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CAS No.: 82586-52-5

Moexipril HCl/盐酸莫西普利 Catalog No. CSN11458

Synonyms: RS-10085;Moexipril (hydrochloride);CI-925

Moexipril HCl is a potent orally active non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor, which is used for the treatment of hypertension and congestive heart failure.

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技术信息

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描述Moexipril HCl is a potent orally active non-sulfhydryl angiotensin converting enzyme(ACE) inhibitor, which is used for the treatment of hypertension and congestive heart failure^[3]. Moexipril alone and in combination with low-dose hydrochlorothiazide has been shown in clinical trials to be effective in lowering blood pressure and be well tolerated and safe given in single daily doses^[4]. Equidose treatment (10 mg/kg/day) with moexipril and enalapril over 4 weeks led to comparable decreases in blood pressure, inhibition of plasma ACE and reduction of plasma angiotensinogen and to a similar attenuation of the pressor responses to angiotensin I and potentiation of the depressor responses to bradykinin^[5]. Moexipril is effective and well tolerated in the treatment of hypertensive, postmenopausal women and can safely be co-administered to HRT (hormonal replacement therapy) ^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01867047	Adverse Effects of Angiotensin... more >>-converting-enzyme Inhibitors Hypotension Collapse <<	Not Applicable	Terminated(Following an interi... more >>m analysis the study team felt that there was enough data that showed no significant difference.) Collapse <<	-	United States, North Carolina ... more >> Duke University Durham, North Carolina, United States, 27710 Collapse <<
NCT01669434	-	-	Completed	-	-
NCT01669434	Hypotension on Induction	Phase 4	Completed	-	United States, Nebraska ... more >> University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8691 mL
- 9.3453 mL
- 18.6906 mL
- 5 mM
- 0.3738 mL
- 1.8691 mL
- 3.7381 mL
- 10 mM
- 0.1869 mL
- 0.9345 mL
- 1.8691 mL

技术信息

CAS号	82586-52-5	储存条件	粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C27H35ClN2O7	运输	蓝冰
分子量	535.03	别名	RS-10085;Moexipril (hydrochloride);CI-925;RS 10085-197;SPM-925;Moexipril. trade name Univasc

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01867047	Adverse Effects of Angiotensin... more >>-converting-enzyme Inhibitors Hypotension Collapse <<	Not Applicable	Terminated(Following an interi... more >>m analysis the study team felt that there was enough data that showed no significant difference.) Collapse <<	-	United States, North Carolina ... more >> Duke University Durham, North Carolina, United States, 27710 Collapse <<
NCT01669434	-	-	Completed	-	-
NCT01669434	Hypotension on Induction	Phase 4	Completed	-	United States, Nebraska ... more >> University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 Collapse <<
NCT01867047	-	-	Terminated(Following an interi... more >>m analysis the study team felt that there was enough data that showed no significant difference.) Collapse <<	-	-
NCT00684489	Hypertension	Not Applicable	Completed	-	-
NCT00834067	-	-	Completed	-	-
NCT00835042	Healthy	Phase 1	Completed	-	United States, Missouri ... more >> Gateway Medical Research, Inc. St. Charles, Missouri, United States, 63301 United States, Texas Bioassay Laboratory, Inc. Houston, Texas, United States, 77099 Collapse <<
NCT00835042	-	-	Completed	-	-
NCT00990301	Healthy	Phase 1	Completed	-	United States, Pennsylvania ... more >> Novum Pharmaceutical Research Services Pittsburg, Pennsylvania, United States, 15206 Collapse <<
NCT00992862	Healthy	Phase 1	Completed	-	United States, Pennsylvania ... more >> Novum Pharmaceutical Research Services Pittsburg, Pennsylvania, United States, 15206 Collapse <<
NCT00588302	Primary Biliary Cirrhosis	Phase 2	Completed	-	United States, Minnesota ... more >> Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse <<
NCT00834067	Healthy	Phase 1	Completed	-	United States, Missouri ... more >> Gateway Medical Research, Inc. St. Charles, Missouri, United States, 63301 United States, Texas Bioassay Laboratory, Inc. Houston, Texas, United States, 77099 Collapse <<
NCT01669434	-	-	Completed	-	-
NCT01867047	Adverse Effects of Angiotensin... more >>-converting-enzyme Inhibitors Hypotension Collapse <<	Not Applicable	Terminated(Following an interi... more >>m analysis the study team felt that there was enough data that showed no significant difference.) Collapse <<	-	United States, North Carolina ... more >> Duke University Durham, North Carolina, United States, 27710 Collapse <<
NCT01669434	Hypotension on Induction	Phase 4	Completed	-	United States, Nebraska ... more >> University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 Collapse <<
NCT00684489	Hypertension	Not Applicable	Completed	-	-
NCT00588302	Primary Biliary Cirrhosis	Phase 2	Completed	-	United States, Minnesota ... more >> Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse <<
NCT01867047	-	-	Terminated(Following an interi... more >>m analysis the study team felt that there was enough data that showed no significant difference.) Collapse <<	-	-
NCT00834067	Healthy	Phase 1	Completed	-	United States, Missouri ... more >> Gateway Medical Research, Inc. St. Charles, Missouri, United States, 63301 United States, Texas Bioassay Laboratory, Inc. Houston, Texas, United States, 77099 Collapse <<
NCT00990301	Healthy	Phase 1	Completed	-	United States, Pennsylvania ... more >> Novum Pharmaceutical Research Services Pittsburg, Pennsylvania, United States, 15206 Collapse <<
NCT00835042	Healthy	Phase 1	Completed	-	United States, Missouri ... more >> Gateway Medical Research, Inc. St. Charles, Missouri, United States, 63301 United States, Texas Bioassay Laboratory, Inc. Houston, Texas, United States, 77099 Collapse <<
NCT00992862	Healthy	Phase 1	Completed	-	United States, Pennsylvania ... more >> Novum Pharmaceutical Research Services Pittsburg, Pennsylvania, United States, 15206 Collapse <<
NCT00834067	-	-	Completed	-	-
NCT00835042	-	-	Completed	-	-

Moexipril HCl/盐酸莫西普利 Catalog No. CSN11458

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