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CAS No.: 198821-22-6

Merimepodib Catalog No. CSN16915

Synonyms: VX-497;MMPD;VI-21497

Merimepodiba is a noncompetitive inhibitor of IMPDH (Inosine monophosphate dehydrogenase) with broad spectrum antiviral activities.

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实验方案

技术信息

生物活性

描述Merimepodib (MMPD, VX-497), a potent inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), has shown antiviral activity against HCV and a variety of DNA and RNA viruses in vitro. MMPD inhibits ZIKV (Zika virus) RNA replication with an EC50 of 0.6 μM. Furthermore, MMPD reduces the virus production of ZIKV as well as several other important emerging viral pathogens such as Ebola, Lassa, Chikungunya, and Junin viruses^[3]. VX-497 has intermediate antiviral activity against a second group of viruses, which includes HSV-1, parainfluenza-3 virus, BVDV, VEEV, and dengue virus, with IC50s ranging from 6 to 19 μM. VX-497 is 100-fold more potent, with an IC50 of 380 nM and a corresponding CC50 of 5.2 μM, for a therapeutic index of 14. The antiviral activity of VX-497 in HepG2.2.2.15 cells is reversed threefold by the addition of guanosine^[4]. MPA and VX-497 inhibit both isoforms of IMPDH in vitro. Prolonged treatment of lymphocytes with either VX-497 or MPA did not lead to an increase in type I or type II IMPDH protein levels^[5].
临床研究
NCT号适应症或疾病临床期招募状态预计完成时间地点
NCT00088504 Hepatitis C H... more >>epatitis Collapse << Phase 2 Completed - -
参考文献

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00088504	Hepatitis C H... more >>epatitis Collapse <<	Phase 2	Completed	-	-

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2101 mL
- 11.0507 mL
- 22.1014 mL
- 5 mM
- 0.4420 mL
- 2.2101 mL
- 4.4203 mL
- 10 mM
- 0.2210 mL
- 1.1051 mL
- 2.2101 mL

技术信息

CAS号

198821-22-6

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H24N4O6

运输

蓝冰

分子量

452.46

别名

VX-497;MMPD;VI-21497;MMP

溶解度

DMSO	90.0 mg/mL (198.9 mM)
Water	Insoluble
Ethanol	Insoluble

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