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CAS No.: 151767-02-1
Synonyms: MK0476;Montelukast (sodium salt);MK-476
Montelukast Sodium is a potent, selective and competitive LTR1 antagonist with IC50 value < 5 nM, possesssing anti-inflammatory and bronchodilating activities.
生物活性
动物研究 | |||||||||||||||||||||||||||||||||
剂量 | Rat: 0.2 mg/kg - 20 mg/kg[3] (i.g.) | ||||||||||||||||||||||||||||||||
给药途径 | i.g. | ||||||||||||||||||||||||||||||||
动物药代数据 |
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT02110654 | Sinusitis Nas... more >>al Polyps Asthma Collapse << | Phase 4 | Unknown | June 2016 | China, Guangdong ... more >> the first affiliated hospital, Sun Yat-sen University Not yet recruiting Guangzhou, Guangdong, China, 510080 Contact: Fenghong Chen, doctor 02086013560170816 chfhong@mail.sysu.edu.cn Principal Investigator: jianbo Shi, doctor Collapse << |
NCT00504946 | Asthma | Phase 3 | Completed | - | Poland ... more >> Department of Pediatrics and Allergy, Medical University of Lodz Lodz, Poland Lodz, Poland, 93-513 Collapse << |
NCT00398151 | Asthma | Phase 3 | Completed | - | - |
实验方案
技术信息
CAS号 | 151767-02-1 | 储存条件 |
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分子式 | C35H35ClNNaO3S | 运输 | 蓝冰 | |||||||||
分子量 | 608.17 | 别名 | MK0476;Montelukast (sodium salt);MK-476;trade names Singulair;Montelo-10;Monteflo;Lukotas;Lumona;孟鲁司特钠 | |||||||||
溶解度 |
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动物实验配方 |
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT02110654 | Sinusitis Nas... more >>al Polyps Asthma Collapse << | Phase 4 | Unknown | June 2016 | China, Guangdong ... more >> the first affiliated hospital, Sun Yat-sen University Not yet recruiting Guangzhou, Guangdong, China, 510080 Contact: Fenghong Chen, doctor 02086013560170816 chfhong@mail.sysu.edu.cn Principal Investigator: jianbo Shi, doctor Collapse << |
NCT00504946 | Asthma | Phase 3 | Completed | - | Poland ... more >> Department of Pediatrics and Allergy, Medical University of Lodz Lodz, Poland Lodz, Poland, 93-513 Collapse << |
NCT00398151 | Asthma | Phase 3 | Completed | - | - |
NCT00394160 | Bronchiolitis | Phase 2 | Completed | - | - |
NCT02720081 | Asthma | Phase 2 | Completed | - | - |
NCT00979901 | - | - | Completed | - | - |
NCT01424124 | Asthma | Phase 2 | Completed | - | Korea, Republic of ... more >> Seoul National University Hospital Seoul, Korea, Republic of Collapse << |
NCT00756418 | Asthma | Phase 4 | Completed | - | - |
NCT02720081 | - | - | Completed | - | - |
NCT02104674 | Asthma | Phase 3 | Completed | - | - |
NCT00551382 | Upper Respiratory Tract Infect... more >>ion Collapse << | Phase 3 | Unknown | June 2010 | Israel ... more >> Kupat Cholim Clalit Recruiting Lod, Israel Contact: Al Garushi Principal Investigator: Al Garushi, MD Kupat Cholim Clalit Recruiting Ramla, Israel Principal Investigator: Zachi Lotem Assaf Harofeh Recruiting Zerifin, Israel, 70300 Contact: Berkovitch 97289779152 Principal Investigator: Mati Berkovitch, MD Collapse << |
NCT02341573 | Childhood Asthma | Not Applicable | Completed | - | China, Shanghai ... more >> Department of Chinese Traditional Medicine; Children Hospital of Fudan University Shanghai, Shanghai, China, 201102 Collapse << |
