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CAS No.: 857876-30-3
Synonyms: AMG 706 Diphosphate;AMG-706;Motesanib
Motesanib diphosphate is ATP-competitive inhibitor of VEGFR1, VEGFR2 and VEGFR3 with IC50 of 2 nM, 3 nM and 6 nM, respectively. It also shows better inhibitory activity against c-Kit, PDGFR, and RET.
生物活性
靶点 | VEGFR1 IC50:2nM | VEGFR2 IC50:3nM | VEGFR3 IC50:6nM |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT01700699 | - | - | Unknown | October 2013 | Italy ... more >> Department of Medicine and Surgery, Univeristy of Salerno Recruiting Baronissi, Salerno, Italy, 84081 Contact: Mario Vitale, MD +39 089672539 mavitale@unisa.it Principal Investigator: Mario Vitale, MD Collapse << |
NCT01265927 | Breast Neoplasms | Phase 1 | Completed | - | United States, Indiana ... more >> Indiana University Simon Cancer Center Indianapolis, Indiana, United States, 46202 Collapse << |
NCT00861419 | Advanced Solid Tumors | Phase 1 | Completed | - | - |
实验方案
技术信息
CAS号 | 857876-30-3 | 储存条件 |
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分子式 | C22H29N5O9P2 | 运输 | 蓝冰 | |||||||||
分子量 | 569.44 | 别名 | AMG 706 Diphosphate;AMG-706;Motesanib;motesanib phosphate;motesanib diphosphate | |||||||||
溶解度 |
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动物实验配方 |
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT01700699 | - | - | Unknown | October 2013 | Italy ... more >> Department of Medicine and Surgery, Univeristy of Salerno Recruiting Baronissi, Salerno, Italy, 84081 Contact: Mario Vitale, MD +39 089672539 mavitale@unisa.it Principal Investigator: Mario Vitale, MD Collapse << |
NCT01265927 | Breast Neoplasms | Phase 1 | Completed | - | United States, Indiana ... more >> Indiana University Simon Cancer Center Indianapolis, Indiana, United States, 46202 Collapse << |
NCT00861419 | Advanced Solid Tumors | Phase 1 | Completed | - | - |
NCT02084732 | Thyroid Cancer | Phase 2 | Unknown | June 2018 | Colombia ... more >> Instituto Nacional de Cancerología Recruiting Bogotá, Cundinamarca, Colombia, 00000 Contact: Yeinnyer C. Muleth, BSc 3340106 ymuleth@cancer.gov.co Principal Investigator: Luis F Fierro, Md Sub-Investigator: Gloria Garavito, Md Sub-Investigator: Andres A Cuellar, Md Sub-Investigator: Jose A. Carreño, Md Sub-Investigator: Juan S Castillo, Md Collapse << |
NCT00310895 | Solid Tumor Malignancies | Phase 1 | Completed | - | United States, Illinois ... more >> The University of Chicago Medical Center Chicago, Illinois, United States, 60637 United States, Michigan Wayne State University, Karmanos Cancer Center Detroit, Michigan, United States, 48201 Collapse << |
NCT00324597 | Lung Cancer L... more >>ymphoma Lymphoproliferative Disorder Unspecified Adult Solid Tumor, Protocol Specific Collapse << | Phase 1 | Unknown | - | United States, California ... more >> Jonsson Comprehensive Cancer Center at UCLA Los Angeles, California, United States, 90095-1781 Collapse << |
NCT00594126 | Multiple Myeloma | Phase 1 | Completed | - | United States, Maryland ... more >> Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University Baltimore, Maryland, United States, 21231 United States, Massachusetts Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, New York Roswell Park Cancer Institute Buffalo, New York, United States, 14263 Collapse << |
NCT00718601 | Multiple Myeloma | Phase 1 | Completed | - | United States, Michigan ... more >> Karmanos Cancer Center Detroit, Michigan, United States, 48201 United States, New York St. Vincent's Comprehensive Cancer Center New York City, New York, United States, 10011 United States, Washington Fred Hutchinson Cancer Research Center Seattle, Washington, United States, 98109 Collapse << |
NCT00356681 | Breast Neoplasms ... more >> Breast Tumors Breast Cancer Locally Recurrent and Metastatic Breast Cancer Collapse << | Phase 2 | Terminated(Sponsor decision to... more >> close study) Collapse << | - | - |
NCT00427349 | Gastrointestinal Carcinoid Tum... more >>or Islet Cell Tumor Neoplastic Syndrome Collapse << | Phase 2 | Completed | - | - |
NCT00369070 | Advanced Non-squamous NSCLC | Phase 2 | Terminated | - | - |
NCT00427349 | - | - | Completed | - | - |
