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CAS No.: 3166-62-9

Methylbenactyzium Bromide Catalog No. CSN21136

Synonyms: Gastrimade;Noinarin;Paragone

Methylbenactyzium Bromide is a mAchR antagonist, used as a spasmolytic for the treatment of gastrointestinal ulcer and gastrointestinal spasms.

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技术信息

生物活性

描述Methylbenactyzium Bromide is a muscarinic acetylcholine receptor (mAChR) inhibitor. Propantheline was highly bound to the membrane and this binding was inhibited to varying extents by several quaternary ammonium compounds. Mepenzolate and methylbenactyzium inhibited it significantly^[2]. Methylbenactyzium bromide was extracted from urine with ODS-cartridge (Sep-Pak C18), then spotted onto a silica gel 60 F254 TLC plate. After development, the separated spot of methylbenactyzium bromide was scraped and wrapped with a ferromagnetic foil without extraction by any organic solvents. A calibration graph prepared by absolute calibration method showed a good linearity over the concentration range of 1-75 micrograms/spot for methylbenactyzium bromide. The coefficient of variation obtained for eleven replicate analyses of the 3 micrograms/spot of standard methylbenactyzium bromide was 3.8%. The detection limit of this compound by this procedure was 0.1 micrograms/spot^[3].
参考文献

[1] Bhattacharjee AK, Pomponio JW, et al. Discovery of subtype selective muscarinic receptor antagonists as alternatives to atropine using in silico pharmacophore modeling and virtual screening methods. Bioorg Med Chem. 2013;21(9):2651-62
[2] Saitoh H, Kobayashi Y, Miyazaki K, Arita T. A highly sensitive HPLC method for the assay of propantheline used to measure its uptake by rat intestinal brush border membrane vesicles. J Pharm Pharmacol. 1987;39(1):9-12
[3] Nishikawa M, Tatsuno M, Suzuki S, Tsuchihashi H. Analysis of methylbenactyzium bromide in human urine by thin-layer chromatography and pyrolysis gas chromatography. Forensic Sci Int. 1991;49(2):197-203

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3677 mL
- 11.8384 mL
- 23.6767 mL
- 5 mM
- 0.4735 mL
- 2.3677 mL
- 4.7353 mL
- 10 mM
- 0.2368 mL
- 1.1838 mL
- 2.3677 mL

技术信息

CAS号

3166-62-9

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H28BrNO3

运输

蓝冰

分子量

422.36

别名

Gastrimade;Noinarin;Paragone;Semulgin;Methylbenactyzium bromide;FWH-101;NSC-11525

溶解度

DMSO	82.0 mg/mL (194.1 mM)
Water	82.0 mg/mL (194.1 mM)
Ethanol	83.0 mg/mL (196.5 mM)

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