NCT00492102 | Bronchopulmonary Dysplasia | Phase 1 | Completed | - | United States, Ohio ... more >> Good Samaritan Hospital Cincinnati, Ohio, United States, 45220-2489 Collapse << |
NCT03369119 | Acute Asthma ... more >>Acute Wheezy Bronchitis Collapse << | Phase 4 | Completed | - | Turkey ... more >> Kecioren Education and Training Hospital Ankara, Keçiören, Turkey, 06380 Collapse << |
NCT00273013 | Asthma | Phase 1 | Completed | - | United Kingdom ... more >> GSK Investigational Site Manchester, Lancashire, United Kingdom, M23 9LT GSK Investigational Site London, United Kingdom, SE1 9RT Collapse << |
NCT00943683 | - | - | Completed | - | - |
NCT00912171 | Obstructive Sleep Apnea Syndro... more >>me Collapse << | Phase 4 | Completed | - | Italy ... more >> Department if Pediatrics, Hospital S. Orsola-Malpighi , University of Bologna Bologna, Italy, 40138 Collapse << |
NCT00943683 | Asthma | Not Applicable | Completed | - | - |
NCT00913328 | Asthma | Phase 4 | Completed | - | - |
NCT00968149 | Seasonal Allergic Rhinitis | Phase 3 | Completed | - | - |
NCT00968149 | - | - | Completed | - | - |
NCT00979901 | Seasonal Allergic Rhinitis | Phase 3 | Completed | - | - |
NCT00511316 | Eosinophilic Esophagitis | Phase 1 | Completed | - | United States, Minnesota ... more >> Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse << |
NCT00637611 | Seasonal Allergic Rhinitis | Phase 4 | Completed | - | United States, New Jersey ... more >> Sanofi-Aventis Bridgewater, New Jersey, United States, 08807 Collapse << |
NCT00092144 | Asthma | Phase 3 | Completed | - | - |
NCT01140048 | - | - | Completed | - | - |
NCT01140048 | - | - | Completed | - | - |
NCT01770899 | Status Asthmaticus | Not Applicable | Unknown | - | United States, Illinois ... more >> Advocate Children's Hospital Oak Lawn Recruiting Oak Lawn, Illinois, United States, 60453 Principal Investigator: Corrie Fletcher, DO Collapse << |
NCT00273689 | Exercise Induced Bronchospasm | Phase 4 | Completed | - | United States, New Mexico ... more >> University of New Mexico Albuquerque, New Mexico, United States, 87131 Collapse << |
NCT00442559 | Asthma Allerg... more >>ic Rhinitis Collapse << | Phase 4 | Completed | - | - |
NCT00442559 | - | - | Completed | - | - |
NCT00524693 | Bronchiolitis | Not Applicable | Completed | - | - |
NCT00488176 | Seasonal Allergic Rhinitis | Phase 4 | Unknown | December 2013 | Poland ... more >> Department of Pediatrics and Allergy, Medical University of Lodz Lodz, Poland Recruiting Lodz, Poland, 93-513 Contact: Violetta Ścibiorek, MD 00 48 42 689 59 72 alergol@kopernik.lodz.pl Principal Investigator: Iwona Stelmach, MD, PhD, Prof Collapse << |
NCT01943942 | Asthma | Phase 1 | Completed | - | - |
NCT01863654 | Asthma | Phase 1 | Completed | - | - |
NCT00289874 | Asthma | Phase 3 | Completed | - | - |
NCT00960141 | Seasonal Allergic Rhinitis | Phase 3 | Completed | - | - |
NCT00289874 | - | - | Completed | - | - |
NCT00968201 | Asthma | Phase 3 | Completed | - | - |
NCT00351364 | Coronary Artery Disease ... more >> Acute Coronary Syndrome Collapse << | Phase 4 | Terminated(Diffic;ulty recruit... more >>ing) Collapse << | - | Canada, Alberta ... more >> Foothills Medical Center Calgary, Alberta, Canada, T2N 2T9 Collapse << |
NCT00960141 | - | - | Completed | - | - |
NCT00968201 | - | - | Completed | - | - |
NCT00337675 | Asthma | Phase 3 | Completed | - | - |
