|3-(10,10-二甲基蒽-9(10H)-亚基)-N,N-二甲基丙-1-胺盐酸盐|CsnPharm

CAS No.: 10563-70-9

Melitracen HCl/盐酸美力他欣 Catalog No. CSN23381

Synonyms: Thymeol hydrochloride;N-7001;Melitracen HCl

Melitracen HCl, a member of anthracenes, is an antagonist of dopamine D1 and D2 receptors. It is used as an antidepressant.

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技术信息

生物活性

描述Melitracen HCl is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space. Single oral administration of either Imipramine or Melitracen produces a marked and long lasting mydriasis in mice. The mydriatic effect of Melitracen is more marked and longer lasting. Melitracen is more effective with respect to behavioral excitement. Single oral administration of Melitracen produces lowering of the catechol amine levels in the brain stem, the cerebral cortex, the spleen, and the adrenals^[1]. The efficacy of flupentixol-melitracen in the adjuvant therapy of ulcerative colitis is better than traditional drug treatments^[2]. Flupentixol and melitracen combined with specific immunotherapy could sifnificantlly relieve clinical symptom, quality of life and mental depression.is a safe and reliable therapeutic regimen for further improving clinical symptoms,quality of life,mental statusand the clinical efficacy in moderate to severe persistent with anxiety anddepression^[3].
参考文献

[1] Shimamoto K, Higuchi H, Hattori K. Myriatic effect of 9-(gamma-dimethylamino-propylidene)-10, 10-diemthyl-9, 10-dihydroanthracene hydrochloride (Melitracen) in mice and rats. Acta Sch Med Univ Kioto. 1967;40(1):38‐47
[2] Zhou X, Zhao L, Yang P, Chen Y, Ruan XZ. The Efficacy of Flupentixol-Melitracen in the Adjuvant Therapy of Ulcerative Colitis in the Chinese Population: A Meta-Analysis. Gastroenterol Res Pract. 2019;2019:3480732
[3] Yi ZG, Yang XH, Ren JJ, Peng WH, Liang QL. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017;31(1):34‐37

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0498 mL
- 15.2490 mL
- 30.4980 mL
- 5 mM
- 0.6100 mL
- 3.0498 mL
- 6.0996 mL
- 10 mM
- 0.3050 mL
- 1.5249 mL
- 3.0498 mL

技术信息

CAS号

10563-70-9

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H26ClN

运输

蓝冰

分子量

327.89

别名

Thymeol hydrochloride;N-7001;Melitracen HCl;盐酸美力他欣

溶解度

DMSO	65 mg/ml (198.24 mM)
Water	65 mg/ml (198.24 mM)

动物实验配方

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