CAS No.: 1030612-90-8
MK-8245 Catalog No. CSN16133
Synonyms: Mk-8245
MK-8245 is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
|---|
400-920-2911
sales@csnpharm.cn
tech@csnpharm.cn
纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00790556 - - Completed - - NCT00790556 Type 2 Diabetes Phase 1 Completed - - NCT00846391 Type 2 Diabetes Mellitus Phase 2 Terminated(Study was terminate... more >>d due to inability to recruit patients.) Collapse << - - - 更多
- 参考文献
- [1] Oballa RM, Belair L, et al. Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. J Med Chem. 2011 Jul 28;54(14):5082-96.
- [2] Bai Y, McCoy JG, Levin EJ, et al. X-ray structure of a mammalian stearoyl-CoA desaturase. Nature. 2015;524(7564):252-256.
- [3] Oballa RM, Belair L, Black WC, et al. Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. J Med Chem. 2011;54(14):5082-5096.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1030612-90-8 | 储存条件 |
|
|||||||||
| 分子式 | C17H16BrFN6O4 | 运输 | 蓝冰 | |||||||||
| 分子量 | 467.25 | 别名 | Mk-8245 | |||||||||
| 溶解度 |
|
动物实验配方 |
|