NCT00943397 | Asthma | Phase 3 | Completed | - | - |
NCT01852812 | Perennial Allergic Rhinitis | Phase 3 | Completed | - | - |
NCT00943397 | - | - | Completed | - | - |
NCT00284856 | Asthma | Phase 3 | Completed | - | - |
NCT00337675 | - | - | Completed | - | - |
NCT00284856 | - | - | Completed | - | - |
NCT01621386 | Asthma | Phase 1 | Completed | - | United States, North Carolina ... more >> Duke University Medical Center Durham, North Carolina, United States, 27705 Collapse << |
NCT00092105 | Asthma, Bronchial ... more >> Rhinitis, Allergic, Perennial Collapse << | Phase 3 | Completed | - | - |
NCT00656058 | - | - | Completed | - | - |
NCT00656058 | Bronchiolitis Obliterans ... more >> Chronic Graft Versus Host Disease Leukotriene Montelukast Stem Cell Transplant Collapse << | Phase 2 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT00770900 | Asthma | Phase 4 | Completed | - | - |
NCT00534976 | Exercise-induced Bronchoconstr... more >>iction (EIB) Collapse << | Phase 4 | Completed | - | - |
NCT01086527 | Asthma | Phase 1 | Unknown | September 2014 | United States, Florida ... more >> Nemours Children's Clinic Recruiting Jacksonville, Florida, United States, 32207 Contact: Mary K Warde, RN 904-697-3176 mwarde@nemours.org Principal Investigator: Edward B Mougey, Ph.D. Sub-Investigator: John J Lima, PharmD Sub-Investigator: Jason E Lang, MD Collapse << |
NCT00534976 | - | - | Completed | - | - |
NCT01673620 | - | - | Completed | - | - |
NCT01673620 | Allergic Rhinitis | Phase 3 | Completed | - | - |
NCT00863317 | - | - | Completed | - | - |
NCT00394069 | Bronchiolitis | Phase 2 | Completed | - | - |
NCT01852812 | - | - | Completed | - | - |
NCT00540839 | Asthma, Bronchial | Phase 3 | Withdrawn(Based on input from ... more >>regulatory agencies, it is not necessary to conduct this study. An ongoing study was sufficient for regulatory purposes.) Collapse << | - | - |
NCT00700661 | Asthma | Phase 3 | Completed | - | - |
NCT00380705 | Asthma Rhinit... more >>is Allergic Collapse << | Phase 4 | Completed | - | - |
NCT00117338 | - | - | Completed | - | - |
NCT00445107 | Asthma | Phase 3 | Completed | - | - |
NCT00863317 | Bronchiolitis | Not Applicable | Completed | - | United States, Wisconsin ... more >> Children's Hospital of Wisconsin Milwaukee, Wisconsin, United States, 53226 Collapse << |
NCT00076973 | Bronchiolitis | Phase 3 | Completed | - | - |
NCT00664937 | Asthma, Exercise-induced | Phase 1 | Completed | - | - |
NCT02658422 | Respiratory Disorders ... more >> Asthma and Rhinitis Collapse << | Phase 1 | Completed | - | India ... more >> GSK Investigational Site Telangana, India, 500 013 Collapse << |
NCT00406094 | Rhinitis | Phase 4 | Unknown | December 2009 | United States, Ohio ... more >> Bernstein Allergy Group Recruiting Cincinnati, Ohio, United States, 45231 Contact: Jonathan A Bernstein, MD 513-931-0775 bernsteincrc@fuse.net Principal Investigator: Jonathan A Bernstein, MD Collapse << |
NCT00832455 | - | - | Completed | - | - |
NCT00117338 | Asthma | Phase 3 | Completed | - | - |
NCT01659892 | Asthma | Early Phase 1 | Completed | - | United States, North Dakota ... more >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Collapse << |
NCT01659905 | Asthma | Early Phase 1 | Completed | - | United States, North Dakota ... more >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Collapse << |
