States, 35294 United States, Florida Research Site, Fort Lauderdale Fort Lauderdale, Florida, United States, 33024 United States, North Carolina Research Site, Charlotte Charlotte, North Carolina, United States, 28211 United States, Texas Research Site, Houston Houston, Texas, United States, 77030 Collapse <<
NCT03304457	Schizophrenia	Phase 4	Completed	-	India ... more >> AIIMS Bhubaneshwar, Odisha, India, 751019 Collapse <<
NCT02002832	-	-	Unknown	September 2015	China, Beijing ... more >> Bejing Anding Hospital Recruiting Beijing, Beijing, China, 100088 Contact: pending pending pending caizhuoji@126.com Principal Investigator: Gang Wang Collapse <<
NCT00868452	-	-	Completed	-	-
NCT00044005	Schizophrenia	Phase 2	Completed	-	United States, Alabama ... more >> Birmingham Psychiatry Pharmaceutical Birmingham, Alabama, United States, 35209 United States, California Institute for Psychopharmacology Research Cerritos, California, United States, 90703 CNS Network Garden Grove, California, United States, 92845 California Clinical Trials Medical Group Glendale, California, United States, 91206 Optimum Health Services La Mesa, California, United States, 91942 University of California, Irvine Orange, California, United States, 92868 California Neuropsychopharmacology Clinical Research Institute San Diego, California, United States, 92126 United States, District of Columbia Psychiatric Institute of Washington Washington, District of Columbia, United States, 20016 United States, Florida Comprehensive Neuroscience. Inc. Melbourne, Florida, United States, 32935 Segal Institute for Clinical Research North Miami, Florida, United States, 33161 University of South Florida Tampa, Florida, United States, 33613 Coordinated Research of Florida, Inc Winter Park, Florida, United States, 32789 United States, Hawaii Hawaii Research Center Honolulu, Hawaii, United States, 96826 United States, Illinois Alexian Brothers Behavioral Health Hospital Hoffman Estates, Illinois, United States, 60194 American Medical Research Oakbrook, Illinois, United States, 60523 United States, Nevada Lake Mead Hospital North Las Vegas, Nevada, United States, 89030 United States, New Jersey Comprehensive Clinical Research, CNS Clementon, New Jersey, United States, 08021 ClinSearch, Inc. Kenilworth, New Jersey, United States, 07033 United States, Pennsylvania Quantum Clinical Services Group Philadelphia, Pennsylvania, United States, 19139 Albert Einstein Medical Center Philadelphia, Pennsylvania, United States, 19141 United States, Texas Community Clinical Research Austin, Texas, United States, 78756 FutureSearch Trials Austin, Texas, United States, 78756 Claghorn Lesem Research Clinic, Inc. Bellaire, Texas, United States, 77401 St. Paul Medical Center Dallas, Texas, United States, 75235 United States, Virginia CNS, Inc. Falls Church, Virginia, United States, 22041 United States, Wisconsin Medstream, Inc. Milwaukee, Wisconsin, United States, 53210 Collapse <<
NCT00088621	Schizophrenia	Phase 2	Completed	-	United States, Alabama ... more >> Birmingham Psychiatry Pharmaceutical Birmingham, Alabama, United States, 35209 United States, Arkansas Summit Research Group Little Rock, Arkansas, United States, 72211 United States, California Comprehensive NeuroScience Cerritos, California, United States, 90703 Collaborative Neuro Science Network, Inc. Garden Grove, California, United States, 92845 Optimum Health Services La Mesa, California, United States, 91942 California Clinical Trials San Diego, California, United States, 92123 CA Neutopsychopharmacology Clinical Research Institute (CNRI) San Diego, California, United States, 92126 Pacific Clinical Research Upland, California, United States, 91786 United States, District of Columbia Comprehensive NeuroScience, Inc Washington, District of Columbia, United States, 20016 United States, Florida Segal Institute for Clinical