CAS No.: 917879-39-1
MK-2461 Catalog No. CSN16566
Synonyms: MK-2461
MK-2461 is a potent and multi-targeted inhibitor for c-Met with IC50 of 0.4-2.5 nM, also inhibits FGFR1/2/3, KDR, TrkA/B, and Flt4 with IC50 of 65/39/50 nM, 44 nM, 46/61 nM, and 78 nM respectively.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00496353 Neoplasm Phase 1 Phase 2 Completed - - NCT00518739 Advanced Cancer Phase 1 Completed - - - 参考文献
- [1] Pan BS, Chan GK, et al. MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33.
- [2] Park YW, Cummings RT, et al. Homogeneous proximity tyrosine kinase assays: scintillation proximity assay versus homogeneous time-resolved fluorescence. Anal Biochem. 1999 Apr 10;269(1):94-104.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 917879-39-1 | 储存条件 |
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| 分子式 | C24H25N5O5S | 运输 | 蓝冰 | |||||||
| 分子量 | 495.55 | 别名 | MK-2461 | |||||||
| 溶解度 |
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动物实验配方 |
