|N-((4-乙酰氨基苯基)硫代氨基甲酰基)-4-(叔丁基)苯甲酰胺|CsnPharm

CAS No.: 380315-80-0

N-((4-Acetamidophenyl)carbamothioyl)-4-(tert-butyl)benzamide Catalog No. CSN15970

Synonyms: Tenovin 1

Tenovin-1 is an inhibitor of SIRT1 and SIRT2 and an activator of p21 and p53. It protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.

规格	价格	促销价格	库存	数量

400-920-2911

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技术信息

生物活性

描述Tenovin-1 is an inhibitor of SIRT1 and SIRT2 and an activator of p21 and p53. It protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
MCF7 cells	10 μM	Function assay	6 h	Inhibition of SirT1 assessed as increase in p53 expression in human MCF7 cells at 10 uM after 6 hrs by Western blotting	22304848

参考文献

[1] Nihal M, Ahmad N, Wood GS. SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis. Cell Cycle. 2014;13(4):632-40.
[2] Lain S, Hollick JJ, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7065 mL
- 13.5325 mL
- 27.0650 mL
- 5 mM
- 0.5413 mL
- 2.7065 mL
- 5.4130 mL
- 10 mM
- 0.2707 mL
- 1.3533 mL
- 2.7065 mL

技术信息

CAS号

380315-80-0

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H23N3O2S

运输

蓝冰

分子量

369.48

别名

Tenovin 1

溶解度

DMSO	74.0 mg/mL (200.3 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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N-((4-Acetamidophenyl)carbamothioyl)-4-(tert-butyl)benzamide Catalog No. CSN15970

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