Research Fort Lauderdale, Florida, United States, 33301 Segal Institute for Clinical Research North Miami, Florida, United States, 33161 University of South Florida, Department of Psychiatry and Behavioral Medicine Tampa, Florida, United States, 33613 United States, Illinois Comprehensive Neuroscience, Inc. Hoffman Estates, Illinois, United States, 60194 United States, Nevada Las Vegas, Nevada, United States, 89102 United States, New Jersey CNS Research Institute Clementon, New Jersey, United States, 08021 United States, Pennsylvania Quantum Clinical Services Group Philadelphia, Pennsylvania, United States, 19139 United States, Texas Community Clinical Research Austin, Texas, United States, 78729 Future Search Trials Austin, Texas, United States, 78756 Claghorn Lesem Research Clinic, Inc. Bellaire, Texas, United States, 77401 InSite Clinical Research DeSoto, Texas, United States, 75115 United States, Virginia CBH Health, L.L.C - Dominion Hospital Falls Church, Virginia, United States, 22044 Collapse <<
NCT00088621	-	-	Completed	-	-
NCT00044005	-	-	Completed	-	-
NCT00088634	Schizophrenia	Phase 2	Completed	-	United States, Alabama ... more >> Birmingham Psychiatry Pharmaceutical Birmingham, Alabama, United States, 35209 United States, Arkansas Summit Research Group Little Rock, Arkansas, United States, 72211 United States, California Comprehensive NeuroScience Cerritos, California, United States, 90703 Collaborative Neuro Science Network, Inc. Garden Grove, California, United States, 92845 Optimum Health Services La Mesa, California, United States, 91942 California Clinical Trials San Diego, California, United States, 92123 CNRI, LLC San Diego San Diego, California, United States, 92126 Pacific Clinical Research Upland, California, United States, 91786 United States, District of Columbia Comprehensive NeuroScience, Inc Washington, District of Columbia, United States, 20016 United States, Florida Segal Institute for Clinical Research North Miami, Florida, United States, 33161 The Segal Institute North Miami, Florida, United States, 33161 University of South Florida, Department of Psychiatry and Behavioral Medicine Tampa, Florida, United States, 33613 United States, Georgia Atlanta Center for Medical Research Atlanta, Georgia, United States, 30308 United States, Illinois Comprehensive Neuroscience, Inc. Hoffman Estates, Illinois, United States, 60194 United States, Nevada Robert Lynn Horne, MD, Suite 4 Las Vegas, Nevada, United States, 89102 United States, New Jersey CNS Research Institute Clementon, New Jersey, United States, 08021 United States, Pennsylvania Quantum Clinical Services Group Philadelphia, Pennsylvania, United States, 19139 United States, Texas Community Clinical Research Austin, Texas, United States, 78729 Future Search Trials Austin, Texas, United States, 78756 Claghorn-Lesem Research Clinic Bellaire, Texas, United States, 77401 InSite Clinical Research DeSoto, Texas, United States, 75115 United States, Virginia CBH Health, L.L.C - Dominion Hospital Falls Church, Virginia, United States, 22044 Collapse <<
NCT00088634	-	-	Completed	-	-
NCT00868959	Bipolar Depression	Phase 3	Completed	-	-
NCT00868699	-	-	Completed	-	-
NCT00868959	-	-	Completed	-	-
NCT01173874	Schizophrenia	Phase 3	Completed	-	United States, California ... more >> San Fernando Mental Health Center Granada Hills, California, United States, 91344 University of California - Irvine Orange, California, United States, 92868 United States, Connecticut Yale University New Haven, Connecticut, United States, 06519 United States, Florida University of Miami Department of Psychiatry Miami, Florida, United States, 33136 United States, Georgia Medical College of Georgia Augusta, Georgia, United States, 30912 United States, Illinois Northwestern University Chicago, Illinois, United States, 60611 Rush University Psychiatric Clinical Research Center