CAS No.: 885325-71-3
MK-8745 Catalog No. CSN16817
MK-8745 is a potent and selective Aurora an inhibitor with IC50 of 0.6 nM, more than 450-fold selectivity for Aurora A over Aurora B.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Chowdhury A, Chowdhury S, et al. A novel Aurora kinase A inhibitor MK-8745 predicts TPX2 as a therapeutic biomarker in non-Hodgkin lymphoma cell lines. Leuk Lymphoma. 2012 Mar;53(3):462-71.
- [2] Nair JS, Ho AL, et al. The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent. Cell Cycle. 2012 Feb 15;11(4):807-17.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 885325-71-3 | 储存条件 |
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| 分子式 | C20H19ClFN5OS | 运输 | 蓝冰 | |
| 分子量 | 431.91 | 别名 |
