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CAS No.: 73816-42-9

Meclocycline Sulfosalicylate Salt/甲环素磺基水杨酸盐 Catalog No. CSN23831

Synonyms: Meclocycline sulfosalicylate salt;Meclan;Mecloderm

Meclocycline Sulfosalicylate Salt is a tetracycline antibiotic with broad-spectrum antibacterial activities, preventing skin bacterial infections such as acne vulgaris[1].

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生物活性

描述Meclocycline sulfosalicylate is bacteriostatic and inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, thereby preventing the addition of amino acids to the growing peptide chain. Meclocycline Sulfosalicylate is a tetracycline antibiotic with broad-spectrum antibacterial activities, preventing skin bacterial infections such as acne vulgaris^[1]. Meclocycline is used topically (i.e. for skin infections) as it is totally insoluble in water and may damage kidney and liver if given systemically^[2]. Contrary to meclocycline, flunoxaprofen does not possess bactericidal and bacteriostatic properties. Contrary to meclocycline, flunoxaprofen induces a precocious increase of Döderlein bacillus, necessary for a definitive normalization and to limit the possibility of relapses^[3]. Meclocycline can produce significant protection of C. elegans from delayed death. Four of the compounds were tested in an ex vivo mouse heart ischemia/reperfusion model and two, meclocycline and 3-amino-1,2,4-triazole, significantly reduced infarction size^[4].
参考文献

[1] Knutson DD, Swinyer LJ, Smoot WH. Meclocycline sulfosalicylate. Topical antibiotic agent for the treatment of acne vulgaris. Cutis. 1981 Feb;27(2):203-4, 208-10
[2] Grio R, Zaccheo F, Marchino GL, Macchioni S, Rustichelli S, Piacentino R, Coppola C. Attività antibatterica della meclociclina (Mecloderm) nelle vaginiti aspecifiche. Studio su 262 casi [Antibacterial activity of meclocycline (Mecloderm) in non-specific vaginitis. Study of 262 cases]. Minerva Ginecol. 1986 Mar;38(3):163-5. Italian
[3] Facchini V, Rispoli G, Dubini F, Bignami P, Sacchi C. Attività di flunoxaprofene per uso topico nelle vaginiti aspecifiche. Confronto con meclociclina solfosalicilato [Activity of topical flunoxaprofen in nonspecific vaginitis. Comparison with meclocycline sulfosalicylate]. Minerva Ginecol. 1989 Dec;41(12):609-14. Italian
[4] Sun CL, Zhang H, Liu M, Wang W, Crowder CM. A screen for protective drugs against delayed hypoxic injury. PLoS One. 2017 Apr 20;12(4):e0176061

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.4388 mL
- 7.1938 mL
- 14.3875 mL
- 5 mM
- 0.2878 mL
- 1.4388 mL
- 2.8775 mL
- 10 mM
- 0.1439 mL
- 0.7194 mL
- 1.4388 mL

技术信息

CAS号

73816-42-9

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C29H27ClN2O14S

运输

蓝冰

分子量

695.05

别名

Meclocycline sulfosalicylate salt;Meclan;Mecloderm;Meclutin;Traumatociclina;甲环素磺基水杨酸盐;磺胺水杨酸甲环素

溶解度

DMSO	240.0 mg/mL (345.3 mM) warming

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Meclocycline Sulfosalicylate Salt/甲环素磺基水杨酸盐 Catalog No. CSN23831

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