Chicago, Illinois, United States, 60612 United States, Indiana Indiana University Indianapolis, Indiana, United States, 46222 United States, Massachusetts Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02115 United States, Minnesota University of Minnesota Minneapolis, Minnesota, United States, 55454 United States, Missouri University of Missouri Columbia, Missouri, United States, 65212 United States, New York Columbia University New York, New York, United States, 10032 Psychopharmacology Research Unit- Nathan KIine Institute for Psychiatric Research New York, New York, United States, 10035 United States, North Carolina Duke University Medical Center Butner, North Carolina, United States, 27509 United States, Texas University of Texas Southwestern Medical Center at Dallas Dallas, Texas, United States, 75390 University of Texas Health Science Center, San Antonio San Antonio, Texas, United States, 78229 Collapse <<
NCT01082146	Pharmacokinetics ... more >> Metabolism Collapse <<	Phase 1	Completed	-	United States, Wisconsin ... more >> Covance Global Clinical Research Unit Inc. Madison, Wisconsin, United States, 53704 Collapse <<
NCT01284517	Bipolar Depression	Phase 3	Completed	-	-
NCT00868699	Bipolar Depression	Phase 3	Completed	-	-
NCT01173874	-	-	Completed	-	-
NCT01284517	-	-	Completed	-	-
NCT01358357	Bipolar I Disorder	Phase 3	Completed	-	-
NCT01485640	Schizophrenia ... more >> Bipolar Disorder Collapse <<	Phase 3	Completed	-	-
NCT01358357	-	-	Completed	-	-
NCT01435928	-	-	Completed	-	-
NCT01485640	-	-	Completed	-	-
NCT01566162	Schizophrenia	Phase 3	Completed	-	-
NCT01435928	Schizophrenia	Phase 3	Completed	-	-
NCT01566162	-	-	Completed	-	-
NCT01569659	Schizophrenia	Phase 4	Completed	-	United States, Illinois ... more >> Northwestern University Department of Psychiatry and Behavioral Sciences Chicago, Illinois, United States, 60611 Collapse <<
NCT01575561	-	-	Completed	-	-
NCT01620060	Schizophrenia ... more >> Autism Collapse <<	Phase 1	Completed	-	United States, Arkansas ... more >> Woodland International Research Group, Inc. Little Rock, Arkansas, United States, 72223 Woodland Northwest Research, LLC Springdale, Arkansas, United States, 72704 United States, California World Wide Research Centers Inc. Murrietta, California, United States, 92562 United States, Florida Segal Institute for Clinical Research Ft. Lauderdale, Florida, United States, 33301 Miami Children's Hospital South Miami, Florida, United States, 33143 United States, Georgia Atlanta Center for Medical Research Atlanta, Georgia, United States, 30308 United States, Ohio University of Cincinnati, Dept. of Psychiatry & Behavioral Neuroscience Cincinnati, Ohio, United States, 45219 University Hospitals Case Medical Center Cleveland, Ohio, United States, 44106 United States, Pennsylvania CRI Worldwide, LLC Philadelphia, Pennsylvania, United States, 19139 United States, Utah Aspen Clinical Research Orem, Utah, United States, 84058 Collapse <<
NCT01620060	-	-	Completed	-	-
NCT01821378	Schizophrenia	Phase 3	Completed	-	-
NCT01821378	-	-	Completed	-	-
NCT01575561	Bipolar I Disorder	Phase 3	Completed	-	-
NCT01911429	Schizophrenia	Phase 3	Completed	-	-
NCT01911429	-	-	Completed	-	-
NCT01911442	-	-	Completed	-	-
NCT01914393	Schizophrenia ... more >> Autism Bipolar Depression Collapse <<	Phase 3	Completed	-	-
NCT01932541	Mania Bipolar... more >> I Bipolar II Bipolar Spectrum Disorder Bipolar Disorder Collapse <<	Phase 4	Withdrawn(On hold due to compe... more >>ting departmental studies) Collapse <<	-	United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02144 Collapse <<
NCT01911442	Autism	Phase 3	Completed	-	-
NCT02046369	Bipolar I Depression	Phase 3	Completed	-	-
NCT02147379	Bipolar I Disorder	Phase 3	Completed	-	Canada, British Columbia ... more >> University of British Columbia, Department of Psychiatry Vancouver, British Columbia, Canada, V6T 2A1 Collapse <<
