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CAS No.: 4373-41-5

Maslinic acid/山楂酸 Catalog No. CSN10702

Synonyms: Crategolic acid;2α-Hydroxyoleanolic acid;2alpha-Hydroxyoleanolic Acid

Maslinic Acid is a byproduct of olive oil extraction exhibiting antiproliferative effect.

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400-920-2911

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生物活性

实验方案

技术信息

生物活性

描述Maslinic acid is a pentacyclic triterpenoid that is distributed in the peel of olives. Maslinic acid reduced liver weight and liver lipid accumulation and improved hepatocyte steatosis. In liver tissue, maslinic acid suppressed transcription factors involved in lipogenesis and increased adipose triglyceride lipase. In vitro, maslinic acid decreased lipogenesis by activating AMPK^[3]. Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation. 20 μM Maslinic acid significantly suppresses TNF-α production and inhibits IL-1, IL-6, and COX-2 mRNA expression in RAW 264.7 cell. Maslinic acid (at 10 and 20 μM) significantly suppresses the DNA-binding activity of NF-κB p65 in LPS-induced RAW 264.7 cells. Furthermore, Maslinic Acid (200 mg/kg in the edema model or 100 mg/kg in the arthritis model) exerted anti-inflammatory and antiarthritis effects as shown by the suppression of paw edema, arthritis score, inflammatory cells, and destruction of synovium in knee joints^[4]. Maslinic acid inhibit inflammatory effects induced by sPLA2-IIA(Secretory phospholipase A2-IIA is one of the key enzymes causing lipoprotein modification and vascular inflammation), including foam cells formation and PGE2 production^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02520739	Cardiovascular Diseases	Phase 3	Unknown	December 2016	Spain ... more >> University Hospital Virgen de las Nieves Granada, Spain, 18012 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1155 mL
- 10.5775 mL
- 21.1551 mL
- 5 mM
- 0.4231 mL
- 2.1155 mL
- 4.2310 mL
- 10 mM
- 0.2116 mL
- 1.0578 mL
- 2.1155 mL

技术信息

CAS号

4373-41-5

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C30H48O4

运输

蓝冰

分子量

472.70

别名

Crategolic acid;2α-Hydroxyoleanolic acid;2alpha-Hydroxyoleanolic Acid;Maslinic Acid;2α-Hydroxyoleanoic Acid;山楂酸

溶解度

DMSO	100.0 mg/mL (211.6 mM)
Water	insoluble

动物实验配方

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Maslinic acid/山楂酸 Catalog No. CSN10702

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