NCT00545324 | Asthma | Phase 4 | Completed | - | - |
NCT01659918 | Asthma | Early Phase 1 | Completed | - | United States, North Dakota ... more >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Collapse << |
NCT00446186 | Rhinitis Allergic | Phase 2 | Completed | - | - |
NCT00489346 | Asthma, Bronchial | Phase 3 | Completed | - | - |
NCT00638118 | Allergic Rhinitis | Phase 4 | Completed | - | United States, New Jersey ... more >> Sanofi-Aventis Bridgewater, New Jersey, United States, 08807 Collapse << |
NCT00832455 | Asthma | Phase 4 | Completed | - | - |
NCT00636207 | Asthma | Phase 1 | Completed | - | - |
NCT00739297 | Chronic Asthma | Phase 1 | Completed | - | - |
NCT01659931 | Asthma | Early Phase 1 | Completed | - | United States, North Dakota ... more >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Collapse << |
NCT01491503 | Healthy | Phase 1 | Completed | - | Korea, Republic of ... more >> Samsung medical center Seoul, Korea, Republic of Collapse << |
NCT00442338 | - | - | Completed | - | - |
NCT00636207 | - | - | Completed | - | - |
NCT01857063 | Seasonal Allergic Rhinitis | Phase 3 | Completed | - | - |
NCT00442338 | Asthma | Phase 3 | Completed | - | - |
NCT01857063 | - | - | Completed | - | - |
NCT00911547 | - | - | Completed | - | - |
NCT00739297 | - | - | Completed | - | - |
NCT00127647 | Rhinitis, Allergic, Seasonal | Phase 3 | Completed | - | - |
NCT00911547 | Asthma | Phase 3 | Completed | - | - |
NCT00641472 | Asthma | Phase 4 | Completed | - | - |
NCT01307462 | Bronchiolitis Obliterans | Phase 2 | Completed | - | United States, Arizona ... more >> Mayo Clinic - Scottsdale Scottsdale, Arizona, United States, 85054 United States, California Stanford University Stanford, California, United States, 94305 United States, Florida H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612 United States, Maryland National Cancer Institute Experimental Transplantation & Immunology Branch Bethesda, Maryland, United States, 20892 United States, Massachusetts Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Minnesota Masonic Cancer Center, University of Minnesota Minneapolis, Minnesota, United States, 55455 United States, Missouri Siteman Cancer Center at Washington University Saint Louis, Missouri, United States, 63110 United States, New York Weill Cornell Medical College New York, New York, United States, 10065 United States, Tennessee Vanderbilt University Nashville, Tennessee, United States, 37232 United States, Washington Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium Seattle, Washington, United States, 98109 United States, Wisconsin Medical College of Wisconsin Milwaukee, Wisconsin, United States, 53226 Collapse << |
NCT00092989 | Asthma | Phase 3 | Completed | - | - |
NCT00229970 | Asthma | Phase 3 | Completed | - | - |
NCT00157937 | Asthma Allerg... more >>ic Rhinitis Collapse << | Phase 4 | Completed | - | - |
NCT00140881 | Asthma | Phase 4 | Completed | - | - |
NCT00162864 | Asthma COPD | Phase 3 | Completed | - | United States, Oregon ... more >> Kaiser Permanente Center for Health Research Portland, Oregon, United States, 97227 Collapse << |
NCT01307462 | - | - | Completed | - | - |
NCT00140946 | Asthma | Phase 4 | Completed | - | - |
