|1-(2,6-二甲基苯氧基)-丙基-2-胺盐酸盐|CsnPharm

CAS No.: 5370-01-4

Mexiletine HCl/盐酸美西律 Catalog No. CSN10095

Synonyms: 盐酸美西律;KOE-1173 hydrochloride

Mexiletine HCl is a non-selective blocker of voltage-gated sodium channel. It blongs to the anti-arrhythmic compounds of class IB .

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技术信息

生物活性

描述Mexiletine hydrochloride is a non-selective voltage-gated sodium channel blocker and is a Class IB anti-arrhythmic compound.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02308748	Drug-induced QT Prolongation ... more >> Pharmacokinetics Pharmacodynamics Collapse <<	Phase 1	Completed	-	-
NCT02336477	Non-dystrophic Myotonias ... more >> Paramyotonia Congenita Myotonia Congenita Collapse <<	Phase 3	Completed	-	France ... more >> Groupe Hospitalier Pitié Salpetriere Paris, France, 75013 Collapse <<
NCT02045667	Non Dystrophic Myotonia	Phase 2	Completed	-	Netherlands ... more >> Departments of Neurology, Radboud University Nijmegen Medical Centre, the Netherlands Nijmegen, Gelderland, Netherlands, 6500HB Collapse <<

更多
参考文献

[1] Pietras R, Skibinski R, et al. Validated HPTLC methods for quantification of mexiletine hydrochloride in a pharmaceutical formulation. J AOAC Int. 2010 May-Jun;93(3):820-4.
[2] Asano K, Sameshima T, et al. Attenuating effect of mexiletine hydrochloride on herpetic pain in mice infected with herpes simplex virus. J Pharm Pharmacol. 2003 Oct;55(10):1365-70.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.6356 mL
- 23.1782 mL
- 46.3565 mL
- 5 mM
- 0.9271 mL
- 4.6356 mL
- 9.2713 mL
- 10 mM
- 0.4636 mL
- 2.3178 mL
- 4.6356 mL

