|(2S,3S,4S,5R,6R)-6-(((3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-8a-羧基-4,4,6a,6b,11,11,14b-七甲基-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-基)氧基)-3,5-二羟基-4-(((2S,3R,4S,5R)-3,4,5-三羟基四氢-2H-吡喃-2-基)氧)四氢-2H-吡喃-2-羧酸|CsnPharm

CAS No.: 96990-18-0

Momordin Ic Catalog No. CSN11464

Synonyms: 地肤子皂苷Ic

Momordin Ic, a natural product isolated and purified from the fruits of Kochia scoparia (L.) Schrad., might represent a potential source of anticancer candidate, by inducing apoptosis through oxidative stress-regulated mitochondrial dysfunction involving the MAPK and PI3K-mediated iNOS and HO-1 pathways.

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技术信息

生物活性

描述Momordin Ic (MI), a natural product isolated and purified from the fruits of Kochia scoparia (L.) Schrad., might represent a potential source of anticancer candidate, by inducing apoptosis through oxidative stress-regulated mitochondrial dysfunction involving the MAPK and PI3K-mediated iNOS and HO-1 pathways. Momordin Ic promoted the formation of autophagic vacuole and expression of Beclin 1 and LC-3 in a dose- and time-dependent manner^[3]. Momordin Ic prevent cell invasion by inhibiting VCAM-1, ICAM-1, MMP-9 but inducing E-cadherin expression via p38 and JNK pathways^[4]. MI inhibited cell proliferation with G0/1 phase cell cycle arrest in colon cancer cells. MI exerted an anti-tumor activity in colon cancer cells via SENP1/c-Myc signaling pathway^[5]. MI, a new type of SENP1 inhibitor, reduces LPS-induced cellular inflammation by depressing SENP1 expression. Furthermore, MI-depressed Sp3 expression disturbed Sp3-nuclear factor (NF)-κB interaction and then alleviated LPS-induced cellular inflammation^[6]. Momordin Ic, but not 20-hydroxyecdysone and oleanolic acid, had inhibitory effects on the production of inflammatory cytokines TNF-α and IL-6 in LPS-treated RAW264.7 macrophages^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.3073 mL
- 6.5365 mL
- 13.0729 mL
- 5 mM
- 0.2615 mL
- 1.3073 mL
- 2.6146 mL
- 10 mM
- 0.1307 mL
- 0.6536 mL
- 1.3073 mL

技术信息

CAS号

96990-18-0

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C41H64O13

运输

蓝冰

分子量

764.94

别名

地肤子皂苷Ic

溶解度

DMSO	100.0 mg/mL (130.7 mM)

动物实验配方

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