|(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-(((2S,3R,4R,5S,6R)-4-(二甲基氨基)-3-羟基-5-(((2S,4R,5S,6S)-4-羟基-4,6-二甲基-5-(丙酰氧基)四氢-2H-吡喃-2-基)氧基)-6-甲基四氢-2H-吡喃-2-基)氧基)-10-羟基-5-甲氧基-9,16-二甲基-2-氧代-7-(2-氧乙基)氧杂环十六烷基-11,13-二烯基-4-丙酸酯|CsnPharm

CAS No.: 35457-80-8

Midecamycin/麦迪霉素 Catalog No. CSN11442

Synonyms: SF-837;Antibiotic SF-837;Espinomycin A

Midecamycin is a naturally occurring 16-membered macrolide antibiotic, structurely similar to erythromycin.

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描述Midecamycin, an acetoxy-substituted macrolide antibiotic, was tested against gram-positive and gram-negative bacteria. It inhibited the majority of streptococci, staphylococci, and strains of Haemophilus and Listeria at concentrations of less than 3. 1 mM. It was less active than erythromycin, and it failed to inhibit erythromycin-resistant isolates^[3]. Taking into consideration the antimicrobial activity of midecamycin against Mycoplasma pneumoniae, serum concentration and side effects of midecamycin, this antibiotic is expected to be effective in the treatment of Mycoplasma pneumoniae pneumonia^[4]. Midecamycin inhibited SEB-induced (staphylococcal enterotoxin B) mRNA expression of the Th2 cytokines interleukin-4 (IL-4) and IL-5 in PBMCs from patients with AD. Furthermore, Midecamycin also suppressed LTA-induced or PEG-induced (peptidoglycan) IL-5 mRNA expression in these patients^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2285 mL
- 6.1427 mL
- 12.2855 mL
- 5 mM
- 0.2457 mL
- 1.2285 mL
- 2.4571 mL
- 10 mM
- 0.1229 mL
- 0.6143 mL
- 1.2285 mL

技术信息

CAS号

35457-80-8

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C41H67NO15

运输

蓝冰

分子量

813.97

别名

SF-837;Antibiotic SF-837;Espinomycin A;Medecamycin A1;Platenomycin B1;Rubimycin;Turimycin P3;麦迪霉素

溶解度

DMSO	260.0 mg/mL (319.4 mM)
Water	insoluble

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