NCT02479854 | Healthy | Phase 1 | Completed | - | Egypt ... more >> Genuine Research Center GRC Cairo, Egypt Collapse << |
NCT01651481 | Rhinitis | Phase 1 | Completed | - | Korea, Republic of ... more >> Samsung medical center Seoul, Korea, Republic of Collapse << |
NCT01931501 | Healthy | Phase 1 | Completed | - | India ... more >> Bio Evaluation Centre, Torrent Pharmaceuticals Ltd. Village Bhat, Gandhinagar, Gujarat, India, 382428 Collapse << |
NCT01931514 | Healthy | Phase 1 | Completed | - | India ... more >> Bio Evaluation Centre, Torrent Pharmaceuticals Ltd. Village Bhat, Gandhinagar, Gujarat, India, 382428 Collapse << |
NCT01928069 | Healthy | Phase 1 | Completed | - | India ... more >> Bio Evaluation Centre, Torrent Pharmaceuticals Ltd. Village Bhat, Gandhinagar,, Gujarat,, India, 382428 Collapse << |
NCT02480049 | Healthy | Phase 1 | Completed | - | Egypt ... more >> Genuine Research Center GRC Cairo, Egypt Collapse << |
NCT01928056 | Healthy | Phase 1 | Completed | - | India ... more >> Bio Evaluation Centre, Torrent Pharmaceuticals Ltd. Village Bhat, Gandhinagar, Gujarat, India, 382428 Collapse << |
NCT01717625 | Premature Birth ... more >> Infant, Very Low Birth Weight Bronchopulmonary Dysplasia Collapse << | Phase 2 | Completed | - | Korea, Republic of ... more >> Ajou university medical center Suwon, Woncheon-dong, Yeongtong-gu,, Korea, Republic of, 443-721 Collapse << |
NCT00229970 | - | - | Completed | - | - |
NCT01640535 | Perennial Allergic Rhinitis | Phase 3 | Completed | - | Korea, Republic of ... more >> Soonchunhyang University Bucheon Hospital Bucheon, Gyeonggi-do, Korea, Republic of, 420-767 Collapse << |
NCT00771160 | Rhinitis, Allergic | Phase 3 | Completed | - | - |
NCT00545844 | - | - | Completed | - | - |
NCT02029313 | Asthma and Allergic Rhinitis | Phase 1 | Completed | - | Korea, Republic of ... more >> Inha University Hospital Incheon, Junggu, Korea, Republic of Collapse << |
NCT00755794 | Asthma | Phase 3 | Completed | - | - |
NCT00545844 | Asthma | Phase 4 | Completed | - | - |
NCT02322671 | Respiratory Disorders | Phase 1 | Completed | - | India ... more >> GSK Investigational Site Hyderabad, India, 500 013 Collapse << |
NCT01691456 | Healthy | Phase 1 | Completed | - | India ... more >> AXIS Clinicals Limited, Hyderabad, Andhra Pradesh, India, 500 049 Collapse << |
NCT01674504 | Healthy | Phase 1 | Completed | - | India ... more >> Bioserve Clinical Research Private Limited Balanagar, Hyderabad, India, 500 037 Collapse << |
NCT01671709 | Healthy | Phase 1 | Completed | - | India ... more >> Bioserve Clinical Research Private Limited Balanagar, Hyderabad, India, 500 037 Collapse << |
NCT01691469 | Healthy | Phase 1 | Completed | - | India ... more >> AXIS Clinicals Limited, Hyderabad, Andhra Pradesh, India, 500 049 Collapse << |
NCT02494466 | Airway Reactivity | Phase 4 | Completed | - | Turkey ... more >> Gulsah Karaoren Istanbul, Turkey Collapse << |
NCT01671722 | Healthy | Phase 1 | Completed | - | India ... more >> Bioserve Clinical Research Private Limited Balanagar, Hyderabad, India, 500 037 Collapse << |
NCT01674517 | Healthy | Phase 1 | Completed | - | India ... more >> Bioserve Clinical Research Private Limited Balanagar, Hyderabad, India, 500 037 Collapse << |
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