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CAS No.: 1485-00-3
Synonyms: NSC 170724;5-(2-Nitrovinyl)benzodioxole;3,4-Methylenedioxy-β-Nitrostyrene
MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively. It acts by inhibiting NLRP3 ATPase activity and binding to the NACHT and LRR domains.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT02859558 | HIV-1 Infection | Phase 2 | Recruiting | June 30, 2020 | - |
NCT02410772 | Tuberculosis | Phase 3 | Recruiting | December 2019 | - |
NCT01362244 | Nasal Polyps | Phase 2 | Completed | - | Belgium ... more >> GSK Investigational Site Gent, Belgium, 9000 Netherlands GSK Investigational Site Amsterdam, Netherlands, 1105 AZ United Kingdom GSK Investigational Site Cambridge, United Kingdom GSK Investigational Site London, United Kingdom, EC1M 6BQ GSK Investigational Site London, United Kingdom, SE1 1YR GSK Investigational Site London, United Kingdom, SW3 6NP GSK Investigational Site London, United Kingdom, WC1X 8DA Collapse << |
实验方案
技术信息
CAS号 | 1485-00-3 | 储存条件 |
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分子式 | C9H7NO4 | 运输 | 蓝冰 | |
分子量 | 193.16 | 别名 | NSC 170724;5-(2-Nitrovinyl)benzodioxole;3,4-Methylenedioxy-β-Nitrostyrene;3,4-Methylenedioxy-beta-Nitrostyrene;MDBN;NSC 10120;NSC 105303;Syk Inhibitor III |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT02859558 | HIV-1 Infection | Phase 2 | Recruiting | June 30, 2020 | - |
NCT02410772 | Tuberculosis | Phase 3 | Recruiting | December 2019 | - |
NCT01362244 | Nasal Polyps | Phase 2 | Completed | - | Belgium ... more >> GSK Investigational Site Gent, Belgium, 9000 Netherlands GSK Investigational Site Amsterdam, Netherlands, 1105 AZ United Kingdom GSK Investigational Site Cambridge, United Kingdom GSK Investigational Site London, United Kingdom, EC1M 6BQ GSK Investigational Site London, United Kingdom, SE1 1YR GSK Investigational Site London, United Kingdom, SW3 6NP GSK Investigational Site London, United Kingdom, WC1X 8DA Collapse << |
NCT01508637 | Cardiovascular Effects | Not Applicable | Unknown | December 2015 | United States, Washington ... more >> University of Washington Medical Center Recruiting Seattle, Washington, United States, 98195 Collapse << |
NCT01362244 | - | - | Completed | - | - |
NCT03059628 | Acute Alcohol Intoxication | Not Applicable | Not yet recruiting | June 2019 | France ... more >> Centre Hospitalier Universitaire Amiens Picardie Not yet recruiting Amiens, France, 84054 Contact: Maxime GIGNON, MD gignon.maxime@chu-amiens.fr Centre Hospitalier Universitaire Angers Not yet recruiting Angers, France, 49933 Contact: Aurore ARMAND, MD auarmand@chu-angers.fr Hôpital Saint André Not yet recruiting Bordeaux, France, 35075 Contact: Isabelle FAURE, MD isabelle.faure@chu-bordeaux.fr Hôpital de la Cavale Blanche Not yet recruiting Brest, France, 29200 Contact: David Goetghebeur david.goetghebeur@chu-brest.fr Hôpital d'Instruction des Armées Clermont Tonnerre Not yet recruiting Brest, France, 29240 Contact: Luc SOUQUIERE, MD luc.souquiere@orange.fr Hôpital Bicêtre, AP-HP Not yet recruiting Le Kremlin-Bicêtre, France, 94275 Contact: Maurice RAPHAEL maurice.raphael@aphp.fr Centre Hospitalier Universitaire Rennes Pontchaillou Not yet recruiting Rennes, France, 35000 Contact: Romain MOIRAND, MD/PHD romain.moirand@chu-rennes.fr Contact: Cédric GANGLOFF, MD Cedric.GANGLOFF@chu-rennes.fr Centre Hospitalier Régional Universitaire de Tours - Hôpital trousseau Not yet recruiting Tours, France, 37044 Contact: Paul BRUNAULT, MD/PHD paul.brunault@univ-tours.fr Collapse << |
