CAS No.: 869901-69-9
MK-2048 Catalog No. CSN16815
MK-2048 is a potent inhibitor of integrase and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT02356302 HIV Infections Phase 1 Completed - United States, Alabama ... more >> Alabama CRS Birmingham, Alabama, United States, 35294 United States, Pennsylvania University of Pittsburgh CRS Pittsburgh, Pennsylvania, United States, 15213 Collapse << NCT02419456 HIV Infections Phase 1 Completed - United States, California ... more >> Bridge HIV CRS San Francisco, California, United States, 94143 Collapse << - 参考文献
- [1] Quashie PK, Mesplede T, et al. Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravir. J Virol. 2012 Mar;86(5):2696-705.
- [2] Bar-Magen T, Sloan RD, et al. Comparative biochemical analysis of HIV-1 subtype B and C integrase enzymes. Retrovirology. 2009 Nov 11;6:103.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 869901-69-9 | 储存条件 |
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| 分子式 | C21H21ClFN5O4 | 运输 | 蓝冰 | |
| 分子量 | 461.87 | 别名 |
