CAS No.: 1415246-68-2
MMAF Hydrochloride Catalog No. CSN17814
Synonyms: Monomethylauristatin F hydrochloride;Monomethylauristatin-F HCl
MMAF HCl is an antitubulin agent that inhibit cell division. It inhibits H3397 cell growth with an IC50 of 105 nM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Smith LM, Nesterova A, et al. Potent cytotoxicity of an auristatin-containing antibody-drug conjugate targeting melanoma cells expressing melanotransferrin/p97. Mol Cancer Ther. 2006 Jun;5(6):1474-82.
- [2] Doronina SO, Mendelsohn BA, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1415246-68-2 | 储存条件 |
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| 分子式 | C39H66ClN5O8 | 运输 | 蓝冰 | |
| 分子量 | 768.42 | 别名 | Monomethylauristatin F hydrochloride;Monomethylauristatin-F HCl |