NCT03110588 | Metastatic Prostate Cancer | Phase 1 | Recruiting | August 1, 2023 | United States, Alabama ... more >> University of Alabama at Birmingham Recruiting Birmingham, Alabama, United States, 35294 Contact: Mansoor N Saleh, MD 205-996-4673 mns@uab.edu Contact: Alfreda Lewis 205-975-9025 FredaLewis@uab.edu Collapse << |
NCT01976806 | Periodontitis ... more >> Gingivitis Inflammation Collapse << | Phase 2 | Completed | - | United States, Massachusetts ... more >> Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Collapse << |
NCT01976806 | - | - | Completed | - | - |
NCT00512603 | - | - | Completed | - | - |
NCT01401608 | - | - | Terminated(Difficult to recrui... more >>t eligible subjects) Collapse << | - | United States, Ohio ... more >> The Ohio State University Columbus, Ohio, United States, 43210 Collapse << |
NCT02136329 | Acute Kidney Injury | Phase 1 | Completed | - | United Kingdom ... more >> Department of Cardiovascular Sciences. Leicester, Leicestershire, United Kingdom, LE3 9QP Collapse << |
NCT01631461 | - | - | Completed | - | - |
NCT02942797 | - | - | Recruiting | March 2019 | China, Sichuan ... more >> West China Hospital Recruiting Chengdu, Sichuan, China, 610041 Contact: Lu Xing, MNS +86 18782942153 xinglu_0707@163.com Contact: Xiaolian Jiang, PhD +86 18980995826 jiang_xiaolian0508@126.com Collapse << |
NCT01131793 | Coronary Artery Disease | Phase 2 | Completed | - | Netherlands ... more >> Erasmus MC University Medical Center Rotterdam, The Netherlands, Netherlands Collapse << |
NCT02854176 | Osteoarthritis, Knee | Phase 2 | Unknown | August 2017 | - |
NCT02228031 | Social Cognition ... more >> Expressed Emotion Collapse << | Early Phase 1 | Completed | - | United States, Maryland ... more >> Child Development Lab, University of Maryland College Park, Maryland, United States, 20742 Collapse << |
NCT03094455 | Hemiplegia He... more >>miplegic Cerebral Palsy Collapse << | Not Applicable | Recruiting | November 29, 2018 | Italy ... more >> IRCCS Stella Maris Foundation Recruiting Calambrone, Pisa, Italy, 56128 Contact: Giovanni Cioni, MD +39 050 886230 g.cioni@fsm.unipi.it Principal Investigator: Giuseppina Sgandurra, MD, PhD Collapse << |
NCT02942784 | - | - | Recruiting | May 2017 | China, Sichuan ... more >> West China Hospital Recruiting Chengdu, Sichuan, China, 610041 Contact: Lu Xing, MNS +86 18782942153 xinglu_0707@163.com Contact: Xiaolian Jiang, PhD +86 18980995826 jiang_xiaolian0508@126.com Collapse << |
NCT02914171 | Ebstein Anomaly | Phase 1 | Recruiting | April 2021 | United States, Minnesota ... more >> Mayo Clinic Recruiting Rochester, Minnesota, United States, 55905 Contact: Karen M Cavanaugh, CCRP 507-538-8425 cavanaugh.karen@mayo.edu Contact: Lori A Riess, CCRP 507-538-7730 riess.lori@mayo.edu Principal Investigator: Muhammad Y Qureshi, MBBS Collapse << |
NCT01635153 | HIV Tuberculo... more >>sis Collapse << | Phase 2 | Completed | - | Tanzania ... more >> Infectious Disease Centre Dar es Salaam, Tanzania Collapse << |
NCT01432288 | - | - | Completed | - | United States, North Carolina ... more >> Center for Biomolecular Imaging and Center for Integrative Medicine, Wake Forest University Winston-Salem, North Carolina, United States, 27157 Collapse << |
NCT01339611 | Cardiovascular Disease ... more >> Venous Thromboses Atrial Fibrillation Blood Coagulation Disorders, Inherited Collapse << | Not Applicable | Unknown | December 2012 | Brazil ... more >> Hospital Estadual de Ribeirão Preto Recruiting Ribeirão Preto, São Paulo, Brazil, 14090140 Contact: Flavia M Pelegrino, RN 16 36023402 flavia-martineli@bol.com.br Contact: Inaiara S Corbi, RN 16 36023402 inaenf@yahoo.com Principal Investigator: Rosana S Dantas, PhD Collapse << |