技术信息

CAS号

5370-01-4

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C11H18ClNO

运输

蓝冰

分子量

215.72

别名

盐酸美西律;KOE-1173 hydrochloride

溶解度

DMSO	43.0 mg/mL (199.3 mM)
Water	42.0 mg/mL (194.7 mM)
Ethanol	42.0 mg/mL (194.7 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02308748	Drug-induced QT Prolongation ... more >> Pharmacokinetics Pharmacodynamics Collapse <<	Phase 1	Completed	-	-
NCT02336477	Non-dystrophic Myotonias ... more >> Paramyotonia Congenita Myotonia Congenita Collapse <<	Phase 3	Completed	-	France ... more >> Groupe Hospitalier Pitié Salpetriere Paris, France, 75013 Collapse <<
NCT02045667	Non Dystrophic Myotonia	Phase 2	Completed	-	Netherlands ... more >> Departments of Neurology, Radboud University Nijmegen Medical Centre, the Netherlands Nijmegen, Gelderland, Netherlands, 6500HB Collapse <<
NCT02308748	-	-	Completed	-	-
NCT01849770	Sporadic Amyotrophic Lateral S... more >>clerosis Collapse <<	Phase 2	Completed	-	United States, California ... more >> UCLA, Neuromuscular Research Center Los Angeles, California, United States, 90095 United States, Iowa University of Iowa Iowa City, Iowa, United States, 52242 United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States, 66160 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 University of Massachusetts (Worcester) Memorial Medical Center Worcester, Massachusetts, United States, 01655 United States, Missouri Washington University Medical School Saint Louis, Missouri, United States, 63110 United States, New York SUNY Upstate Medical Center Syracuse, New York, United States, 13210 United States, Pennsylvania Penn State Hershey Medical Center Hershey, Pennsylvania, United States, 17033 United States, Texas University of Texas Southwestern Medical Center at Dallas Dallas, Texas, United States, 75390-8897 United States, Washington University of Washington Medical Center Seattle, Washington, United States, 98195 Collapse <<
NCT02114528	Ventricular Tachycardia ... more >> Ventricular Arrhythmia Collapse <<	Phase 4	Terminated(Low recruitment. Pi... more >>lot trial.) Collapse <<	-	Canada, Ontario ... more >> University of Ottawa Heart Institute Ottawa, Ontario, Canada, K1Y 4W7 Collapse <<
NCT01849770	-	-	Completed	-	-
NCT01406873	Myotonic Dystrophy	Phase 2	Completed	-	United States, New York ... more >> University of Rochester Medical Center, Department of Neurology Rochester, New York, United States, 14642 Collapse <<
NCT01406873	-	-	Completed	-	-
NCT02781454	Sporadic Amyotrophic Lateral S... more >>clerosis Collapse <<	Phase 2	Active, not recruiting	December 31, 2018	United States, Arizona ... more >> Barrow Neurological Institute Phoenix, Arizona, United States, 85013 United States, California University of California, Irvine Orange, California, United States, 92868 United States, Georgia Augusta University Augusta, Georgia, United States, 30912 United States, Massachusetts Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48109 United States, New York Columbia Universtiy Medical Center New York, New York, United States, 10032 United States, Pennsylvania Pennsylvania State Hershey Medical Center Hershey, Pennsylvania, United States, 17033 University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 United States, South Carolina Medical University of South Carolina Charleston, South Carolina, United States, 29425 United States, Washington University of Washington Seattle, Washington, United States, 98195 Collapse <<
NCT00000793	HIV Infections ... more >> Peripheral Nervous System Disease Collapse <<	Phase 2	Completed	-	-
NCT02045667	Non Dystrophic Myotonia	Phase 2	Completed	-	Netherlands ... more >> Departments of Neurology, Radboud University Nijmegen Medical Centre, the Netherlands Nijmegen, Gelderland, Netherlands, 6500HB Collapse <<
NCT02308748	-	-	Completed	-	-
NCT02308748	Drug-induced QT Prolongation ... more >> Pharmacokinetics Pharmacodynamics Collapse <<	Phase 1	Completed	-	-
NCT02336477	Non-dystrophic Myotonias ... more >> Paramyotonia Congenita Myotonia Congenita Collapse <<	Phase 3	Completed	-	France ... more >> Groupe Hospitalier Pitié Salpetriere Paris, France, 75013 Collapse <<
NCT01406873	Myotonic Dystrophy	Phase 2	Completed	-	United States, New York ... more >> University of Rochester Medical Center, Department of Neurology Rochester, New York, United States, 14642 Collapse <<
NCT01406873	-	-	Completed	-	-
NCT02114528	Ventricular Tachycardia ... more >> Ventricular Arrhythmia Collapse <<	Phase 4	Terminated(Low recruitment. Pi... more >>lot trial.) Collapse <<	-	Canada, Ontario ... more >> University of Ottawa Heart Institute Ottawa, Ontario, Canada, K1Y 4W7 Collapse <<
NCT00000793	HIV Infections ... more >> Peripheral Nervous System Disease Collapse <<	Phase 2	Completed	-	-
NCT01849770	-	-	Completed	-	-
NCT01849770	Sporadic Amyotrophic Lateral S... more >>clerosis Collapse <<	Phase 2	Completed	-	United States, California ... more >> UCLA, Neuromuscular Research Center Los Angeles, California, United States, 90095 United States, Iowa University of Iowa Iowa City, Iowa, United States, 52242 United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States, 66160 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 University of Massachusetts (Worcester) Memorial Medical Center Worcester, Massachusetts, United States, 01655 United States, Missouri Washington University Medical School Saint Louis, Missouri, United States, 63110 United States, New York SUNY Upstate Medical Center Syracuse, New York, United States, 13210 United States, Pennsylvania Penn State Hershey Medical Center Hershey, Pennsylvania, United States, 17033 United States, Texas University of Texas Southwestern Medical Center at Dallas Dallas, Texas, United States, 75390-8897 United States, Washington University of Washington Medical Center Seattle, Washington, United States, 98195 Collapse <<
NCT02781454	Sporadic Amyotrophic Lateral S... more >>clerosis Collapse <<	Phase 2	Active, not recruiting	December 31, 2018	United States, Arizona ... more >> Barrow Neurological Institute Phoenix, Arizona, United States, 85013 United States, California University of California, Irvine Orange, California, United States, 92868 United States, Georgia Augusta University Augusta, Georgia, United States, 30912 United States, Massachusetts Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48109 United States, New York Columbia Universtiy Medical Center New York, New York, United States, 10032 United States, Pennsylvania Pennsylvania State Hershey Medical Center Hershey, Pennsylvania, United States, 17033 University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 United States, South Carolina Medical University of South Carolina Charleston, South Carolina, United States, 29425 United States, Washington University of Washington Seattle, Washington, United States, 98195 Collapse <<

Mexiletine HCl/盐酸美西律 Catalog No. CSN10095

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