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CAS No.: 32887-01-7

Mecillinam/美西林 Catalog No. CSN11365

Synonyms: Amdinocillin;FL 1060;Mecillinam Penicillin HX

Mecillinam is an extended-spectrum penicillin antibiotic that binds specifically to penicillin binding protein 2 (PBP2), and is only considered to be active against Gram-negative bacteria.

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生物活性

实验方案

技术信息

生物活性

描述Mecillinam (Amdinocillin), the β-lactam antibiotic, has a broad spectrum of activity against gram-negative organisms. Mecillinam (400 mg per kg) is effective for the treatment of catheterassociated infections at high dosages (400 mg per kg of body weight/d)^[3]. Mecillinam inhibits the essential penicillin-binding protein 2 (PBP2). In clinical isolates of Escherichia coli from urinary tract infections, inactivation of the cysB gene (which encodes the main regulator of cysteine biosynthesis, CysB) is the major cause of resistance^[4]. IV (Intravenous) mecillinam may be a suitable targeted treatment for bacteraemia with a urinary tract focus^[5]. Moreover, 98% of the isolates were found to be mecillinam-susceptible (MIC ≤ 8 mg/l), and 2 % were found to be resistant (MIC > 8 mg/l)^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03228108	Complication ... more >>Infection Prostate Cancer Collapse <<	Phase 4	Not yet recruiting	February 2021	Netherlands ... more >> Catharina Hospital Not yet recruiting Eindhoven, Netherlands Contact: Evert Koldewijn, Dr. +31402397040 evert.koldewijn@catharinaziekenhuis.nl Canisius Wilhelmina Hospital Not yet recruiting Nijmegen, Netherlands Contact: Rik Somford, Dr. +31243658832 r.somford@cwz.nl Radboud University Medical Center Not yet recruiting Nijmegen, Netherlands Contact: Eva Kolwijck, Dr. +31243614356 eva.kolwijck@radboudumc.nl Contact: Sofie Tops-van Kuppevelt, Drs. +31243614356 sofie.tops@radboudumc.nl Collapse <<
NCT03282006	Pyelonephritis ... more >> Urinary Tract Infections Collapse <<	Phase 4	Recruiting	March 2019	Norway ... more >> Vestfold Hospital Trust Recruiting Tønsberg, Vestfold, Norway, 3103 Contact: Tore Stenstad, PhD +004733342000 tore.stenstad@siv.no Contact: Bjørn Åsheim Hansen, MD +004733342000 bjornasheim.hansen@siv.no Collapse <<
NCT02323087	Urinary Tract Infections	Not Applicable	Completed	-	Denmark ... more >> 21 General practices in Copenhagen area Copenhagen, Denmark Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0729 mL
- 15.3645 mL
- 30.7289 mL
- 5 mM
- 0.6146 mL
- 3.0729 mL
- 6.1458 mL
- 10 mM
- 0.3073 mL
- 1.5364 mL
- 3.0729 mL

技术信息

CAS号

32887-01-7

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H23N3O3S

运输

蓝冰

分子量

325.43

别名

Amdinocillin;FL 1060;Mecillinam Penicillin HX;Coactin;Hexacillin;Penicillin Hx

溶解度

DMSO	64.0 mg/mL (196.7 mM)
Water	63.0 mg/mL (193.6 mM)
Ethanol	63.0 mg/mL (193.6 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03228108	Complication ... more >>Infection Prostate Cancer Collapse <<	Phase 4	Not yet recruiting	February 2021	Netherlands ... more >> Catharina Hospital Not yet recruiting Eindhoven, Netherlands Contact: Evert Koldewijn, Dr. +31402397040 evert.koldewijn@catharinaziekenhuis.nl Canisius Wilhelmina Hospital Not yet recruiting Nijmegen, Netherlands Contact: Rik Somford, Dr. +31243658832 r.somford@cwz.nl Radboud University Medical Center Not yet recruiting Nijmegen, Netherlands Contact: Eva Kolwijck, Dr. +31243614356 eva.kolwijck@radboudumc.nl Contact: Sofie Tops-van Kuppevelt, Drs. +31243614356 sofie.tops@radboudumc.nl Collapse <<
NCT03282006	Pyelonephritis ... more >> Urinary Tract Infections Collapse <<	Phase 4	Recruiting	March 2019	Norway ... more >> Vestfold Hospital Trust Recruiting Tønsberg, Vestfold, Norway, 3103 Contact: Tore Stenstad, PhD +004733342000 tore.stenstad@siv.no Contact: Bjørn Åsheim Hansen, MD +004733342000 bjornasheim.hansen@siv.no Collapse <<
NCT02323087	Urinary Tract Infections	Not Applicable	Completed	-	Denmark ... more >> 21 General practices in Copenhagen area Copenhagen, Denmark Collapse <<
NCT01838213	-	-	Completed	-	-
NCT01531023	-	-	Completed	-	Norway ... more >> Vestre Viken Hospital Trust Bærum, Norway University Hospital Akershus Lørenskog, Norway Unilabs Skien, Norway Helse Stavanger HF Stavanger, Norway University Hospital of North Norway Tromsø, Norway St Olavs Hospital Trondheim, Norway Vestfold Hospital Trust Tønsberg, Norway Collapse <<
NCT02083276	Chlamydia Trachomatis Infectio... more >>n Chlamydial Urethritis Collapse <<	Phase 2	Terminated(Treatment failure o... more >>n study medication observed) Collapse <<	-	Norway ... more >> Olafia Clinic,Oslo University Hosptial Oslo, Norway Collapse <<
NCT01838213	-	-	Completed	-	-
NCT01849926	Acute Cystitis (Excl in Pregna... more >>ncy) Collapse <<	Phase 4	Completed	-	Norway ... more >> University of Oslo Oslo, Norway Collapse <<

Mecillinam/美西林 Catalog No. CSN11365

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