NCT00994331 | Coronary Artery Disease | Not Applicable | Terminated(Study terminated du... more >>e to lack of enrollment.) Collapse << | - | United States, New York ... more >> New York Presbyterian Hospital-Columbia Medical Center New York, New York, United States, 10032 Collapse << |
NCT01461863 | Low Birth Weight | Not Applicable | Completed | - | Tanzania ... more >> Muhimbili University of Health and Allied Sciences Dar es Salaam, Tanzania Collapse << |
NCT02768428 | Cancer | Not Applicable | Unknown | October 2017 | Thailand ... more >> Chulabhorn Hospital Recruiting Thailand, Bangkok, Thailand, 10210 Contact: Ruechuta Molek, MNS +66818661516 ruechuta.molek@gmail.com Contact: Chaivej Nuchprayoon, Prof. +6625766840 chaivej@hotmail.com Collapse << |
NCT01461863 | - | - | Completed | - | - |
NCT02235350 | Stroke, Acute Hemiplegia, Apra... more >>xia Collapse << | Not Applicable | Unknown | June 2015 | Italy ... more >> Neuromed IRCCS, Istituto Neurologico Mediterraneo Recruiting Pozzilli, Isernia, Italy, 86077 Contact: Giovanni Buccino, MD, PhD buccino@unicz.it Sub-Investigator: Daniela Aprile, PT Collapse << |
NCT00388011 | Hallux Valgus | Phase 2 | Completed | - | - |
NCT00983450 | Stroke | Phase 2 | Unknown | - | Israel ... more >> Hadassah University Hospital Recruiting Jerusalem, Israel Collapse << |
NCT00591981 | - | - | Completed | - | United States, Wisconsin ... more >> University of Wisconsin Hospital Madison, Wisconsin, United States, 53792 Collapse << |
NCT02278068 | Diabetes Endo... more >>crine, Nutritional and Metabolic Diseases (E00-E89) Collapse << | Not Applicable | Active, not recruiting | April 2018 | New Zealand ... more >> Auckland City Hospital Auckland, New Zealand Middlemore Hospital Auckland, New Zealand North Shore Hospital Auckland, New Zealand Christchurch Hospital Christchurch, New Zealand Dunedin Hospital Dunedin, New Zealand Wellington Hospital Wellington, New Zealand Collapse << |
NCT00390039 | Pain, Postoperative | Phase 3 | Completed | - | United States, Arizona ... more >> Arizona Research Center Phoenix, Arizona, United States, 85023 HOPE Research Institute Phoenix, Arizona, United States, 85050 United States, California Vertex Clinical Research Bakersfield, California, United States, 93311 United States, Pennsylvania University Orthopedics Center State College, Pennsylvania, United States, 16801 United States, Texas SCIREX Corporation Austin, Texas, United States, 78705 SCIREX Corporation San Marcos, Texas, United States, 78666 United States, Utah Jean Brown Research Salt Lake City, Utah, United States, 84124 Collapse << |
NCT00474799 | Healthy | Phase 1 | Completed | - | United States, Texas ... more >> CEDRA Corporation Austin, Texas, United States, 78754 Collapse << |
NCT02696512 | Brain Injury | Phase 1 Phase 2 | Unknown | April 2017 | United States, New Jersey ... more >> International Brain Research Foundation Recruiting Edison, New Jersey, United States, 08837 Contact: Philip Defina, PhD 732-494-7600 pdefina@ibrfinc.org Principal Investigator: Philip Defina, PhD Collapse << |
NCT02534519 | - | - | Unknown | June 2018 | Switzerland ... more >> Blutpende Zürich, Dienstleistungszentrum Recruiting Schlieren, Zürich, Switzerland, 8952 Contact: Christoph Gassner, PhD +41 58 272 5195 c.gassner@zhbsd.ch Collapse << |
NCT02971371 | Stroke | Not Applicable | Completed | - | - |
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