NCT02046369	-	-	Completed	-	-
NCT02174510	Schizophrenia	Phase 1	Completed	-	China, Shanghai ... more >> Xuhui Center Hospital Shanghai, Shanghai, China, 200031 Collapse <<
NCT02239094	Bipolar Depression	Not Applicable	Completed	-	United States, New York ... more >> New York State Psychiatric Institute New York, New York, United States, 10032 Collapse <<
NCT01979679	Schizophrenia	Phase 3	Completed	-	United States, California ... more >> UCI Medical Center Orange, California, United States, 92868 Collapse <<
NCT02174523	Schizophrenia	Phase 1	Completed	-	China, Shanghai ... more >> Xuhui Center Hospital Shanghai, Shanghai, China, 200031 Collapse <<
NCT02731612	Bipolar Disorder	Phase 3	Recruiting	December 2019	United States, Massachusetts ... more >> The Brigham and Women's Hospital, Department of Psychiatry Recruiting Boston, Massachusetts, United States, 02115 Contact: Megan Shanahan, MHS 617-732-5790 mshanahan2@bwh.harvard.edu Principal Investigator: Katherine Burdick, Ph.D United States, Ohio University Hospitals Cleveland Medical Center Recruiting Cleveland, Ohio, United States, 44106 Contact: Nicole Moomaw, BA 216-844-2863 Nicole.Moomaw@UHhospitals.org Contact: Carla M Conroy, MPH 216.844.2871 Carla.Conroy@UHhospitals.org Principal Investigator: Joseph R Calabrese, MD Canada, British Columbia UBC Mood Disorders Center Recruiting Vancouver, British Columbia, Canada, V6T 1Z3 Contact: Jayasree Basivireddy, PhD 604-822-3769 jayasree.basivireddy@ubc.ca Contact: Nazlin Walji, BSc. 604-822-7294 nazlin.walji@ubc.ca Principal Investigator: Lakshmi N Yatham Japan Department of Psychiatry, University of Occupational and Environmental Health Not yet recruiting Kitakyushu, Fukuoka, Japan, 807-8555 Contact: Reiji Yoshimura, MD, Ph.D 81-93-603-1611 yoshi621@med.uoeh-u.ac.jp Principal Investigator: Reiji Yoshimura, MD, Ph.D Department of Neuropsychiatry, Kansai Medical University Not yet recruiting Moriguchi-shi, Osaka, Japan, 570-8506 Contact: Masaki Kato, MD, Ph.D 81-6-6992-1001 masaaki-ogasa@ds-pharma.co.jp Principal Investigator: Masaki Kato, MD, Ph.D Department of Psychiatry, Hokkaido University Graduate School of Medicine Not yet recruiting Kita-ku, Sapporo, Japan, 060-8638 Contact: Ichiro Kusumi, MD., Ph.D 81-11-706-5160 Principal Investigator: Ichiro Kusumi, MD, Ph.D National Center of Neurology and Psychiatry Not yet recruiting Kodaira, Tokyo, Japan, 187-8551 Contact: Kazuyuki Nakagome, MD, Ph.D 81-42-341-2711 ext 6200 nakagome@guitar.ocn.ne.jp Principal Investigator: Kazuyuki Nakagome, MD, Ph.D Department of Psychiatry, Fujita Health University School of Medicine Not yet recruiting Aichi, Toyoake, Japan, 470-1192 Contact: Nakao Iwata, MD, Ph.D 81-562-93-2000 Principal Investigator: Nakao Iwata, MD, Ph.D Spain Hospital Clinic de Barcelona, Bipolar Disorder Programme Not yet recruiting Barcelona, Spain, 08036 Contact: Marina Garriga, MD 932275400 ext 3130 MAGARRIGA@clinic.cat Principal Investigator: Eduard Vieta, MD United Kingdom Institute of Psychiatry, Psychology and Neuroscience,King's College London Not yet recruiting London, England, United Kingdom, SE5 8AF Contact: Viktoriya Nikolova, BSc MRes 07795401682 viktoriya.nikolova@kcl.ac.uk Principal Investigator: Allan Young, MB.ChB, Mphil, PhD, Collapse <<
NCT01731119	Schizophrenia ... more >> Schizoaffective Disorder Schizophreniform Disorder Psychosis NOS Autistic Disorder Asperger Syndrome Child Development Disorders, Pervasive Bipolar I Disorder Bipolar II Disorder Mood Disorder NOS Severe Major Depression With Psychotic Features Single Episode Major Depression Without Psychotic Symptoms Severe Mood Disorder With Psychotic Features Collapse <<	Phase 2	Completed	-	United States, North Carolina ... more >> University of North Carolina Chapel Hill, North Carolina, United States, 27517 Collapse <<
NCT01731119	-	-	Completed	-	-
