|2-((2,3-二甲基苯基)氨基)苯甲酸|CsnPharm

CAS No.: 61-68-7

Mefenamic Acid/甲芬那酸 Catalog No. CSN11372

Synonyms: CI 473;CN-35355;Mefenamic Acid

Mefenamic Acid is an inhibitor of COX2 with anti-inflammatory properties, it's a non-steroidal anti-inflammatory agent.

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技术信息

生物活性

描述Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively^[2]. Mefenamic acid exerted cytotoxic effects on KB, Saos-2, and 1321N cells, where the viability was approximately 75%. U-87MG cells were resistant to mefenamic acid^[3]. Moreover, the memory enhancing activity of mefenamic acid might be due to activation of cholinergic transmission that has protected neuroinflammatory and neurodegenerative conditions caused by alcohol^[4]. Mefenamic acid had anti-inflammatory effects but did not reduce the progression of OA (osteoarthritis) lesions, thereby indicating that it is only effective for symptomatic control of OA^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02580344	Contraception	Phase 2	Completed	-	Egypt ... more >> Assiut university Assiut, Egypt, 71111 Collapse <<
NCT02968823	Pain, Postoperative ... more >> Surgery, Oral Collapse <<	Not Applicable	Recruiting	December 2019	Austria ... more >> MUVienna Recruiting Vienna, Austria Contact: Olga Plattner olga.plattner@meduniwien.ac.at Collapse <<
NCT02943655	Improve Quality of Life ... more >> Heavy Menstrual Bleeding Collapse <<	Phase 3	Recruiting	February 2019	Egypt ... more >> Ahmed Abbas Recruiting Assiut, Cairo, Egypt, 002 Contact: ahmed abbas bmr90@hotmail.com Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.1445 mL
- 20.7224 mL
- 41.4447 mL
- 5 mM
- 0.8289 mL
- 4.1445 mL
- 8.2889 mL
- 10 mM
- 0.4144 mL
- 2.0722 mL
- 4.1445 mL

技术信息

CAS号

61-68-7

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H15NO2

运输

蓝冰

分子量

241.29

别名

CI 473;CN-35355;Mefenamic Acid;C.I. 473;NSC 94437;Ponstel;Parkemed;Coslan;Clonmel Brand of Mefenamic Acid;Mefacit;Mefenamic;Mefenaminic;Antigen Brand of Mefenamic Acid;Apo Mefenamic;甲芬那酸;甲灭酸

溶解度

DMSO	47.0 mg/mL (194.8 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02580344	Contraception	Phase 2	Completed	-	Egypt ... more >> Assiut university Assiut, Egypt, 71111 Collapse <<
NCT02968823	Pain, Postoperative ... more >> Surgery, Oral Collapse <<	Not Applicable	Recruiting	December 2019	Austria ... more >> MUVienna Recruiting Vienna, Austria Contact: Olga Plattner olga.plattner@meduniwien.ac.at Collapse <<
NCT02943655	Improve Quality of Life ... more >> Heavy Menstrual Bleeding Collapse <<	Phase 3	Recruiting	February 2019	Egypt ... more >> Ahmed Abbas Recruiting Assiut, Cairo, Egypt, 002 Contact: ahmed abbas bmr90@hotmail.com Collapse <<
NCT03383133	Metabolic Side Effects of Drug... more >>s Collapse <<	Early Phase 1	Not yet recruiting	April 2018	-
NCT02417337	Pain Postoper... more >>ative Pain Irreversible Pulpitis Collapse <<	Phase 2	Completed	-	Sudan ... more >> University of Khartoum, Faculty of Dentistry, Khartoum, Sudan, 111-11 Collapse <<
NCT01598012	Primary Dysmenorrhea	Phase 4	Completed	-	Thailand ... more >> Gynecologic Endocrinology Unit, Department of Obstetric and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok, Thailand, 10700 Collapse <<
NCT01942122	Endometrioma ... more >>Visual Analogue Pain Scale: Moderate or Severe Pain Collapse <<	Phase 2 Phase 3	Recruiting	February 2019	Indonesia ... more >> Yasmin Clinic, Dr. Cipto Mangunkusumo Hospital (Kencana) Recruiting Jakarta Pusat, Jakarta, Indonesia, 10430 Contact: Kanadi Sumapraja, SpOG(K), MD +6221 3928720 kanadisuma@yahoo.com Contact: Budi Wiweko, SpOG(K), MD +6221 39831098 wiwekobudi@yahoo.co.id Sub-Investigator: R. Muharam, SpOG(K), MD Sub-Investigator: Andon Hestiantoro, SpOG(K), MD Sub-Investigator: Budi Wiweko, SpOG(K), MD Sub-Investigator: Herbert Situmorang, SpOG(K), MD Sub-Investigator: Gita Pratama, SpOG(K), MD Sub-Investigator: Achmad K Harzif, SpOG, MD Sub-Investigator: Mila Maidarti, SpOG, MD Sub-Investigator: Vita Silvana, SpOG, MD Department of Obstetrics and Gynecology, RSUP Persahabatan Recruiting Jakarta Pusat, Jakarta, Indonesia Contact: Botefilia, SpOG (K), MD +62214891708 botefilia@yahoo.com Principal Investigator: Botefilia, SpOG (K), MD Sub-Investigator: Zakia, SpOG, MD Sub-Investigator: Devi Marischa, SpOG, MD Department of Obstetrics and Gynecology RSUP Fatmawati Recruiting Jakarta, Indonesia Contact: Agus S As'adi, SpOG (K), MD +62217501524 agus_surur_asadi@yahoo.com Principal Investigator: Agus S As'adi, SpOG (K), MD Sub-Investigator: Luky S Syahbana, SpOG (K), MD Sub-Investigator: Malvin, SpOG (K), MD Collapse <<
NCT01295294	Uterine Hemorrhage	Phase 4	Completed	-	Denmark ... more >> København NV, Denmark, DK-2400 Odense C, Denmark, DK-5000 Skive, Denmark, DK-7800 Søborg, Denmark, DK-2860 Ålborg, Denmark, DK-9000 Århus C, Denmark, DK-8000 Ireland Mallow, Cork, Ireland Blackrock, Dublin, Ireland Cork, Ireland Norway Elverum, Norway, 2403 Haugesund, Norway, 5507 Trondheim, Norway, 7012 Collapse <<
NCT02183025	Dysmenorrhea	Phase 2	Completed	-	-
NCT03070678	Diabetes Mellitus	Phase 1	Completed	-	France ... more >> Investigational site 250001 Gières, France Collapse <<
NCT03323671	Primary Dysmenorrhea	Phase 2 Phase 3	Completed	-	Egypt ... more >> Mansoura University Mansourah, Egypt, 35516 Collapse <<
NCT01060696	Infertility	Not Applicable	Unknown	May 2010	Thailand ... more >> Siriraj hospital Mahidol university Bangkok, Thailand, 10700 Collapse <<

Mefenamic Acid/甲芬那酸 Catalog No. CSN11372

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