|3-氟-N'-((5-硝基噻吩-2-基)亚甲基)苯甲酰肼|CsnPharm

CAS No.: 394694-98-5

MitoBloCK-10 Catalog No. CSN27724

Synonyms: MB-10

MitoBloCK-10 is the first small molecule modulator to attenuate PAM (protein-associated motor) complex activity. It binds to a specific pocket in the C-terminal domain of Tim44 of the PAM complex.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述A complex containing the integral membrane proteins Tim17 and Tim23 constitutes the import channel for preproteins containing amino-terminal hydrophilic presequences. This complex is associated with Tim44 which serves as an adaptor protein for the binding of mtHsp70 to the membrane. mtHsp70, a 70 kDa heat shock protein of the mitochondrial matrix, drives the ATP-dependent import reaction of the processed preprotein after cleavage of the presequence^[2]. Tim44 is tightly associated with the inner mitochondrial membrane on the matrix side. The Tim44 C-Terminal Domain (CTD) functions as an Inner Mitochondrial Membrane (IMM) anchor that recruits the Presequence protein Associated Motor (PAM) to the TIM23 channel^[3]. Tim44 plays multiple roles in mitochondrial protein import by recruiting Ssc1 and its J protein cochaperone to the translocon and coordinating their interactions to promote efficient protein translocation in vivo^[4].Hsp70 chaperones interact with substrate proteins in a coordinated fashion that is regulated by nucleotides and enhanced by assisting cochaperones^[5]. MitoBloCK-10 inhibits inner membrane(Tim)44 binding to the precursor and to Hsp70.MitoBloCK-10 is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity. MB-10 (100 μM) is a potential attenuator of protein import into mitochondria.MB-10 inhibits the import of substrates that use the TIM23 import pathway.MB-10 (0-100 μM) inhibits protein import into mammalian mitochondria^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4098 mL
- 17.0489 mL
- 34.0979 mL
- 5 mM
- 0.6820 mL
- 3.4098 mL
- 6.8196 mL
- 10 mM
- 0.3410 mL
- 1.7049 mL
- 3.4098 mL

技术信息

CAS号	394694-98-5	储存条件	粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C12H8FN3O3S	运输	蓝冰
分子量	293.27	别名	MB-10

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

MitoBloCK-10 Catalog No. CSN27724

靶点选择性

请登录您的专属账户

确认信息