|N-{2-[2,3-双-(甲氧羰基)-胍基]-5-(苯基硫基)-苯基}-2-甲氧基乙酰胺|CsnPharm

CAS No.: 58306-30-2

非班太尔 Catalog No. CSN12807

Synonyms: 苯硫胍

Febantel can be metabolized to fenbendazole and oxfendazole, which are parasiticides.

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技术信息

生物活性

描述Febantel is widely used anthelmintic drug active against a range of gastrointestinal parasites in animals^[3]. The febantel tablet decreased the hookworm egg count by 99.9% and the whipworm egg count by 100%. The controlled test efficacies of febantel tablets against Ancylostoma caninum, Ancylostoma braziliense, and Trichuris vulpis were, 98.2%, 100% and 99.7%, respectively^[4]. Febantel was rapidly cleared from the circulation and highly metabolized. The efficacy against Ascaridia was 100% for the faecal egg count reduction (FECR) as well as for the worm reduction in all treated pigeons. After two treatments with febantel against Capillaria in heavily infected pigeons the FECR amounted to 96.7% and worm reduction was 95%. In order to effectively remove both parasites from the host, repeated treatments with febantel at a short interval could be the treatment of choice^[5]. Febantel alone, effectively eliminated Giardia trophozoites at 160 and 80 mg/kg mongolian gerbils. Febantel combined with pyrantel embonate effectively eliminated Giardia trophozoites at 160, 80 and 40 mg/kg. However, febantel is more effective in elimination of Giardia infections when combined with pyrantel embonate compared to the agents used alone^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2397 mL
- 11.1987 mL
- 22.3974 mL
- 5 mM
- 0.4479 mL
- 2.2397 mL
- 4.4795 mL
- 10 mM
- 0.2240 mL
- 1.1199 mL
- 2.2397 mL

技术信息

CAS号

58306-30-2

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H22N4O6S

运输

蓝冰

分子量

446.48

别名

苯硫胍

溶解度

DMSO	89.0 mg/mL (199.3 mM)

动物实验配方

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