|4-(氨基甲基)苯磺酰胺乙酸酯|CsnPharm

CAS No.: 13009-99-9

Mafenide Acetate/醋酸磺胺米隆 Catalog No. CSN11352

Synonyms: Mafatate;Mafenide acetate;Maphenide acetate

Mafenide Acetate is a synthetic sulfonamide-derived with topical anti-infective activity, which acts through competition with PABA for the bacterial enzyme dihydropteroate synthase and thereby interfering with normal folic acid metabolism.

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技术信息

生物活性

描述Mafenide acetate is an effective but costly antimicrobial solution used for burn wounds^[3]. Hydrofiber saturated with mafenide acetate, whether stored on a dry well plate or nonsterile porcine skin, consistently possessed sustained antimicrobial activity as demonstrated by zones of inhibition greater than 2 mm to both S. aureus and P. aeruginosa^[4]. In wounds treated with mafenide acetate, epithelialization occurred by day 7 in 72% of cases and in 84% by day 21. 52% of the mafenide acetate treated wounds showed reparative activity with inflammatory changes by day 7^[5]. Mafenide acetate and amphotericin B did not seem to persistently meet the toxicity and efficacy balance as consistently as Dakin's solution^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02099240	Osteomyelitis	Early Phase 1	Recruiting	September 2019	United States, Kentucky ... more >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu Sub-Investigator: Forest Arnold, DO Sub-Investigator: Timothy Wiemkwn, PhD Sub-Investigator: Robert Kelley, PhD Sub-Investigator: James Summersgill, PhD Sub-Investigator: Ruth Carrico, PhD Sub-Investigator: Julie Harting, PharmD Sub-Investigator: Paula Peyrani, MD Principal Investigator: David Seligson, MD Sub-Investigator: Craig Roberts, MD Principal Investigator: Julio Ramirez, MD Collapse <<
NCT00675922	Burn	Phase 2 Phase 3	Terminated(Data inconclusive.)	-	United States, Texas ... more >> University of Texas Medical Branch Galveston, Texas, United States, 77555 Collapse <<
NCT00586729	-	-	Completed	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.0604 mL
- 20.3021 mL
- 40.6042 mL
- 5 mM
- 0.8121 mL
- 4.0604 mL
- 8.1208 mL
- 10 mM
- 0.4060 mL
- 2.0302 mL
- 4.0604 mL

技术信息

CAS号

13009-99-9

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H14N2O4S

运输

蓝冰

分子量

246.28

别名

Mafatate;Mafenide acetate;Maphenide acetate;Sulfamilon;Sulfamylon;Winthrocine;醋酸磺胺米隆

溶解度

DMSO	48.0 mg/mL (194.9 mM)
Water	47.0 mg/mL (190.8 mM)
Ethanol	3.0 mg/mL (12.2 mM)

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02099240	Osteomyelitis	Early Phase 1	Recruiting	September 2019	United States, Kentucky ... more >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu Sub-Investigator: Forest Arnold, DO Sub-Investigator: Timothy Wiemkwn, PhD Sub-Investigator: Robert Kelley, PhD Sub-Investigator: James Summersgill, PhD Sub-Investigator: Ruth Carrico, PhD Sub-Investigator: Julie Harting, PharmD Sub-Investigator: Paula Peyrani, MD Principal Investigator: David Seligson, MD Sub-Investigator: Craig Roberts, MD Principal Investigator: Julio Ramirez, MD Collapse <<
NCT00675922	Burn	Phase 2 Phase 3	Terminated(Data inconclusive.)	-	United States, Texas ... more >> University of Texas Medical Branch Galveston, Texas, United States, 77555 Collapse <<
NCT00586729	-	-	Completed	-	-
NCT00675922	-	-	Terminated(Data inconclusive.)	-	-
NCT00586729	Burns	Not Applicable	Completed	-	United States, Arizona ... more >> Maricopa Integrated Health System Phoenix, Arizona, United States, 85008 Collapse <<
NCT01654094	Burns Skin Bu... more >>rn Requiring Skin Graft Collapse <<	Not Applicable	Completed	-	United States, Florida ... more >> Shands at University of Florida Gainesville, Florida, United States, 32610 United States, North Carolina University of North Carolina, Chapel Hill Chapel Hill, North Carolina, United States, 27599 Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 United States, Tennessee University of Tennessee Firefighter's Regional Burn Center Memphis, Tennessee, United States, 38103 Collapse <<
NCT00634166	Burns	Phase 4	Terminated(FDA request as stud... more >>y could not serve as the confirmatory trial as required under Subpart H approval.) Collapse <<	-	United States, Alabama ... more >> University of South Alabama Medical Center Mobile, Alabama, United States, 36617 United States, California Arrowhead Regional Medical Center Redlands, California, United States, 92373 United States, Florida Shands Burn Center - Univ. of Florida Gainesville, Florida, United States, 32610 United States, Illinois Loyola University Medical Center Maywood, Illinois, United States, 60153 The Plastic Surgery Institute - Southern Illinois Univ. School of Medicine Springfield, Illinois, United States, 62794-9653 United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States, 66160 United States, Maryland John's Hopkins Burn Center Baltimore, Maryland, United States, 21224 United States, Missouri University of Missouri Healthcare - Dept. of Surgery Columbia, Missouri, United States, 65212 United States, North Carolina Wake Forest University - Department of General Surgery Winston-Salem, North Carolina, United States, 27157 Collapse <<
NCT00634166	-	-	Terminated(FDA request as stud... more >>y could not serve as the confirmatory trial as required under Subpart H approval.) Collapse <<	-	-

Mafenide Acetate/醋酸磺胺米隆 Catalog No. CSN11352

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