NCT03627195	Schizophrenia	Phase 1	Recruiting	October 15, 2019	United States, California ... more >> Dr. David Walling Recruiting Long Beach, California, United States, 90806 Contact: David Walling, MD 866-787-4257 Collapse <<
NCT01423253	-	-	Completed	-	-
NCT02239094	-	-	Completed	-	-
NCT01423253	Major Depressive Disorder	Phase 3	Completed	-	United States, Alabama ... more >> Birmingham Psychiatry Pharmaceutical Studies, Inc Birmingham, Alabama, United States, 35226 United States, California Synergy Clinical Research Center Escondido, California, United States, 92025 Collaborative Neuro Science Network, Inc. Garden Grove, California, United States, 92845 Stanford -VA Palo Alto Health Care System Palo Alto, California, United States, 94304 Artemis Institute for Clinical Research San Diego, California, United States, 92123 United States, Florida Florida Clinical Research Center, LLC Sarasota, Florida, United States, 34201 United States, Massachusetts Massachusetts General Hospital - Center for Anxiety and Traumatic Stress Disorders Boston, Massachusetts, United States, 02114 United States, Missouri St. Charles Psychiatric Associates/Midwest Research Group St. Charles, Missouri, United States, 63301 United States, New York Village Clinical Research Inc. New York, New York, United States, 10003 Finger Lakes Clinical Research Rochester, New York, United States, 14618 Behavioral Medical Research of Staten Island Staten Island, New York, United States, 10305 United States, North Carolina Psychiatry and Behavioral Sciences, Duke Durham, North Carolina, United States, 27705 United States, Ohio Midwest Clinical Research Center Dayton, Ohio, United States, 45408 United States, Pennsylvania CRI Worldwide - Kirkbride Philadelphia, Pennsylvania, United States, 19139 United States, Texas FutureSearch Trials of Dallas, LP Dallas, Texas, United States, 75231 Dept. of Psychiatry, UT Southwestern Medical Center Dallas, Texas, United States, 75390-8849 Grayline Clinical Drug Trials Wichita Falls, Texas, United States, 76309 Collapse <<
NCT01421134	-	-	Completed	-	-
NCT01421134	Major Depressive Disorder With... more >> Mixed Features Collapse <<	Phase 3	Completed	-	-
NCT01082289	Schizophrenia	Phase 1	Completed	-	United States, California ... more >> California Clinical Trials Culver City, California, United States, 90232 Collapse <<
NCT01986114	Bipolar I Disorder	Phase 3	Completed	-	Japan ... more >> Japan 68 sites Tokyo, Japan Lithuania Lithuania 3 sites Kaunas, Lithuania Malaysia Malaysia 5 sites Kuala Lumpur, Malaysia Philippines Philippines 5 sites Manila, Philippines Russian Federation Russia 19 sites Moscow, Russian Federation Slovakia Slovakia 5 sites Zilina, Slovakia Taiwan Taiwan 8 sites Taipei, Taiwan Ukraine Ukraine 9 sites Kiev, Ukraine Collapse <<
NCT03402152	Bipolar Depression ... more >> Suicidal Ideation Collapse <<	Phase 2 Phase 3	Recruiting	February 28, 2020	United States, New York ... more >> New York State Psychiatric Institute Recruiting New York, New York, United States, 10032 Contact: Joshua T Kantrowitz, MD 646-774-6738 Joshua.Kantrowitz@nyspi.columbia.edu Collapse <<
NCT01423240	Major Depressive Disorder	Phase 3	Withdrawn	December 2012	-
NCT01986101	Bipolar Depression	Phase 3	Completed	-	Japan ... more >> Japan 76 sites Tokyo, Japan Lithuania Lithuania 3 sites Kaunas, Lithuania Malaysia Malaysia 5 sites Kuala Lumpur, Malaysia Philippines Philippines 4 sites Manila, Philippines Russian Federation Russia 19 sites Moscow, Russian Federation Slovakia Slovakia 5 sites Zilina, Slovakia Taiwan Taiwan 7 sites Taipei, Taiwan Ukraine Ukraine 9 sites Kiev, Ukraine Collapse <<
NCT03395392	Bipolar Depression ... more >> Suicidal Ideation Collapse <<	Phase 2 Phase 3	Not yet recruiting	March 31, 2019	-
NCT00789698	Chronic Schizophrenia	Phase 3	Completed	-	-
NCT00790192	-	-	Completed	-	-
