|N,N-二甲基二胍|CsnPharm

CAS No.: 657-24-9

二甲双胍 Catalog No. CSN24043

Synonyms: 1,1-Dimethylbiguanide;Diabetosan;Diabex

Metformin is a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis).

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400-920-2911

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描述Metformin inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin can cross the blood-brain barrier and triggers autophagy^[2]. A short-term administration of metformin strongly protected the myocardium against isoproterenol-induced infarction^[3]. Metformin decreased glycogen synthesis in a dose-dependent manner with an IC50 value of 196.5 mM. Moreover, a strong inhibition (62%) of glucose produced from lactate/pyruvate (3 mm/0.3 mm) was observed in cells treated with 350 mM metformin^[4]. A potential anti-tumourigenic effect of metformin may be mediated by its role in activating AMPK, which in turn inhibits mammalian target of rapamycin (mTOR) ^[5]. Metformin inhibits cell growth via AMPK activation and subsequent inhibition of PI3K/AKT signaling in A-ESCs (adenomyotic endometrial stroma cells), particularly during the secretory phase, suggesting a greater effect of metformin on A-ESCs from secretory phase^[6].
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实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 7.7421 mL
- 38.7106 mL
- 77.4212 mL
- 5 mM
- 1.5484 mL
- 7.7421 mL
- 15.4842 mL
- 10 mM
- 0.7742 mL
- 3.8711 mL
- 7.7421 mL

技术信息

CAS号	657-24-9	储存条件	粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C4H11N5	运输	蓝冰
分子量	129.16	别名	1,1-Dimethylbiguanide;Diabetosan;Diabex;Dimethylbiguanide;DMGG;Fluamine;Flumamine;LA-6023;Metiguanide;二甲双胍;甲福明

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