NCT00510445 | Lung Cancer | Phase 1 | Completed | - | United States, Maryland ... more >> University of Maryland Greenebaum Cancer Center Baltimore, Maryland, United States, 21201 United States, Texas The University of Texas Southwestern Medical Center Dallas, Texas, United States, 75390 UT MD Anderson Cancer Center Houston, Texas, United States, 77030 United States, Wisconsin University of Wisconsin, Paul P. Carbone Comprehensive Cancer Center Madison, Wisconsin, United States, 53792 Collapse << |
NCT00360867 | Solid Tumors | Phase 2 | Terminated(Amgen decision) | - | - |
NCT00574951 | - | - | Terminated(Study was stopped f... more >>or severe toxicity causing concern for patients) Collapse << | - | - |
NCT00460317 | Non-Small Cell Lung Cancer | Phase 3 | Terminated(Amgen discontinued ... more >>the development of AMG706 because 20050201 did not meet its primary objective.) Collapse << | - | - |
NCT00574951 | Fallopian Tube Cancer ... more >> Ovarian Cancer Primary Peritoneal Cavity Cancer Collapse << | Phase 2 | Terminated(Study was stopped f... more >>or severe toxicity causing concern for patients) Collapse << | - | United States, California ... more >> Providence Saint Joseph Medical Center - Burbank Burbank, California, United States, 91505 United States, Connecticut George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus New Britain, Connecticut, United States, 06050 United States, Illinois University of Illinois Cancer Center Chicago, Illinois, United States, 60612-7243 Rush University Medical Center Chicago, Illinois, United States, 60612 Hinsdale Hematology Oncology Associates Hinsdale, Illinois, United States, 60521 United States, Indiana St. Vincent Indianapolis Hospital Indianapolis, Indiana, United States, 46260 United States, Missouri St. John's Regional Health Center Springfield, Missouri, United States, 65804 Hulston Cancer Center at Cox Medical Center South Springfield, Missouri, United States, 65807 United States, New Jersey Cancer Institute of New Jersey at Cooper - Voorhees Voorhees, New Jersey, United States, 08043 United States, North Carolina Blumenthal Cancer Center at Carolinas Medical Center Charlotte, North Carolina, United States, 28232-2861 United States, Ohio Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44106-5065 Mount Carmel Health - West Hospital Columbus, Ohio, United States, 43222 Lake/University Ireland Cancer Center Mentor, Ohio, United States, 44060 United States, Oklahoma Oklahoma University Cancer Institute Oklahoma City, Oklahoma, United States, 73104 United States, Pennsylvania Rosenfeld Cancer Center at Abington Memorial Hospital Abington, Pennsylvania, United States, 19001 Fox Chase Cancer Center - Philadelphia Philadelphia, Pennsylvania, United States, 19111-2497 McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center Reading, Pennsylvania, United States, 19612-6052 United States, Texas Harrington Cancer Center Amarillo, Texas, United States, 79106 United States, Virginia University of Virginia Cancer Center Charlottesville, Virginia, United States, 22908 Collapse << |
NCT00094835 | Lung Cancer N... more >>on-Small Cell Lung Cancer Collapse << | Phase 1 Phase 2 | Completed | - | - |
NCT01386866 | Advanced Solid Tumors | Phase 1 | Completed | - | - |
NCT01256762 | Locally Recurrent or Metastati... more >>c Breast Cancer Collapse << | Phase 2 | Completed | - | - |
NCT01568632 | Solid Tumors ... more >>Lymphoma Collapse << | Phase 1 | Withdrawn | - | - |
NCT00094835 | - | - | Completed | - | - |
NCT01349088 | Breast Cancer ... more >> Metastatic Breast Cancer Stage IV Breast Cancer Collapse << | Phase 1 Phase 2 | Withdrawn | September 2018 | United States, Pennsylvania ... more >> Thomas Jefferson University Philadelphia, Pennsylvania, United States, 19107 Collapse << |
NCT01273090 | Brain and Central Nervous Syst... more >>em Tumors Lymphoma Lymphoproliferative Disorder Small Intestine Cancer Unspecified Childhood Solid Tumor, Protocol Specific Collapse << | Phase 1 | Completed | - | - |
NCT01137968 | Non-small Cell Lung Cancer | Phase 2 | Completed | - | - |
NCT01731951 | Primary Myelofibrosis ... more >> Secondary Myelofibrosis Myeloid Malignancies Collapse << | Phase 2 | Completed | - | United States, Minnesota ... more >> Rochester, Minnesota, United States Collapse << |
