CAS No.: 203192-01-2
MN58b Catalog No. CSN27218
MN58b is a CHKα inhibitor that inhibits phosphocholine synthesis and reduced cell growth through induction of apoptosis.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Mazarico JM, et al. Choline Kinase Alpha (CHKα) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors. Mol Cancer Ther. 2016 Feb;15(2):323-33.
- [2] Al-Saffar NM, et al. Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models. Cancer Res. 2006 Jan 1;66(1):427-34.
- [3] Lacal J. C., et al. Choline Kinase α Inhibitors MN58b and RSM932A enhances the Antitumor Response to Cisplatin in Lung Tumor Cells. Pharmaceutics. 2022, 14(6), 1143.
- [4] Mazarico, J. M., et al. Choline Kinase Alpha (CHKα) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors. Mol Cancer Ther. 2006. 15(2), 323-333.
- [5] AI-Saffar, N. M. S., et al. Noninvasive Magnetic Resonance Spectroscopic Pharmacodynamic Markers of the Choline Kinase Inhibitor MN58b in Human Carcinoma Models. Cancer Res. 2006. 66(1), 427-434.
- [6] Hernando, E., et al. A critical role for choline kinase-α in the aggressiveness of bladder carcinomas. Oncogene. 2009. 28, 2425-2435.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 203192-01-2 | 储存条件 |
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| 分子式 | C32H40Br2N4 | 运输 | 蓝冰 | |||
| 分子量 | 640.49 | 别名 | ||||
| 溶解度 |
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动物实验配方 |
