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CAS No.: 173436-66-3

Methyl 3-(4-methylbenzenesulfonamido)benzoate Catalog No. CSN27659

Synonyms: Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate

MSAB is a selective inhibitor of Wnt/β-catenin signaling. It binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes.

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技术信息

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描述Wnt/β-catenin signaling pathway plays crucial roles in multiple stages of development and tissue homeostasis, and its dysregulation can lead to various human diseases. MSAB is a selective inhibitor of Wnt/β-catenin signaling. In HCT116 cells, MSAB resulted in strong inhibition of the TOP-Luc activity in a dose dependent manner. MSAB inhibited proliferation of Wnt-dependent cancer cell lines at concentrations as high as 10 µM. In vivo, MSAB (10 or 20 mg/kg; i.p.; daily for 2 weeks) markedly reduced the size and weight of various types of Wnt-dependent HCT116, HT115, and H23 tumors in xenografted mouse models. Moreover, there was an increase in the level of cleaved caspase 3 in HCT116 and H23 xenograft tumor tissues from mice treated with MSAB, demonstrating that MSAB treatment resulted in apoptotic cell death of tumor xenograft cells leading to subsequent reduction in tumor size^[1].
作用机制MSAB binds to β-catenin promoting its degradation^[1].
参考文献

[1] Hwang SY, et al. Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling. Cell Rep. 2016 Jun 28;16(1):28-36

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2749 mL
- 16.3747 mL
- 32.7494 mL
- 5 mM
- 0.6550 mL
- 3.2749 mL
- 6.5499 mL
- 10 mM
- 0.3275 mL
- 1.6375 mL
- 3.2749 mL

技术信息

CAS号

173436-66-3

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H15NO4S

运输

蓝冰

分子量

305.35

别名

Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate

溶解度

DMSO	61.0 mg/mL (199.8 mM)
Water	Insoluble
Ethanol	10.0 mg/mL (32.7 mM)

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