NCT03396068	Bipolar Depression ... more >> Suicidal Ideation Collapse <<	Phase 2 Phase 3	Not yet recruiting	March 31, 2020	United States, Alabama ... more >> Research Site Active, not recruiting Birmingham, Alabama, United States, 35294 United States, Florida Research Site Active, not recruiting Fort Lauderdale, Florida, United States, 33024 United States, North Carolina Research Site Active, not recruiting Charlotte, North Carolina, United States, 28211 Collapse <<
NCT01143077	Schizophrenia ... more >> Schizoaffective Disorder Collapse <<	Phase 3	Completed	-	-
NCT01143090	Schizophrenia ... more >> Schizoaffective Disorder Collapse <<	Phase 3	Completed	-	-
NCT01143077	-	-	Completed	-	-
NCT01143090	-	-	Completed	-	-
NCT01614899	Schizophrenia	Phase 3	Completed	-	Japan ... more >> 69 Sites Tokyo, Etc, Japan Korea, Republic of 22 Sites Seoul, Etc, Korea, Republic of Malaysia 10 Sites Kuala Lumpur, Etc, Malaysia Taiwan 14 Sites Taipei, Etc, Taiwan Collapse <<
NCT00789698	-	-	Completed	-	-
NCT01614912	Schizophrenia	Phase 3	Completed	-	Japan ... more >> 69 Sites Tokyo, Etc, Japan Korea, Republic of 22 Sites Seoul, Etc, Korea, Republic of Malaysia 10 Sites Kuala Lumpur, Etc, Malaysia Taiwan 14Sites Taipei, Etc, Taiwan Collapse <<
NCT01614912	-	-	Completed	-	-
NCT03465787	Schizophrenia	Phase 3	Recruiting	April 2019	Korea, Republic of ... more >> Borame Medical Center Recruiting Seoul, Seoul, Dongjak-gu, Korea, Republic of, 07061 Contact: Jung Hee Yeon 82-2-870-2461 hyjung@snu.ac.kr Principal Investigator: Jung Hee Yeon, M.D. Collapse <<
NCT01614899	-	-	Completed	-	-
NCT00549666	Pharmacokinetics	Phase 1	Completed	-	United States, California ... more >> Covance Global Clinical Pharmacology, Inc. San Diego, California, United States, 92123 Collapse <<
NCT00790192	Schizophrenia	Phase 3	Completed	-	-
NCT00641745	Schizophrenia ... more >> Schizoaffective Disorder Collapse <<	Phase 3	Completed	-	-
NCT00641745	-	-	Completed	-	-
NCT00615433	Schizophrenia	Phase 3	Completed	-	-
NCT01074632	Schizophrenia, Schizoaffective... more >> Disorder, or Schizophreniform Disorder Collapse <<	Phase 1	Completed	-	United States, California ... more >> California Clinical Trials Glendale, California, United States, 91206 United States, Kansas Clinical Research Institute Wichita, Kansas, United States, 67207 Collapse <<
NCT00615433	-	-	Completed	-	-
NCT00711269	Schizophrenia	Phase 3	Completed	-	Japan ... more >> Japan: 67 sites Tokyo, Etc., Japan Korea, Republic of Korea: 14 sites Seoul, Etc., Korea, Republic of Taiwan Taiwan: 11 sites Taipei, Etc., Taiwan Collapse <<
NCT01082263	Schizophrenia Patients	Phase 1	Completed	-	United States, California ... more >> CCT/Parexel Culver City, California, United States, 90232 Collapse <<
NCT01082276	Male, Healthy Normal Subjects	Phase 1	Completed	-	United States, Maryland ... more >> PAREXEL Clinical Pharmacology Research Unit Baltimore, Maryland, United States, 21225 Collapse <<
NCT00549718	-	-	Completed	-	-
NCT01082250	Schizophrenia	Phase 1	Completed	-	United States, California ... more >> California Clinical Trials (CCT) Glendale, California, United States, 91206 Collapse <<
NCT00711269	-	-	Completed	-	-
NCT03393026	Schizophrenia	Phase 4	Recruiting	August 2019	Taiwan ... more >> Taipei City Hospital, Songde Branch Recruiting Taipei, Taiwan Contact: Shih-Ku Lin, M.D. (02)2726-3141 Tri-Service General Hospital Recruiting Taipei, Taiwan Contact: Chin-Bin Yeh, M.D., Ph.D. 886-2-87923311 Collapse <<
NCT00549718	Schizophrenia	Phase 3	Completed	-	-
NCT01074073	Schizophrenia	Phase 1	Completed	-	United States, California ... more >> CCT/Parexel Culver City, California, United States, 90232 Collapse <<

靶点	Description	IC50
5-HT Receptor 7		IC50:0.495nM
Dopamine Receptor D2		IC50:1.68nM
Adrenergic Receptor α2C		IC50:10.8nM
5-HT Receptor 2A		IC50:2.03nM
5-HT Receptor 1A		IC50:6.75nM

Lurasidone HCl/盐酸鲁拉西酮 Catalog No. CSN12364

靶点选择性

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