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CAS No.: 476-28-8

Lycorine/石蒜碱 Catalog No. CSN11349

Synonyms: Galanthidine;Amarylline;Narcissine

Lycorine, a natural product isolated and purified from the bulbus of Lycoris radiata (L. Herit.) Herb, has anti-cancer effect that dependent on STAT expression.

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400-920-2911

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生物活性

描述Lycorine, a natural alkaloid extracted from the Amaryllidaceae plant family, has the potential effect against cancer. Lycorine inhibited proliferation of various PCa cell lines, induced cell apoptosis and cell death. Lycorine inhibited both growth and metastasis in multiple organs (liver, lung, kidney, spleen and bone) in vivo and improved mice survival. Lycorine prevented EGF-induced JAK/STAT signaling^[3]. Lycorine could alleviate LPS-induced lung injury of inflammation and oxidative stress by blocking the HMGB1/TLRs/NF-κB pathway^[4]. Lycorine may inhibit tumor growth of OS (Osteosarcoma) cells possibly through suppressing Wnt/β-catenin, ERK1/2 and PI3K/AKT signaling pathway^[5]. Lycorine (5-40 μM; 16 hours) significantly suppresses SREBFs activity (up to -70%) in a dose-dependent manner and does not cause obvious cytotoxicity in cells. Lycorine (10-20 μM; 2-16 hours) dose- and time-dependently decreases the mature SREBF1 and SREBF2 proteins in HL-7702 cells^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4806 mL
- 17.4028 mL
- 34.8056 mL
- 5 mM
- 0.6961 mL
- 3.4806 mL
- 6.9611 mL
- 10 mM
- 0.3481 mL
- 1.7403 mL
- 3.4806 mL

技术信息

CAS号

476-28-8

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H17NO4

运输

蓝冰

分子量

287.31

别名

Galanthidine;Amarylline;Narcissine;Licorine;Belamarine;Narcissin;NSC-401360;石蒜碱

溶解度

DMSO	128.0 mg/mL (445.5 mM)
Water	insoluble

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