NCT01242930 | Multiple Myeloma | Phase 2 | Completed | - | United States, Maryland ... more >> University of Maryland Medical Center - M & S Greenebaum Cancer Center Baltimore, Maryland, United States, 21201 Sidney Kimmel Cancer Center Johns Hopkins Hospital Baltimore, Maryland, United States, 21231 Collapse << |
NCT02598661 | Myelodysplastic Syndromes | Phase 3 | Recruiting | February 28, 2022 | - |
NCT02629848 | Carcinoma, Non-Small-Cell Lung | Phase 3 | Terminated(Sponsor decision to... more >> terminate the study because the study did not meet the primary endpoint.) Collapse << | - | - |
NCT02426086 | Primary Myelofibrosis | Phase 2 | Active, not recruiting | April 26, 2019 | - |
NCT01836549 | Anaplastic Astrocytoma ... more >> Anaplastic Ependymoma Astrocytoma, Grade II Ependymoma Giant Cell Glioblastoma Glioblastoma Gliosarcoma Oligodendroglioma Brainstem Tumors Collapse << | Phase 2 | Terminated(Due to several intr... more >>acranial hemorrhages and recommendation by the PBTC DSMB.) Collapse << | - | United States, California ... more >> Childrens Hospital Los Angeles Los Angeles, California, United States, 90027-0700 Lucile Packard Children's Hospital at Stanford University Medical Center Palo Alto, California, United States, 94304 United States, District of Columbia Children's National Medical Center Washington, District of Columbia, United States, 20010-2970 United States, Illinois Lurie Children's Hospital- Chicago Chicago, Illinois, United States, 60614 United States, Maryland NCI - Pediatric Oncology Branch Bethesda, Maryland, United States, 20892 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, North Carolina Duke Comprehensive Cancer Center Durham, North Carolina, United States, 27710 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229-3039 United States, Pennsylvania Children's Hospital of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 United States, Tennessee Saint Jude Children's Research Hospital Memphis, Tennessee, United States, 38105-2794 United States, Texas Texas Children's Cancer Center and Hematology Service at Texas Children's Hospital Houston, Texas, United States, 77030-2399 Collapse << |
NCT01916187 | Neuroblastoma | Phase 1 | Withdrawn(drug company withdrw... more >>w support following a re-examination of the benefit-risk assessment for the investigational use of imetelstat in this population) Collapse << | - | Canada, Quebec ... more >> CHU Sainte-Justine Montreal, Quebec, Canada, H3T 1C5 Collapse << |
NCT01836549 | - | - | Terminated(Due to several intr... more >>acranial hemorrhages and recommendation by the PBTC DSMB.) Collapse << | - | - |
NCT01243073 | Essential Thrombocythemia ... more >> Polycythemia Vera Collapse << | Phase 2 | Completed | - | United States, California ... more >> City of Hope Duarte, California, United States, 91010 United States, Florida MDACC - Orlando Orlando, Florida, United States, 32806 United States, Illinois University of Chicago Chicago, Illinois, United States, 60637 United States, Maryland Johns Hopkins University - Bunting Blaustein Cancer Research Building Baltimore, Maryland, United States, 21205 United States, South Carolina Saint Francis Hospital Greenville, South Carolina, United States, 29601 United States, Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Germany University Hospital of Essen - West German Cancer Center Essen, Germany Medizinische Klinik II, Abt. Hämatologie und Onkologie - Johann Wolfgang Goethe Universität Frankfurt, Germany, D-60590 SLK-Kliniken GmbH Heilbronn, Germany Hematology Oncology Center - Ludwig-Maximilians, University Munich Medical School Munich, Germany, 80331 University Hospital Regensburg - Uniklinik Regensburg Regensburg, Germany Switzerland INSELSPITAL, University Hospital Bern Bern, Switzerland, CH - 3010 Collapse << |
NCT02011126 | Hepatoblastoma ... more >> Previously Treated Childhood Rhabdomyosarcoma Recurrent Childhood Liver Cancer Recurrent Childhood Rhabdomyosarcoma Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Recurrent Neuroblastoma Recurrent Osteosarcoma Rhabdomyosarcoma Collapse << | Phase 2 | Withdrawn(IND no longer availa... more >>ble.) Collapse << | - | - |
靶点 | Description | IC50 |
---|---|---|
VEGFR1 | IC50:2nM | |
VEGFR2 | IC50:3nM | |
VEGFR3 | IC50:6nM |
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